Release of gonadotrophin in ovariectomized mice after exposure to males.
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Biomedical subjects
Publications and source records attributed to F H Bronson.
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Incidence of spontaneous aggression in adult male mice given a single injection of estradiol benzoate (0.4 milligram) when they were 3 days old was less than that of controls injected with oil. Aggressiveness was increased among adult females injected with either estradiol or testosterone propionate (1 milligram) at the same age. The increased aggressiveness noted among females given androgen was further documented during subsequent mating tests, when these females often attacked, wounded, and, in one case, killed naive males.
The proportion of female SJL/J mice exhibiting estrus whet 2 meters downwind (6 meters per minute) from a group of 15 hybrid mi not significantly less than that of females placed directly under the males posed to their urine. The proportion of mice showing estrus when placed 2 upwind was significantly less than that of mice downwind or of mice beloii but not different from that of females remote from males. These findings sh the pheromone from male mice is volatile and further support the concep, acts through olfactory receptors.
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Adrenalectomy in prairie deer mice is followed by a profound darkening of the fur which occurs with in 1 to 3 months. The phenomenon is most noticeable on the normally unpigmented ventral surfaces which turn dark gray or black. A possible mechanism for such hyperpigmentation would involve increased release of inelanocyte-stimulating hormones.
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Seasonal breeding is common in mammals, particularly in habitats outside the tropics. Climate and availability of food are the ultimate factors that usually dictate the optimal time of year for a mammal to breed; however, day length (photoperiod) often serves as the proximal cue to signal the onset or cessation of seasonal reproduction. Some individuals in some populations of deer mice are reproductively responsive to photoperiod, while other individuals in the same population are not. As shown here, selection can dramatically alter the frequency of photoresponsiveness in a laboratory population in only two generations. To our knowledge this is the first demonstration of selection for reproductive photoresponsiveness in any mammal. By implication, some wild populations of deer mice must use multiple, genetic-based reproductive strategies, and the degree to which each such strategy is exhibited must be subject to rapid change in response to both seasonally and momentarily changing climatic and dietary conditions.