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Biomedical subjects

F Gentile

Publications and source records attributed to F Gentile.

At least 91 records · Page 5Linked to original sources
PubMed1986

Relationship between brain gonadotrophin-releasing hormone (GnRH) and seasonal reproductive cycle of "caribe colorado," Pygocentrus notatus.

Immunoreactive gonadotrophic hormone-releasing hormone (ir-GnRH) was detected in hypothalamic and telencephalic extracts of the Venezuelan freshwater fish "caribe colorado," Pygocentrus notatus. Hypothalamic ir-GnRH from female fish demonstrated displacement curves parallel to those of synthetic mammalian luteinizing hormone-releasing hormone (LHRH). The content of hypothalamic and telencephalic ir-GnRH from female fish was more than four-fold greater than that of male animals. Also, fluctuations that depended on the reproductive state and environmental conditions (rainfall) occurred in females but not in males. Thus, ir-GnRH levels were higher in hypothalamic and telencephalic extracts from sexually mature females than in those from fish sampled outside the climatically determined breeding season.

Animals↗
PubMed1986

[Skeletal changes caused by etretinate].

A patient of 4 years of age, male is presented, that suffered from generalized pustulous psoriasis. The small response to prednisone and the aggravation of the symptomatology motivated the use of etretinate, in the dose of 1 mg/kg/day during six months obtaining the remission. Two years later he was seen again having minimal lesions of periumbilical psoriasis, observing delay in the growth, and in the radiological exam: periostic separation in the inferior part of femur, modeling alteration of the metaphysis, diffuse demineralization, slender bone, and a bone age of one and a half year. The authors advise over the necessity of controlling children that must receive etretinate, with clinic and periodic radiological exams.

Bone Development↗
PubMed1985

[Study of the regional contraction of the left ventricle in normal subjects using a two-dimensional echocardiographic technic].

The purpose of this study is to evaluate normal left ventricular regional wall motion pattern in order to answer the two following questions: does wall motion change at different levels of the left ventricle from the base to the apex? does wall motion change among different segments at the same level? Seventy-two normal subjects were submitted to a cross sectional echocardiographic examination and the tape recordings were analyzed by a computerized system. Parasternal short axis views at mitral valve and papillary muscles level were chosen and divided by the computer in 16 areas which were fitted to a more anatomical division, i.e. interventricular septum, anterior, lateral, posterior-lateral, inferior-posterior and inferior walls. From each segment, fractional area changes were obtained. Statistical analyses were carried out by the two way analysis of variance and two paired t test. Wall motion pattern of the normal left ventricle is not uniform either at different levels or among segments at the same level: we conclude that regional wall motion differences of the left ventricle are not necessarily due to abnormal conditions, but might be a normal left ventricular pattern.

Adolescent↗
PubMed1984

Exercise-induced arrhythmias: angiographic correlation and follow-up.

The meaning of exercise-induced arrhythmias was studied in 409 patients who underwent a maximal treadmill test, coronary and ventricular angiography and were followed for 31 +/- 10.6 months. The original population consisted of 1720 patients, of whom 520 were assigned to a group of known or strongly suspected coronary artery disease (Group I) and 1200 were assigned to a group with low likelihood of coronary artery disease (Group II). This division was based on age, history and symptoms. Two hundred and forty-seven (47.5%) patients of group I and 218 (18%) of group II developed ventricular premature beats during the exercise test or the recovery period. The test was positive in 378 (72.6%) patients of group I and in 190 (15.8%) of group II. A complete invasive angiographic study was performed in 233 (44%) patients of group I and 176 (14.6%) of group 2. Exercise-induced ventricular premature beats (VPBs) predicted neither coronary anatomy nor subsequent coronary or surgical events, but a weak relationship was observed with a lower ejection fraction among group I patients. On the other hand, a positive test was predictive of coronary anatomy in both groups and of coronary events in group I. We conclude that, despite a higher prevalence of exercise-induced ventricular premature beats among patients with definite coronary artery disease, an exercise test presenting ventricular premature beats as the only abnormality should not be classified as positive. Patients with such results require further investigation.

Arrhythmias, Cardiac↗
PubMed1984

[10-year survival after myocardial infarction. Longitudinal study of a hospital population].

In this study, 321 patients discharged from hospital after an acute myocardial infarction were followed for 10 years or until death. Death rate was 46.4% and 30.8% of all fatalities was sudden. In over 80% of the cases death was from cardiac causes and frequently occurred out of hospital. Univariate analysis showed that age, female sex, previous infarction, diabetes, heart failure during hospitalization, heart murmur, NYHA class III or IV, post-infarction angina, intraventricular conduction defects, cardiomegaly, ST displacement, were all associated with an increased death rate. A positive exercise test 6-17 months after infarction, was associated with a 4-fold mortality increase. Bypass played a minor role in this series since only 6.8% of the patients underwent this operation. A nonfatal infarction recurred in 71 patients (22.1%) with an annual rate of 2.2%. Annual death rate after the first 2 years of follow-up was 3.9%, as in most recent reports on survival after myocardial infarction.

Aged↗
PubMed1983

[Biliary ileus. Diagnostic problems].

A case of biliary ileus in association with successfully operated cholecystoduodenal fistula is reported. The importance for prognosis of preoperative diagnosis of the condition is emphasised. The diagnostic importance of echotomography in cases where there is a history of cholelithiasis is underlined.

Aged↗
PubMed1983

[Vesical hernias. Considerations apropos of a case].

A case of inguinoscrotal hernia involving the bladder is presented. This pathology is so frequent in males over 50 that preoperative diagnostic investigations should include retrograde cystography and if necessary urography.

Aged↗
PubMed1982

[Straddling and overriding atrio-ventricular valves: echocardiographic and angiographic findings].

Recent advances in surgical technique for correction of positional abnormalities of atrio-ventricular (A-V) valve require accurate preoperative diagnosis of this malformation which can be distinguished into a complete (overriding + straddling) and a partial form (overriding or straddling). In this study, echocardiography and angiocardiography are shown to be complementary to each other for definition of the anatomic details of this pathology. Six cases of positional abnormalities of the A-V valves are reported. Group I includes three patients with tricuspid valve abnormalities: two are complete forms (overriding + straddling) one of which is associated with DORV and the other is associated with d-TGA. The third patient is a partial form: straddling tricuspid valve with only a large ventricular septal defect involving the inlet septum. Group II includes three patients with mitral valve abnormalities: one complete form and two partial ones (straddling), all associated with DORV. We illustrate the best echocardiographic and angiocardiographic projection for the recognition of A-V valve malposition and demonstrate that both techniques greatly add to the diagnostic accuracy. Echocardiography defines better the abnormal attachments of the leaflet apparatus, whereas angiocardiography identifies better the displacement of the A-V valve annulus.

Angiocardiography↗
PubMed1981

Prostacyclin effect on cardiovascular system in man evaluated by echocardiography.

This was an echocardiographic study of the cardiovascular effects of prostacyclin (PGI2) infused intravenously to human volunteers at the rate of 20 ng . kg-1 . min-1 for 10 minutes. The following parameters were recorded in the steady state, at one-minute intervals throughout infusion and the ensuing recovery period: systolic, diastolic, and mean blood pressure (SBP, DBP, MBP); heart rate (HR); left ventricle end-diastolic (EDD) and end-systolic diameter (ESD); stroke volume index (SVI); cardiac index (CI); peripheral vascular resistance (PVR); left ventricle fractional shortening (FS) and ejection fraction (EF). We detected a progressive reduction of MBP without any HR modification. MBP reduction was associated with a reduction of PVR and a parallel rise of CI and SVI. There was also an increase of FS and EF reflecting a reduced ESD. We conclude that PGI2 infused in man at the rate stated above causes hypotension reflecting an arterial vasodilating effect; a lack of heart rate reflex response to afterload reduction (probably a nerve-mediated effect of PGI2); and no venous vasodilation, judging from the absence of any change in end-diastolic diameter.

Adult↗