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Biomedical subjects

F Gotoh

Publications and source records attributed to F Gotoh.

At least 91 records · Page 5Linked to original sources
PubMed1980

Effects of nimodipine (Bay e 9736) on cerebral circulation in cats.

The response of feline pial arteries to i.v. administration of isopropyl-(2-methoxyethyl)-1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate (nimodipine, Bay e 9736) was studied by means of the vidicon camera system developed in our laboratory. Pial arteries showed a dose-dependent dilation with a reduction of systemic arterial blood pressure in the dose range of 0.001 mg/kg to 0.1 mg/kg of nimodipine. The dilatory response was more marked in the smaller arteries (< 100 mu) than in the larger ones (greater than or equal to 100 mu).

Animals↗
PubMed1979

[A case of bilateral spontaneous external carotid-cavernous fistulae with intrahepatic gallbladder (author's transl)].

A 55-year-old female presented bilateral external ophthalmoplegias and a hypesthesia in the left face and then an intracranial bruit, bilateral conjunctival injections and bilateral chemosis. In her past history, there were right retinal hemorrhage, diabetes mellitus and hypertension but no cranial trauma. The arteriographical aspects were almost identical in both sides: selective external carotid arteriography revealed an opacification of the cavernous sinus through the ascending pharyngeal artery, the accessory meningeal artery and the middle meningeal artery, but the internal carotid arteries and the vertebral arteries did not participate in these fistulae. The association in our case of spontaneous external carotid-cavernous fistulae with intrahepatic gallbladder derived from a developmental arrest in the early stage of embryonic life suggests that spontaneous external carotid-cavernous fistula is derived from communications between extra-cranial vessels and the sinuses in the early stage of embryonic life.

Arteriovenous Fistula↗
PubMed1978

Tolosa-Hunt syndrome. Arteriographic evidence of improvement in carotid narrowing.

Diagnosis of Tolosa-Hunt syndrome was made in a 25-year-old woman on the basis of unilateral third and sixth nerve paresis and possible involvement of the first branch of the ipsilateral trigeminal nerve, accompanied by headaches and ocular pain, which responded promptly to corticosteroid administration. Irregular narrowing of the right carotid siphon and occlusion of the homolateral superior ophthalmic vein were observed. During steroid therapy this stenosis improved in association with almost complete clinical recovery, although the vein was not recanalized. Of ten reported cases with contrast radiographic abnormalities, including our own, only two showed pupillary involvement. We hypothesize that the third nerve paresis with pupillary sparing in this syndrome may be attributable to the same underlying mechanism as that of diabetic ophthalmoplegia.

Adult↗
PubMed1978

Chemical control of cerebral circulation. Modification by a new vasodilator (YC-93).

This study was undertaken to investigate influences of a new vasodilator, YC-93, a derivative of 1,4-dihydropyridine, on cerebral circulation and cerebrovascular CO2 reactivity. Cerebrocortical PO2, cerebrocortical PCO2, cerebrocortical blood flow and arterial blood pressure were continuously recorded by means of a PO2 electrode, a PCO2 electrode and a plate-type crossed thermocouple flowmeter placed on an exposed pial surface of the cat brain. The changes in each parameter induced by YC-93 were compared with those induced by papaverine hydrochloride. The effects of 5% CO2 inhalation were compared before and after the intravenous injection of YC-93. YC-93 (0.01 mg/kg) showed a more marked and longer-lasting hypotensive effect that papaverine (1 mg/kg) and yet produced a significant increase in cerebrocortical PO2. After the administration of YC-93, the degree of the increase in cerebrocortical PO2 during 5% CO2 inhalation was reduced significantly in comparison with that before the administration. The above data indicates that YC-93 has a vasodilating effect on cerebral blood vessels and that the drug causes a decrease in cerebrovascular CO2 reactivity.

Animals↗
PubMed1978

Photoelectric method for estimating hemodynamic changes in regional cerebral tissue.

A new photoelectric method for measuring hemodynamic changes in a thin layer of cerebral tissue in situ is described. The apparatus consists of a miniature lamp of 0.7 mm OD and a photodiode with a color filter having maximum light transmission at 548 nm. The lamp was chronically or acutely implanted into the brain tissue of animals as a light source, and the intensity of the light transmitted through the cerebral tissue was monitored with the photodiode from the brain surface. The intensity of the transmitted light was quantified for cerebral blood volume (CBV). The mean transit time of blood (t) was obtained from tissue hemodilution curves produced by saline injection into the carotid artery. The regional blood flow was calculated from the values of CBV and t according to the Stewart-Hamilton equation. The apparatus was shown to be stable, rapid in response, easy to operate, and to give reproducible results. Possible sources of error are discussed.

Animals↗
PubMed1977

Toxic neuropathy as a complication of thiophenicol therapy.

Two cases with sensory neuropathy due to thiophenicol therapy are reported. Thiophenicol neuropathy is hitherto unreported in literature published in English. Neurological manifestations of these cases were similar to those of chloramphenicol neuropathy, but rather marked impairment of position sense in the lower extremities was characteristic. Thiophenicol neuropathy reported in Japanese literature was reviewed and it is concluded that thiophenicol administered in large doses (70-150 g) or for long periods (more than 3-5 months) appeared to have a toxic effect on the nervous system.

Adult↗