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Biomedical subjects

F Gullotta

Publications and source records attributed to F Gullotta.

At least 217 records · Page 12Linked to original sources
PubMedDate not supplied

Mononuclear infiltrates in human intracranial tumors as a prognostic factor. Influence of preoperative steroid treatment. I. Glioblastoma.

One hundred ninety-nine glioblastomas were investigated for the presence of mononuclear infiltrates in the light of preoperative steroid treatment and in regard to their prognostic influence. Preoperative steroid treatment does not seem to severely influence the frequency of lymphocytic infiltration in the doses routinely administered by us. The presence of infiltrates corresponds with a better prognosis for the disease, and with a mean postoperative survival time of 8.1 months as compared to 5.6 months in the group without infiltrates, irrespective of adjuvant treatment. As a prognostic factor, infiltrates may be of relevance for a statistical evaluation, but not a reliable indicator in the individual case.

Brain Neoplasms↗
PubMedDate not supplied

Morphologic and pathogenetic considerations of supratentorial gliomas in children.

The results of a histological investigation carried out on 758 children's brain tumours are presented. Attention is drawn to supratentorial tumours, particularly gliomas of cerebral hemispheres (neoencephalic structures). Mono- or bicellular gliomas corresponding to tumours of adult age (astrocytoma, oligodendroglioma) as well as typical glioblastomas are seldom encountered in children. Supratentorial hemispheric tumours are mostly composed of more than two cell populations ("mixed heterogenous tumours"); this is commonly the case in infants. The importance of an extensive histological examination of many different tumour parts is stressed. Otherwise, the regional differences of neoplastic cells populations can give rise to wrong diagnoses as well as speculative hypotheses concerning "cell differentiation" or maturation" in recurrences.

Adolescent↗
PubMedDate not supplied

Desmoplastic non-infantile ganglioglioma.

A case of temporal desmoplatic ganglioglioma surgically removed in a 17-year-old patient is reported. Immunohistochemistry showed glial and neuronal differentiation of tumour cells. The frequent occurrence of a desmoplastic component in gangliogliomas is stressed. The present case and other reports from the literature confirm that such desmoplastic neoplasms can not be regarded as exclusively infantile tumours, as recently proposed by the WHO-classification of Brain Tumours.

Adolescent↗
PubMedDate not supplied

Factor XIIIa-immunoreactivity in tumors of the central nervous system.

The clotting factor XIIIa (FXIIIa) has been shown to be present both in tumor cells and in tumor-associated macrophages of different neoplasms such as Hodgkin's disease, giant cell tumor of bone, malignant fibrous histiocytoma, meningeal tumors, and hemangiopericytoma. The biological significance of these findings, however, are still unclear. This study investigates the immunohistochemical distribution of FXIIIa in 186 tumors of the central nervous system (CNS) in order to evaluate its possible diagnostic or prognostic significance in neuro-oncology. High-grade gliomas such as glioblastoma, gliosarcoma, astrocytoma (grade III WHO), and ependymoma (III) as well as meningiomas and meningeal hemangiopericytomas consistently contained factor XIIIa-positive cells, whereas low-grade glial tumors did not do so. One desmoplastic medulloblastoma and one anaplastic schwannoma also showed FXIIIa-positive cells. With the exception of hemangiopericytomas, however, the major source of FXIIIa expression in all these tumors consisted of a subpopulation of tumor-associated macrophages, the exact role of which still remains unclear. Because of its non-discriminatory staining in a wide variety of CNS tumors, the differential diagnostic contribution of FXIIIa in neuro-oncology seems to be limited.

Central Nervous System Neoplasms↗