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Biomedical subjects

F Guyon

Publications and source records attributed to F Guyon.

63 records · Page 4Linked to original sources
PubMed1985

[Assay of acenocoumarol (Sintrom) in the plasma by liquid chromatography].

Reversed-phase liquid chromatography was performed on C18 column using a pH 4 buffered water-methanol 45:55 (v/v) mobile phase and ultraviolet detection (307 nm). Warfarin was used as internal standard and dichloro-1,2 ethane as extraction solvent. The analytical recovery was greater than 98 p. cent. The within-day coefficient of variation (CV) was 5 p. cent, while the between day CV was 6.4 p. cent. The limit of detection was 0.02 mg/l.

Acenocoumarol↗
PubMed1983

[Determination of thiocyanate ions in saliva by coupling high performance liquid chromatography with specific electrode].

An electrochemical method for determination of thiocyanide ions in saliva was established. The procedure involves coupling high performance liquid chromatography (HPLC) on bounded silica gel (in order to eliminate the interference of some ions) with specific electrode. This method is sensitive, precise, rapid and requires only few samples. It offers a great interest in toxicology for the detection of smoking exposure.

Chromatography, High Pressure Liquid↗
PubMedDate not supplied

Pregnancy outcome and prognosis in fetuses with increased first-trimester nuchal translucency.

OBJECTIVE: One of the concerns of prenatal diagnosis is to find sensitive markers to screen for chromosome abnormalities, such as serum assays or nuchal translucency (NT). This study reports our experience with NT measurement during the first trimester of pregnancy. MATERIALS: The study was performed prospectively on 252 fetuses with either NT > or =3 mm or cystic hygroma. RESULTS: We observed 50 abnormal karyotypes, i.e. 19.8%. The incidence of chromosome abnormalities increased with increasing maternal age and increasing NT thickness. For the 202 fetuses with normal karyotypes, outcome was unfavourable in 32 cases: 23 elective terminations of pregnancy, 8 spontaneous abortions and 1 neonatal death. Outcome was favourable in 141 cases. Twenty-nine pregnancies were lost to follow-up. CONCLUSION: Measurement of NT at 12 weeks' gestation seems to be a good marker for chromosome abnormalities. When the karyotype is normal, the pregnancy outcome remains correlated with the degree of NT thickness. The finding of NT >3 mm between 10 and 14 weeks' gestation dictates rigorous ultrasound monitoring and caution when predicting pregnancy outcome.

Adult↗