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Biomedical subjects

F Gloor

Publications and source records attributed to F Gloor.

At least 37 records · Page 2Linked to original sources
PubMed1983

Renal papillary morphology in adults.

Renal papillary morphology and distribution have been analysed endoscopically in 50 adult autopsy kidneys. Concave papillae of the refluxing type were found with greater frequency in the adult kidneys than had been reported by others in children. A further type of calyx lacking a true papilla, not previously described in children, was occasionally observed. It therefore seems doubtful that all pyelonephritic scars detected at autopsy in adult kidneys have arisen during infancy. Further studies will be required to elucidate the role of papillary morphology in the pathogenesis of adult pyelonephritis.

Female↗
PubMed1983

Epithelioid sarcoma.

Epithelioid sarcoma is a malignant soft tissue tumor characterized by its propensity to occur in the distal extremities as a nodular lesion and its slow and asymptomatic growth. Microscopically, the diagnosis is difficult. Therefore the interval between onset of symptoms and diagnosis averages one to three years. 10 years survival after onset are not uncommon whatever the treatment chosen. Having to treat such a tumor of a hand, 8 years after onset, we decided a local radical excision by micro-surgery instead of amputation or mutilating excision. Long standing clinical follow-up will add valuable information as to the cure of the upper extremity.

Adolescent↗
PubMed1982

[Secondary malignancies after breast cancer surgery. Comparison of retro- and prospective findings].

Second malignancies (SM) represent one of the potential hazards of modern cancer treatment and especially of radio- and chemotherapy after surgery for breast cancer. For this reason, regional tumor registry data (1960-1975) on 1985 breast cancer patients were analyzed for SM in the retrospective part of our study. These data were compared with the prospective part of the study in which 241 patients were randomly assigned to either mastectomy or mastectomy and chemoimmunotherapy (CT + IT). In the retrospective part of the study, SM were observed in 83 cases (4.2%), 49% of which were SM of the contralateral breast. Most frequent extramammary SM were of gastrointestinal (25%), gynecologic (8%) and cerebral (5%) origin. Leukemias were found in 4% of all SM. Median time interval to SM was 5 years and 1 month. Within 5, 10 and 15 years after mastectomy 60%, 85% and 95% of SM were observed respectively. Median survival of patients with SM was 6 1/2 years. In the prospective part of the study, SM were observed in 9 cases (3.7%), 4.1% in the surgical control group and 3.4% in the adjuvant CT + IT group with a median observation time of 6 years post mastectomy. These data are compared to other current adjuvant breast trials and do not indicate as of now an increase in SM under present adjuvant therapy.

Adult↗
PubMed1982

[The neuroendocrine Merkel cell carcinoma of the skin].

Seven primary skin tumors from 5 women and 2 men were analyzed by light and electron microscopy and immunocytochemistry. The tumors were localized on the face (3 tumors) and on the extremities. The maximum diameter was between 1 and 3.5 cm. Two tumors metastasized to the regional lymph nodes 4 months after excision of the primary, 1 tumor metastasize to the regional lymph nodes after 5 years and the patient died of multiple metastases 8 years after excision of the primary on the forearm. No local recurrences developed. The tumors occurred in the dermis with frequent infiltration of the subcutaneous tissue. The epidermis was intact. The tumor cells formed large solid clusters, while their cytoplasm was faintly basophilic and formed a small rim round the large pale nucleus. In electron microscopy many cells displayed cytoplasmic electron-dense secretory granules with a mean diameter of approx. 100 nm. Immunocytochemistry showed that a large number of cells in all tumors contained neuron specific enolase and many cells of 4 tumors yielded formaldehyde-induced fluorescence. The tumors are therefore of neuroendocrine origin and may derive from merkel cells. They frequently give rise to erroneous diagnosis of metastasis of carcinoma or malignant lymphoma to the skin.

Aged↗
PubMed1981

[Lymph node metastases of unknown primary tumors. Sense and nonsense of a complicated search].

Malignant neoplasms are quite frequently (5% in our material) first diagnosed from their metastases. Detecting the site of the primary usually involves a time-consuming and costly work-up unpleasant for the patient. In a retrospective analysis of 60 cases of supraclavicular, cervical and axillary lymph node metastases, an attempt is made to establish guidelines for more economical and rational investigation. The most important but often neglected leads are provided by history and physical examination. Routine laboratory and X-ray examinations only rarely contribute to rapid detection of the primary. Histological examination of the excised lymph node is very reliable in suggesting possible primaries. A practical guide is given for the approach to a patient with lymph node metastasis of an unknown primary, based on a limited initial work-up and on the histology of the lymph node.

Adenocarcinoma↗
PubMed1981

[Un- classifiable types of ulcerative colitis].

10-15% of cases of non-specific inflammatory bowel disease cannot be classified. In a retrospective study of 35 colectomy specimens during a ten-year period, we observed 5 such cases. These cases of so-called "unclassified colitis" or "indeterminate colitis" nearly always follow, a fulminating course and require urgent surgery. On macroscopic examination there is marked dilatation of the colon with perforations. The colon is continuously involved, the right colon sometimes more so. Microscopically there is transmural inflammation with acute fissuring and extensive ulcerations. No specific criteria of ulcerative colitis or Crohn's disease are present. "Unclassified colitis" is not a definitive diagnosis. Followup studies sometimes serve for final classification of a case.

Adult↗
PubMed1980

[Malignant non-Hodgkin lymphoma of the stomach (author's transl)].

Between 1970 and 1978 467 malignant non-Hodgkin lymphomas were newly registered by the St. Gallen-Appenzell cancer registry. Among these 23 (4.9%) were primary gastric lymphomas. Among the necropsy material between 1970 and 1978 23 patients (15.6%) were observed with secondary gastric involvement among 147 generalised malignant non-Hodgkin lymphomas. Among the 23 patients whose malignant lymphomas were investigated by use of gastric resection specimens 10 were in clinical stage IE at the time of operation, the other 13 were in stage IIE. Macroscopically there was an uncharacteristic picture of these tumours which were frequently localised in the antrum and ulcerated in most cases. Histologically 19 cases had diffusely growing malignancy. Four tumours showed nodular or follicular structures. Histiocytic and immunoblastic (n = 14 and 13, respectively) forms were the most frequently occurring malignant lymphomas. The diagnosis of malignant lymphoma in biopsy material could only be verified in 4 out of 12 patients investigated preoperatively by gastroscopy. Histological typing of the lymphomas was not possible in most cases. When there is a suspicion of malignant lymphoma macroparticle biopsies should be performed.

Adult↗
PubMed1980

[Does the intramammary carcinomatous lymphagiosis have prognostic significance in nodal-negative breast neoplasms?].

This study represents an attempt to analyse the prognostic significance of intramammary lymphangiosis carcinomatosa (ILC) in nodal-negative mammary carcinomas. It is based on 125 cases of nodal-negative mammary carcinomas covered by the prospective OSAKO study (reference number 06/74). Histological sections of the mastectomy preparations were examined for the presence of ILC. We found it difficult to diagnose the presence of lymphangiosis carcinomatosa in mammary gland tissue in cases of mammary carcinoma on the basis of histological findings. Applying strictest criteria, ILC was found in 11 of the 125 cases (8.8%). Due to the small number of carcinomas with ILC and to the average observation period of only 3 1/2 years it is as yet impossible to reach any statistically significant conclusions regarding rate of relapse, appearance of distant metastases and deaths. It is, however, striking that 2 of 11 patients with ILC died as a result of their carcinomas, whereas there were only 3 carcinoma deaths out of 107 cases in the group without ILC. It is at present too early to decide whether ILC is an appropriate criterion to use in selecting cases of nodal-negative mammary carcinoma with a poor prognosis, meriting the administration of adjuvant chemotherapy.

Breast Neoplasms↗
PubMed1980

Familial glomerulopathy with giant fibrillar deposits.

Proteinuria and microhaematuria were observed in three siblings and one first-degree cousin. Histological examination of three kidney biopsies and one autopsy specimen shows the same diffuse glomerular lesions in all patients, characterized by mainly subendothelial but frequently transmembranous and mesangial deposits of a unique fibrillar structure, visible by electron microscopy. Examination by immunfluorescence gave inconstant findings. No serological abnormalities could be established. To our knowledge, such a pecular form of familial glomerulopathy has not been described so far.

Adult↗
PubMed1980

Gardner's syndrome with glandular cysts of the fundic mucosa.

The present study describes a family (mother and son) with Gardner's syndrome. Aside from the classical findings, gastric polyposis was found; histologically glandular cysts of the fundic mucosa were diagnosed. The occurrence of gastric polyps in Gardner's syndrome has recently been described with increasing frequency. These lesions have various histological aspects. A number of authors have noted several cases of Gardner's syndrome with glandular cysts of the fundic mucosa, but to our knowledge this is the first case of familial occurrence.

Adult↗
PubMed1979

[Histopathologic classification of malignant melanoma of the skin. Retrospective study of 149 cases].

In a retrospective study, the histological slides of 149 cutaneous melanomas are classified according to CLARK et al. (1969) into four levels of dermal invasion and three types of melanoma. Simultaneously, the depth measured in millimeters is added in a slightly modified version of BESLOW's method. This demonstrates the practicability of CLARK'S classification with only a few routine sections. The presumptions are (1) The tumor must be cut through its largest extension. (2) The bordering parts of the lesion in the epidermis must be examinable. (3) The specimen must be excised down to the subcutaneous fat. (4) Beside the Hämalaun-Eosin stains, a Van Gieson Elastica stain should be available to determine the level of invasion. Although it is easy to recognize level V, it is difficult to distinguish level II from III or III from IV in some cases. Our material, as compared to the literature, contained more nodular melanomas and lesions of levels IV and V. The reasons for this are discussed. The prognosis of nodular melanomas is worse than that of superficial spreading melanomas even when they are classified into the same level of invasion. A good correlation between the survival rate and the level of invasion is shown. In addition, the prognostic value of the histological staging can probably be optimized by measuring the vertical extent of the lesions in millimeters.

Humans↗