Search PubMed⌕ Search

Biomedical subjects

F Grignani

Publications and source records attributed to F Grignani.

At least 181 records · Page 10Linked to original sources
PubMedDate not supplied

Metastatic spindle cell carcinoma: a complete response induced by cisplatin and 5-fluorouracil.

A patient with biopsy-proven spindle cell carcinoma, of unknown primary site, metastatic to the neck and to the lung, was treated with chemotherapy consisting of cisplatin (20 mg/m2/day) on days 1-5 and 5-fluorouracil (1000 mg/m2/day) on days 1-5. The regimen was repeated every 28 days. The patient had a complete response confirmed by computerized tomography. The patient is in a disease-free status 12 months after diagnosis. Toxicity was mild. To our knowledge, this case represents the first chemotherapy induced complete response documented in this rare entity.

Adult↗
PubMedDate not supplied

Systemic lupus erythematosus following total body irradiation for malignant lymphoma.

A case of a 63-year old man, who developed systemic lupus erythematosus three years after an initial diagnosis of small-cleaved centrofollicular lymphoma is described. The diagnosis of SLE was made on the basis of the accepted "1982 revised criteria for the classification of SLE". The autoimmune disease arose after a cycle of total body irradiation, despite the treatment with combination chemotherapeutic doses such a CVP or COAP or Cyclophosphamide, Vincristine, VM-26 and Prednisone. Genetic, immunological and exogenous environmental factors may co-exist and might equally be implicated in the pathogenesis of SLE and malignant lymphoma. However, the onset of SLE after total body irradiation could have been caused by the inactivation of suppressor T lymphocytes, which are known to be sensitive to radiations in vitro.

Antineoplastic Combined Chemotherapy Protocols↗