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Biomedical subjects

F Gschnait

Publications and source records attributed to F Gschnait.

At least 73 records · Page 4Linked to original sources
PubMed1985

Photoprotective effect of topical indomethacin--an experimental study.

Indomethacin applied after an erythematogenic dose of UVB light suppresses the development of erythema by inhibition of prostaglandin synthesis. In this study indomethacin was tested prior to UV exposure in humans in vivo and was shown to be a potent UVB and UVA filter. Indomethacin thus represents the first topical agent known to prevent and treat sunburn simultaneously. A 2.5% indomethacin solution was applied on test areas 1 h before UVB irradiation. Indomethacin-pretreated skin tolerated 4.3 times more UVB light and indomethacin-protected skin developed significantly less sunburn cells than untreated areas. In order to study its possible UVA screening capacity test areas were irradiated with 2, 4, 6, 8, 10 J/cm2 UVA light (PUVA) after ingestion of 8-methoxypsoralen. Indomethacin-pretreated skin tolerated 2.2 times more UVA than untreated test areas. Immediate pigment darkening induced by UVA doses up to 25 J/cm2 was less pronounced in indomethacin-pretreated skin. To investigate the mode of action of the photoprotective effect observed skin was irradiated with erythematous doses of UVB light transmitted through a quartz glass layer coated with the indomethacin solution. The skin developed no erythema thus indicating that the effect of indomethacin when applied before irradiation is based upon photoabsorption and not upon inhibition of prostaglandin synthesis. This is also confirmed by the fact that the development of sunburn cells can be prevented only when indomethacin is applied before and not after irradiation.

Humans↗
PubMed1985

[Leg ulcers in congenital dyserythropoietic anemia].

We report on an 18-year-old male patient suffering from leg ulcers due to congenital dyserythropoetic anemia and thrombocytosis. Based on this case, we discuss the importance of hematologic disorders for the development of leg ulcers as well as the pathogenetic mechanisms involved.

Adolescent↗
PubMed1985

[Hyperkeratosis lenticularis perstans (Flegel's disease)].

Hyperkeratosis lenticularis perstans (Flegel's disease) is a rare form of dermatosis, which can only be diagnosed microscopically. A typical case is reported; histological differential diagnosis and treatment with systemic retinoids are discussed.

Aged↗
PubMed1985

Anthralin minute entire skin treatment. A new outpatient therapy for psoriasis.

Anthralin minute entire skin treatment (AMEST) was developed to improve the efficacy and cosmetic results of anthralin short-contact therapy. In a split comparison study to determine the optimal period of anthralin application, ten minutes of anthralin contact time gave maximum antipsoriatic activity with minimal side effects. Dosimetry variables for AMEST were determined based on the patient's pigmentation type, the erythematous response, the therapeutic effect, and so on. Such treatment of 43 patients resulted in complete clearing in 31 patients (72%), with 90% improvement in two patients (5%) and less than 90% clearing in seven patients (16%). Psoriatic lesions disappeared, leaving no spotty pigmentation that is known to occur following conventional anthralin therapy. The dosimetry variables employed in our study allowed AMEST with minimal skin irritation. Laboratory values did not change significantly during therapy. In addition, AMEST does not involve systemic medication and is easy to perform without special equipment; therefore, it is economic and can be used for outpatients and probably for home treatment.

Aged↗
PubMed1984

[Urticarial vasculitis].

Knowledge of urticarial vasculitis is very important, because its therapy and prognosis are different to other clinically similar diseases, eg idiopathic urticaria. We present a 72-year-old female patient suffering from recurrent urticaria associated with slight fever, arthralgia, occasional abdominal pain, as well as highly elevated erythrocyte sedimentation rate. Histologic examination of involved skin revealed leucocytoclastic vasculitis. Corticosteroid treatment led to clinical improvement. Courses of urticarial vasculitis may vary to a high degree; the clinical spectrum of urticarial vasculitis may turn to ranges from chronic idiopathic urticaria to systemic lupus erythematosus. Clinical hallmarks of urticarial vasculitis are slowly (within 72 hours) regressing wheals, arthralgia, as well as highly elevated erythrocyte sedimentation rate.

Aged↗
PubMed1984

[ANA-negative, anti-Ro-antibody positive subacute cutaneous lupus erythematosus].

A female patient presented with the typical clinical and histological features of disseminated lupus erythematosus (LE). Direct immunofluorescence, as well as antinuclear antibodies were negative, but antibodies directed against the cytoplasmic Ro-antigen were found. The Ro-antigen is regarded as highly specific for SLE and Sjögren's syndrome. Clinical features and diagnosis of this distinct LE subset ("ANA negative, anti-Ro-positive LE"), as well as the sensitivity and specificity of the substrate in ANA determinations are discussed.

Adult↗
PubMed1984

[Akrokeratoderma hereditarium punctatum].

Akrokeratoderma hereditarium punctatum is characterized by multiple, skin coloured papules on the dorsum of the hands, which develop as verrucous lesions after puberty and spread slowly in the following years. There is no subjective discomfort. Focal hyperkeratosis and hypergranulosis are histological markers; the elastic fibers appear normal. The differential diagnosis of similar keratosis of the palms and soles is discussed.

Female↗
PubMed1984

Disseminated superficial "actinic" porokeratosis.

The dramatic therapeutic response of disseminated superficial actinic porokeratosis (DSAP) to retinoid plus psoralens with ultraviolet A prompted a review of clinical, histologic, and etiologic data of all of the DSAP cases available in the English and German literature. The review showed that many case reports lack adequate documentation to confirm actinic induction. More than one third of the patients have observed no exacerbations during the summer. Histologic damage after long-term ultraviolet (UV) exposure could not be observed in every case. In addition, cases do exist in which lesions are distributed mainly in non-UV-exposed skin. These data cause doubt about the importance of actinic induction of DSAP.

Adult↗
PubMed1983

[Recent progress in syphilis serology].

Serological investigations for the diagnosis of syphilis have been performed in a special subunit at the Department of Dermatology to Lainz Hospital, Vienna, since 70 years. At present 80,000 to 100,000 sera are tested annually. The classical test systems VDRL, TPHA, AMHA-TP and FTA-ABS demonstrate, in particular, the presence of IgG antibodies and are, thus, suitable for the diagnosis of the disease, but do not permit conclusions on the activity of the disease and the actual need for antisyphilitic treatment. The newly developed IgM diagnosis of syphilis with the IgM-SPHA- and the 19S-IgM-FTA-ABS test solve these problems and can be performed even under routine conditions using the methods of solid phase haemadsorption and computerized high pressure liquid chromatography. In addition, the serological diagnosis of neurosyphilis has been worked out by the determination of the TPHA-index and the detection of antitreponemal IgM-antibodies in the cerebrospinal fluid. The relative frequency of latent syphilis infections has increased over the past years and serodiagnosis of syphilis, thus, become more and more important. The availability of five independent test systems has enabled the elaboration of a test profile which keeps the margin of error to below 0.1%. A further method, the ELISA technique is at present under investigation and renders promising results by the use of recently developed reagents.

Cerebrospinal Fluid↗
PubMed1983

[Skin metastases of malignancies of internal organs].

In 4 cases with cutaneous metastases from internal cancer the primary tumours were found in the gallbladder, the breast, the lung and the kidney. The cutaneous metastases were the first symptom of the disease in 2 of 4 cases and led to the diagnosis. Course, treatment and prognosis of secondary skin tumours are discussed in detail.

Adenocarcinoma↗
PubMed1983

[Psychogenic purpura].

A 27 year old women revealed chronic relapsing, spontaneously developing hematomas without coagulopathy. The lesions were reproducible by intradermal injection of erythrocyte membranes as well as DNA. Positive test reactions could be elicited or suppressed by psychological influences on the patient. This case and similar reports in the literature raise the question whether Gardner-Diamond syndrome and the autosensitization to DNA are different entities.

Adult↗
PubMed1983

Treatment of polymorphous light eruption.

This study was designed in order to prove on a large-scale basis the efficacy of oral photochemotherapy (PUVA) in the prevention of polymorphous light eruption (PLE), to work out indication criteria for PUVA treatment of this disease, and to establish a simple method based on anamnestic data to differentiate UVA from UVB induced PLE. The results obtained in 106 PLE patients (85 UVA-, 21 UVB-induced) demonstrate that: 1) time consuming phototesting for determination of the disease's action spectrum is unnecessary for practical purposes; 2) PUVA-induced tanning under routine conditions represents a potent prophylaxis even in severe cases of PLE; and 3) topical sunscreens ("sunblockers") in the majority of cases are sufficient to protect UVB-promoted PLE, but fail in UVA-induced disease. PUVA thus seems the treatment of choice only in UVA-mediated PLE, the action spectrum of the disease at least in most cases being easily discovered from certain anamnestic data.

Administration, Topical↗
PubMed1983

Annular elastolytic giant cell granuloma.

Annular elastolytic giant cell granuloma (AEGCG) is a clinical and histological entity, which has been described previously in various different terms. Knowledge of AEGCG is of importance, since its misdiagnosis may lead to improper therapy; e.g. longterm tuberculostatic or corticosteroid treatment. In the present paper two patients with typical AEGCG are described and the clinical and histological differential diagnosis is discussed in detail.

Aged↗