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Biomedical subjects

F Goto

Publications and source records attributed to F Goto.

At least 181 records · Page 10Linked to original sources
PubMed1975

Effect of a new vasodilator (flunarizine) on the cerebral circulation.

In order to clarify the effects of flunarizine, a newly-synthesized derivative of piperazine on cerebral circulation and metabolism, cerebrocortical oxygen tension, carbon dioxide tension and cerebrocortical blood flow were continuously recorded, along with a simultaneous monitoring of arterial blood pressure in 11 cats. Maximal changes in cerebrocortical oxygen tension induced by intravenous administration of flunarizine (0.6-1.0 mg/kg) were compared with those of papaverine hydrochloride (1 mg/kg). Flunarizine caused increases in cerebrocortical oxygen tension as well as cerebrocortical blood flow and a decrease in cerebrocortical carbon dioxide tension despite a fall in blood pressure, indicating an increase of cerebral blood flow presumably due to cerebral vasodilatation. Since the increase of cerebrocortical oxygen tension induced by flunarizine was comparable to that induced by papaverine, it was concluded that flunarizine appears to be a potent vasodilator of cerebral vessels.

Animals↗
PubMed1975

Transport of sugars and amino acids in bacteria. XIII. Mechanism of selective inhibition of the active transport reactions for proline, leucine, and succinate by zinc ions.

A mutant (S-1) of Escherichia coli which lacks succinate dehydrogenase [EC 1.3.99.1] but has normally succinate transport system, and various oxidase activities other than succinate, was isolated from the strain U24. Using these strains studies were made on the effects of zinc ions on the active transport reactions for succinate proline, and leucine. Zinc ions inhibited succinate transport reaction and succinate oxidation by intact cells. The active transport reaction for proline, which was supported by endogenous energy source in intact cells, was slightly inhibited by zinc ions. This inhibition was not reversed by large excess of magnesium ions. The initial rates of active uptakes of proline were increased by exogenous energy sources such as succinate and glycerol and zinc ions greatly inhibited these. However, D-lactate dependent proline uptake was enhanced slightly by the presence of zinc ions. It was found that zinc ions at a high concentration enhanced the steady level of proline accumulation in cells. This mechanism was studied in detail and we concluded that zinc ions inhibited completely the exchange-exit reaction for proline. Effects of zinc ions on the active transport reaction for leucine were rather simple when compared with these for proline. Zinc ions inhibited strongly the initial rates of leucine uptakes which were driven by endogenous and exogenous energy sources. The ions also inhibited the exchange-exit reaction.

Biological Transport, Active↗