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Biomedical subjects

F Goglia

Publications and source records attributed to F Goglia.

60 records · Page 4Linked to original sources
PubMed1976

Modification of nucleic acid levels per mitochondrion induced by thyroidectomy or triiodothyronine administration.

The authors have determined the liver mitochondrial population (number of mitochondria/nucleus) in young rats, which has been thyroidectomized (T) or thyroidectomized and subsequently treated with triiodothyronine (T3). They have observed that thyroidectomy decreased such a population to 72.3% with respect to the normal one, while the T3 administration (at the dose of 10 mug/100 g body weight every second day, from day 50 to day 60 of age) restored the mitochondria number to 81.8% of normal ones. The average levels of proteins per mitochondrion were 8.90 X 10(-13) g in the liver of normal 60-day-old rats. This content was doubled in T rats of the same age while the levels of nucleic acids or the nucleic acid polymerase activities per mitochondrion were enhanced, notwithstanding that the specific values (referred to mg mitochondrial protein) decreased. The T3 administration severely lowered the content of protein per mitochondrion, and this may indicate that thyroid hormones control the normal assemblage of mitochondrial protein.

Age Factors↗
PubMedDate not supplied

Thyroid state and mitochondrial population during maturation and ageing.

The authors have determined the serum thyroid hormone levels [total and free triiodothyronine (T3), thyroxine (T4)], the liver T3 content, the mitochondrial alpha-glycerophosphate dehydrogenase activity (alpha-GPDH) and the number of mitochondria per cell in the rat from birth to old age. The serum levels of both thyroid hormones are modified with maturation and ageing in an essentially similar way: they increase from low values at birth to remarkably high values around 12 days, and then remain constant. The T3 liver content firstly increases (from birth to 14 days of life) and then maintains constant values. During the first two postnatal weeks, therefore, free serum T3 and liver T3 display a similar behavior. The alpha-GPDH activity of liver mitochondria was found constant from birth to old age. This might suggest either that the control of the alpha-GPDH activity is, at birth, under complex hormonal control, or that the nuclear receptors associated with the alpha-GPDH genes are precociously synthesized. The number of mitochondria per cell, at birth, is half the adult values, strongly increasing in number at weaning and remaining constant afterwards. The effect of thyroid hormones on the mitochondrial population during maturation, when low levels of serum T3 and T4 occur naturally, appears to be quite different from that induced experimentally by thyroidectomy.

Aging↗
PubMedDate not supplied

[Sealing of occlusal surfaces in preventodontics].

The Authors, helped by S.E.M., examine the validity of the sigillature, as prophilactic measure against the formation of carious process. Tests effectuated on 100 patients' teeth show this therapy efficaciousness.

Adhesiveness↗