A 69-year-old woman was admitted to the hospital with meningitis due to Streptococcus pneumoniae. The strain was susceptible to penicillin but intermediate to cefotaxime. In Europe the decrease of susceptibility generally pertains more to penicillin than to cefotaxime. Such a strain is perhaps a forewarning of the existence of high-level cephalosporin-resistant strains. Despite the possible detection of the resistance by oxacillin disk, it underlines the need to determine the MICs of different beta-lactams without delay and to choose the most efficient treatment.

Aged↗

PubMedDate not supplied

Genetic basis of trimethoprim and O/129 resistance in Vibrio cholerae.

Because of its important consequences on prophylaxis and therapy of cholera and on bacterial identification, we have studied the genetic basis of cross-resistance to trimethoprim and O/129 of strains of Vibrio cholerae O1 independently isolated in Africa. Two classes of bacteria were found. In the first class, the strains were also resistant to ampicillin and kanamycin and to high levels of streptomycin by synthesis of a 3"- or 6-aminoglycoside phosphotransferase. The strains hybridized weakly with a Tn7 probe and all the resistance characters were transferable en bloc to Escherichia coli. The second class included strains which, in addition to trimethoprim and O/129, were resistant to moderate levels of streptomycin and spectinomycin by production of a 3",9-aminoglycoside-aminocyclitol adenylyltransferase. The resistance characters were not self-transferable to E. coli and the host strain hybridized strongly with Tn7. It therefore appears, that both plasmids and transposons are responsible for the dissemination of resistance to trimethoprim and O/129 in Vibrio.

Anti-Bacterial Agents↗

PubMedDate not supplied

Plasmid-mediated beta-lactamase (TEM-7) involved in resistance to ceftazidime and aztreonam.

TEM-7, a novel TEM-type beta-lactamase (pI 5.41) encoded on a plasmid of approximately 85 kilobases, was found in a clinical isolate of Citrobacter freundii. Strains containing this enzyme exhibited decreased susceptibility to ceftazidime (64-fold) and aztreonam (16-fold) but not to other third-generation cephalosporins. Addition of a beta-lactamase inhibitor--clavulanic acid, sulbactam, or YTR 830--restored normal susceptibility to associated compounds such as ampicillin, piperacillin, ceftazidime, and aztreonam. DNA-DNA hybridization of an intragenic probe of TEM-1 occurred with a 19-kilobase EcoRI fragment of the plasmid encoding TEM-7. A TEM-2 derivative, TEM-201, with characteristics similar to those of TEM-7 was selected spontaneously in the presence of ceftazidime in vitro.

Aztreonam↗

PubMedDate not supplied

[Kingella kingae osteomyelitis].

A case of Kingella kingae osteomyelitis characterized by an early onset of cellulitis, positive blood culture and negative bone scintigraphy is reported. Exclusive of vertebral involvement, eleven cases have been described in the pediatric literature. The bacterial nature of this disorder may prove hard to demonstrate since fever, leucocytosis, and increased CRP levels are inconstant. The difficulties of isolation and growth of Kingella kingae as well as its likely resistance to antistaphylococcal agents constitute the main features of this type of infection.

Bacterial Infections↗

PubMedDate not supplied

A comparative study of the effects of methaqualone and glutethimide on sleep in male chronic insomniacs.

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Adult↗

PubMedDate not supplied

[Periprosthetic popliteal abscess caused by Listeria monocytogenes].

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Aged↗