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Biomedical subjects

F Gold

Publications and source records attributed to F Gold.

134 records · Page 8Linked to original sources
PubMedDate not supplied

[Fate of orally administered antibiotic sensitive "Escherichia coli" in the intestine of the newborn (author's transl)].

In an intensive care unit, 14 newborns, without antibiotic intake, received orally 1 ml of culture broth from an antibiotic-sensitive strain of Escherichia coli marked with resistance to sodium azide. The purpose was to study the fate of the E. coli administered and to determine whether an interaction was obtained between that strain and antibiotic-resistant enterobacteria in the gut flora. In 3 infants the strain administered developed and was the only enterobacterium excreted during the first week; in 4 others the strain was recovered during one week or more, in quantities greater than 10(6)/g of stools. In 6 others, the strain appeared for less than one week, and/or in quantity less than 10(6)/g of stools. In 1 child the strain could not be recovered at all. These data show what is obtained in "holoxenic" newborns in spite of challenge with many other bacteria. They have been obtained with an ubiquitus E. coli and can be used as a control for further studies.

Age Factors↗
PubMedDate not supplied

[Guidelines for antibiotic therapy in an infectious risk unit].

This surveillance made possible an immediate check up for an appropriate use of guidelines, allowing an optimal usage of antimicrobial agents. It's interest at term is to document audits (yearly for example) to discuss the effectiveness of our guidelines and, if necessary, to make new therapeutic choices, proven to be effective after investigation for clinical and microbiological data. Our surveillance system can be easily investigated by the physicians. It consists in checking on a weekly sheet all the new antimicrobial therapy courses, with name of patient, age, cause of antimicrobial therapy and hospitalization, bacteria, antibiotics used, for infection, before superinfection, previous superinfection, prophylaxis. A shift in usage of antibiotics can be observed, with consequences in antimicrobial therapy and hospital hygiene.

Ampicillin↗
PubMedDate not supplied

[Eradication of Candida from a premature infant unit].

To eradicate Candida from a neonatal unit the authors used increasingly strigent protocols of prophylaxis and treatment. Finally all carriers were identified and treated with nystatin. A strict routine for washing hands was introduced. As a result of these measures the cross infection rate within the hospital was very low (3%). The eradication was maintained by constant surveillance (weekly oral and rectal swabs) because of regular reintroduction of Candida by babies who had been infected before transfer to the unit. The other conclusions were that post natal infection is usually due to cross infection and rarely from mother. The gut and perianal skin are important reservoirs of infection. Erythema of the buttocks almost disappeared after the eradication of Candida. Guteal erythema commonly preceded of manifestations of Leiner's disease.

Candidiasis↗
PubMedDate not supplied

[Gastroesophageal reflux after the surgical treatment of esophageal atresia].

The experience of the authors concerns 100 neonates treated for esophageal atresia between 1968 and 1980. A retrospective study of the sequelae observed in 73 survivors (age 3 to 15 years) found 26 cases of gastroesophageal reflux. This study demonstrates a high incidence of reflux in children who initially presented with a fistula and long gap esophageal atresia. It also shows that chronic respiratory disorders are more frequent in these patients and that esophagitis is the principal factor leading to stricture of the anastomosis stubborn to dilatation. In 14 patients, the severity of the clinical and endoscopic symptoms justified a surgical antireflux procedure, the only guarantee of clinical and radiologic recovery, with long term confirmation in 9 patients.

Adolescent↗
PubMedDate not supplied

[Use of phenobarbital by the oral route in the acute and maintenance treatment of convulsions in children].

Early and long-lasting phenobarbital plasma levels were obtained by the following schedule in children presenting with convulsions who remained at risk for early relapse: a load dose of 15 mg/kg, followed 12 hours later by the administration of 5 mg/kg in children under 1 year of age and 3 mg/kg in older children; further maintenance doses were 3 mg/kg every 24 hours for 10 days in all children. No child presented with any convulsion in the period of time studied. The mean phenobarbital plasma levels were, from the 1st to the 88th hour, between the values considered as effective (12.6 and 22.3 mg/l). These values were always lower in children under 1 year of age, except for the 1st hour.

Administration, Oral↗