Survey of several red cell and serum genetic markers in a Peruvian population.
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Acid Phosphatase↗
Biomedical subjects
F Gigliani
Publications and source records attributed to F Gigliani.
Double satellites: autoradiographic study of a chromosomal marker observed in two generations.
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Adult↗
Red cell phosphoglucomutase polymorphism. I. Enzyme activity of different red cell PGM phenotypes.
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Electrophoresis↗
Red cell phosphoglucomutase polymorphism. II. Densitometric studies.
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Alleles↗
Gene frequencies of adenylatekinase polymorphism in the Roman population.
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Adenine Nucleotides↗
The pR plasmid: a tool for discriminating between DNA lesions induced by different types of cytotoxic agents in cultured mammalian cells.
The LA-D cells, obtained by cotransformation of LTA mouse cells (tk- aprt-) with pR plasmid and with tk gene as selective marker, are significantly more resistant to UV light and 4-nitroquinoline-N-1-oxide than LTA control cells. In this work, we report that the LA-D cells exhibit different degrees of response to various DNA-damaging agents: wild-type survival to mitomycin, increased sensitivity to bleomycin, cis-diamminedichloroplatinum and N-methyl-N'-nitro-N-nitrosoguanidine. The pR plasmid could, therefore, play an important role in the DNA-repair mechanisms that modulate the cytotoxic effect of the DNA-inhibitory agents. The possible interactions between pR plasmid products and the different repair enzymes involved are discussed.
Animals↗