A case of prolonged, though reversible procaine-induced Parkinsonism treated with l-dopa and trihexyphenidyl (Artane-Sustets) is reported. A pathophysiological explanation is discussed on the basis of recent theories concerning the transmitter systems of the basal ganglia.

Chronic Disease↗

PubMed1969

Transitory cortical blindness in head injury.

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Adolescent↗

PubMed1966

[Decubitus. A new form of prophylactic pillow (Decubitex)].

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Aged↗

PubMed1966

Poisoning with chlordiazepoxide (Librium).

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Adolescent↗

PubMedDate not supplied

Automated image analysis, histologic malignancy grading, and survival in patients with astrocytic gliomas. Prognostic significance of nuclear count and nuclear area fraction.

A number of morphometric and densitometric parameters, obtained by automated image analysis, correlate fairly well with classic histologic grading of malignancy in astrocytic gliomas. In this study the predictive value of classic histologic grading of malignancy and of two automatically retrieved nuclear parameters are compared in 199 patients treated surgically for an astrocytic glioma. A 100% follow-up was obtained. Nuclear count and nuclear area fraction correlated fairly well with survival. In patients with 25% of the lowest values of nuclear count and nuclear area fraction 5-year survival was 40%. In patients with 25% of the highest values, less than 5% survived. In contrast, subdivision of the glial tumors into four malignancy grades gave an even better prognostic accuracy. In patients with gliomas of malignancy grade I, about 60% survived for more than 15 years; in malignancy grade IV, no patients survived for more than 5 years.

Adolescent↗