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Biomedical subjects

F Gebhard

Publications and source records attributed to F Gebhard.

At least 37 records · Page 2Linked to original sources

[Cost analysis of the treatment of patients with multiple trauma].

Current clinical management after multiple trauma is expensive. The aim of the present study was to quantify the actual costs of inpatient treatment after multiple trauma in a German university hospital, to compare the actual costs with the reimbursement rates, and to identify important determinants of costs. Routine documentation of hospital costs at a patient level was not available. Therefore a method for calculating the costs of resource utilization during clinical treatment of patients was developed. The concept was based on financial and utilization data provided by the hospital administration and patient-specific data. The average costs per case in the study group (mean ISS = 37) were 73.613 DM, maximal costs were up to 292.490 DM. The most costly components were intensive care, accounting for 60%, followed by procedures in the operating room (24%). A comparison with the reimbursement rates resulted in an average loss of 23.211 DM per case. Factors significantly associated with the costs of acute care hospitalization were outcome, injury severity, pattern of injury, blood volume replacement, length of mechanical ventilation, and number of operations. Whereas patient age, CNS state, mechanism of injury, pre-hospital care, and time between accident and hospital admission revealed no effect. Given the current reimbursement rates, multiple trauma care clearly belongs to those categories of care which have to be subsidized within the hospital. Any challenge to the optimal level of care resulting from this should be avoided.

Acute Disease↗

[Limits of CT-based computer navigation in spinal surgery].

Computer-assisted and navigation-based therapeutic tools have found their first application in the field of spinal surgery. Meanwhile, the basic principles have been extended to other procedures, such as screw osteosynthesis of the pelvis and navigation of long bones. Commonly, all procedures except C-arm navigation are based on three-dimensional data sets. Data acquisition and processing as well as planning require specific steps, which should guarantee adequate accuracy and successful navigation. All steps up to intraoperative navigation and potential pitfalls in every part of the interaction are demonstrated, with reasons of undesired results presented.

Bone Screws↗

[Minimal invasive implant removal after retrograde intramedullary nailing of the distal femur].

Recently, the retrograde femoral nailing has become a procedure with increasing acceptance. Indications for the retrograde femur nail are distal femoral fractures including dia- and transcondylar fractures, supracondylar osteotomies and distal periprosthetic femur fractures after total knee joint replacement. Controversial discussion is carried on about the implant removal, which is potentially afflicted with further damage to the knee joint. To minimize the operative damage due to the implant removal, an arthroscopic assisted procedure has been selected. The arthroscopic assisted implant removal was possible in all of our patients. Intraoperatively, 2/3 of the patients showed normal age-related findings of the chondral and meniscal structures. The arthroscopic assisted implant removal is a gentle procedure, which allows minimal invasive extraction of retrograde femur nails and prevents secondary damage to the knee joint due to the otherwise difficult localisation of the implant. The advantages of this procedure concerning gentleness and diagnostic capabilities are as convincing, that we indicate implant removal of retrograde femur nails in all younger patients (< 60 years), except in periprosthetic fractures.

Arthroscopy↗

Spinal cord injury without radiographic abnormalities in children and adolescents: case report of a severe cervical spine lesion and review of literature.

The biomechanics of the child's and juvenile's spine is responsible for the commonly encountered closed spinal trauma with significant neurological injury but without bony or ligament injury (particularly of the cervical spine). The ligamentous laxity and hypermobility of the young bony cervical and thoracic spine predispose to spinal cord injury without radiographic abnormalities. We report a 16-year-old girl with typical features of this type of injury after a "flic-flac" sports injury. We conclude that children and adolescents who have neurological deficits without positive radiographic findings require appropriate diagnostic screening, monitoring, and often a prolonged therapy. The sometimes changing neurological deficits should never be ignored or dismissed as psychogenic affection.

Adolescent↗

Volume replacement in trauma patients within the first 24 h and its impact on the interpretation of biochemical data.

BACKGROUND AND AIMS: Patients of the same and particularly of different trauma studies are primarily incomparable due to different volume replacements. The aim of this prospective study was to analyze the amount of initially administered fluids in trauma patients during the first 24 h and to estimate the impact of dilution on plasma protein concentrations (PPCs) of prostanoids. These substances are vascular endothelium-derived and are thus influenced by blood pressure. PATIENTS/METHODS: Sixty-nine casualties suffering from multiple injuries were enrolled in the study. The amount of any fluid administered was scrutinized during the first 24 h. Patients were divided into subsets according to trauma severity by Injury Severity Score (ISS) (group=G-I: < or = 9; G-II: 10-18; G-III: 19-32; G-IV: >32) and between survivors and non-survivors. At corresponding time points, hemoglobin, hematocrit (Hct) and PPC as well as prostaglandins (PGI, TxA, PGF2a) were evaluated at the site of accident, at hospital admission, and every hour thereafter for the first 24 h. RESULTS: During this period, the total amount of infused fluids ranged between 0.51 (G-I) and >481 (G-IV). The higher the trauma severity, the greater the volume infused (G-III/IV P=0.0003 vs G-I/II). Simultaneously, PPC dropped markedly (P<0.01). Patients who died within 36 h required higher volumes (P<0.003) than survivors. PPC was linearly related (r2=.6685, P<0.001) to Hct. During the first 24 h, the time course of prostanoid concentration was altered when dilution is not taken into account. CONCLUSION: PPC proved a suitable parameter to estimate dilution effects and to adjust plasma concentrations of prostanoids. We recommend that consideration be given to possible dilution effects during the first 24 h when interpreting biochemical data in trauma patients.

Adult↗

Palliation of advanced esophageal carcinoma by photodynamic therapy and irradiation.

BACKGROUND: We wanted to determine the role of photodynamic therapy in a multimodal approach for the treatment of patients with advanced cancer of the esophagus. METHODS: We reviewed the cases of 119 patients with nonresectable esophageal carcinoma who underwent endoluminal palliation. Twenty-one patients required initial dilation and tumor obliteration with a neodymium: yttrium-aluminum-garnet laser prior to therapy. Forty-four patients received photodynamic therapy followed by brachyradiotherapy, and 75 patients were treated with brachyradiotherapy. In both groups, some patients also received external-beam irradiation. RESULTS: Photodynamic therapy produced a significant difference in relieving stenosis caused by tumor stenosis (mean, 6.6 mm; p = 0.0000). The dysphagia score improved by one to three levels in all patients, with a significant difference in favor of PDT (p = 0.0003). The mean number of overall treatment sessions was four (range, one to seven). The rate of major complications was 9.2%. Four esophageal perforations occurred, three after intervention and one spontaneously 5 months later. Four esophagorespiratory tract fistulas developed several months after combined PDT and irradiation. The mean overall survival was 7.7 months, and analysis of variance revealed a significant difference in favor of PDT and external-beam irradiation (p = 0.0129 and p = 0.0001, respectively). CONCLUSIONS: Photodynamic therapy has been shown to be an effective palliative treatment of advanced esophageal cancer. However, proper patient selection is necessary to prevent serious complications.

Adenocarcinoma↗

[Trauma surgery 2020. Developments in the past--challenges and perspectives for the future. I: Trauma surgery management].

In germany over 5 million individuals are involved in an accident annually. The economical consequences are huge with direct treatment cost amounting to approx. 72 billion marks. The available data indicates an increase in the incidence of overall trauma and trauma cases treated in specialised trauma departments. An identical development can be documented for severe trauma, especially for for fractures of the spinal column, whereas the incidence of automobile and occupational accidents has declined in recent years. The current system of reimbursement in the treatment of severely traumatized patients is deficitary for trauma departments. Therefore, to avoid a reduction in the standard of care, new methods of reimbursement have to be devised. In a limited financial environment the benefit of high level trauma care for the individual and the society has to be demonstrated with adequate public relations.

Cost-Benefit Analysis↗

[Trauma surgery 2020. Development in the past, definition of future topics and programs. II. Research in trauma surgery 1998].

The field surgery has been structured into four specialties of equal importance that are Thoracic Surgery, Vascular Surgery, Visceral Surgery and last but not least Trauma Surgery. Each specialty defines its research tasks. Therefore it is necessary to evaluate the situation of research in trauma surgery and define future topics and programs. The aim of this survey was to cover the present research situation in Germany. Out of the 200 questionnaires 112 were available for evaluation. The major deficiencies were stated to be a lack of personnel, budget and coordination of topics and resources. Of general interest was to initiate activities of the German Society for Trauma Surgery (DGU) in view of coordination of research activities, setting up of new funds and integration of teaching hospitals into university research programs. The data, shown in this article, may serve to start a discussion aiming on the improvement of the financial and scientific environment.

Forecasting↗

[Trauma surgery 2020. Past developments - future demands and perspectives. III: Ideas on future care].

A growing number of casualties and the increasing restrictions of funding will lead as a consequence to changes within the field of trauma surgery. Despite these developments trauma surgery must maintain its major responsibility towards the victims of accidents. Therefore the German Society for Trauma Surgery (DGU) has to face the future economic and social challenges to influence the coming changes. This role compromises the engagement in a continuous struggle for the high and global standard of injury care in Germany, for quality assessment, education and training, research and adequate public relations. This paper outlines the aspects and visions of future trauma surgery and the means which may continue to guarantee international acknowledged standard of trauma care in Germany.

Cost Control↗

Ultrasound evaluation of gravity induced anterior drawer following anterior cruciate ligament lesion.

Ultrasound is not so far a standard procedure to visualize the anterior drawer following anterior cruciate ligament (ACL) lesions. This is because the described techniques are either technically difficult or depend on the experience of the performer and are not standardized. The purpose of this prospective analysis on ACL intact, ACL deficient and ACL reconstructed knees was to compare the diagnostic accuracy of prone ultrasonographic Lachman testing with KT-1000 measurements in the same study population. Our technique is based on a prone position of the patient. The thigh lies on the table surface such that the patella has no contact. The lower leg is placed on a roll in the ankle area and flexed to 30 degrees . The transducer (5 MHz) is positioned over the medial aspect of the popliteal fossa to visualize the femoral condyle as well as the tibial head. Under ultrasound control the lower leg is manually lifted as far the thigh stays in contact with the surface defining the start position. The lower leg is then released and drawn by gravity into the anterior drawer position, the final position. The distance between the posterior tangent from the medial femoral condyle to the medial tibial plateau was registered by three independent ultrasound measurements of the injured knee. The uninvolved opposite knee served as an internal control. The same procedure was done using a KT-1000 device (89 and 133 Newton and manual maximum force). The patients were split into two groups: acute injury (A), and (B) 6 months following ACL repair with a patellar tendon graft. All patients then underwent arthroscopy. In group A with acute ACL lesions the anterior drawer resulted in 14.1 mm (+/- 3.5) and was significantly (P < 0.001) different from the contralateral knee (7.7 mm +/- 2.9). The KT 1000 showed a comparable difference with 14.4 mm (+/- 3.9) for the injured knee and 8.3 mm (+/- 3.4) for the uninjured (P < 0.001). Sonometrically, group B patients showed no clear difference between the repaired (9.9 mm +/- 2.7) knee and its control (8.1 mm +/- 2.5). This was found for the KT-1000 results as well. The results derived from the ultrasound evaluation of the anterior drawer correlated well with those from the KT-1000 (r = 0.46). Based on a minimum intra-individual difference of 5 mm in the ultrasound measured anterior drawer, the sensitivity of the test in group A resulted in 0.96, and the specificity in 0.98. The described technique is reproducible, painless and easy to perform in order to evaluate acute ACL tears using any commercially available ultrasound device. The reproducibility is similar to the KT-1000 device. We recommend this technique for use in cases of acute ACL tears as well as in the follow-up of ACL repair.

Adolescent↗

[Disabilities and handicaps due to hip fractures in the elderly].

OBJECTIVE: to examine mortality, mobility, pain, institutionalization rates six month after hip fractures. DESIGN: observational study, non-selected consecutive patients, time-set protocol. SETTING: urban area (population n = 116,5000), five hospitals. PARTICIPANTS: hip fracture patients (n = 214), age 65 + years (mean 82.4 years). MEASUREMENTS: age, gender, prefracture status, operative procedures, complications, comorbidity, cognition (MMSE), depression (GDS), fear of falling, ADL (Barthel) and mobility and pain status (SAHFE protocol). RESULTS: the incidence for this age group was 636.9/100,000, 31.8% were institutionalized elderly. 84% of the patients were female. Pre-existing comorbidity showed a high prevalence of neurodegenerative (cognitive deficits 53. 6%, Parkinson's disease/syndrome 11.2%) and cerebrovascular diseases (16.8%). Six month postfracture, the mortality was 17.6%. From those surviving 76.2% did walk indoors, 58.5% did also walk outdoors. Independent to dress were 54.6%. Severe pain was reported by 10.2%, whereas 36.9% described no pain. The institutionalization rate at six month was 19.0%. CONCLUSIONS: the study showed considerable mortality, a significant loss in function and social disintegration. Considerable differences were observed for subgroups of patients. Future treatment should focus on risk stratification and include postdischarge training programs. Moreover, preventive strategies should be implemented for high risk groups, such as ambulating patients with a history of stroke. Parkinson's disease and syndrome, dementia and nursing home residents.

Activities of Daily Living↗

A new approach to computer guidance in orthopedic surgery using real time volume rendering.

The purpose of this paper was to evaluate the ability of a new real time volume rendering system using raw unprocessed CT data on a four processor Pentium PC. A CT data set of the pelvic area was used to demonstrate the systems ability to integrate and visualize both data from a CT scan and a tracking system. The computer system consisted of a four processor Pentium PC and the software tool VGInsight (Volume Graphics GmbH). For study purposes in a laboratory setting a magnetic tracking system (Polemus Inc.) was used to simulate tracked surgical tools. With this new software tool and the tracking system the exact relative location of a tracked instrument within all structures of the pelvic area, soft tissue as well as bone, could be displayed in 3D and real time without preprocessing of the data set. Until recently real time volume rendering required expensive workstations. With a new software tool on a four processor Pentium PC the authors were able to introduce a 3D real time processed data supply to the surgeon.

Fractures, Bone↗

Early biochemical characterization of soft-tissue trauma and fracture trauma.

OBJECTIVE: The long-term outcome of trauma patients basically depends on the relation between the clearance capacity of the organism, e.g., the lungs, and the antigenic (inflammatory) load in relation to the amount of damaged and perfused tissue. It is necessary to determine quality and quantity of fracture and soft-tissue damage by clinical means as early as possible. It is unknown whether biochemical markers and the impact of soft-tissue trauma correlate and whether there is a predictive value on clinical outcome. METHODS: A total of 107 trauma patients were prospectively enrolled in the study. Blood samples were collected immediately at the site of accident, at hospital admission, and every 2 hours for an interval of 24 hours, then daily. In addition to the biochemical analysis of 20 different substances, the following data were collected and correlated to the laboratory results: Injury Severity Score, polytrauma score of Hannover, modified fracture index, and soft-tissue index. These primary clinical findings as well as the laboratory data were correlated to criteria of clinical outcome such as length of stay in the intensive care unit, length of hospital stay, infections, systemic inflammatory response syndrome, sepsis, multiple organ failure score according to Goris, and finally to primary (< 72 hours), secondary (> 72 hours), and overall lethality. The determination of individual extent and severity of soft-tissue trauma is based on standard partial body volumes derived from healthy volunteers. In addition, clinical estimation of the degree of soft-tissue damage according to the usual classifications was performed. RESULTS: Significant (p > 0.05) correlations were found between fracture as well as soft-tissue trauma and intensive care unit stay, hospital stay, infections, systemic inflammatory response syndrome, multiple organ failure score, serum concentrations/activities of serum interleukin-6 and -8 and creatine kinase during the first 24 hours after trauma. Severe soft-tissue trauma was related to secondary lethality, however, without statistical significance. CONCLUSION: The amount of fracture and soft-tissue damage can be estimated early by analysis of serum interleukin-6 and creatine kinase and is of great importance with regard to long-term outcome after trauma.

Adolescent↗

[Prostanoid release and lipid peroxidation in patients with thoracic trauma].

UNLABELLED: There is compelling data from recent clinical studies on the impact of damage to the lung on the fate of traumatized patients. The lung reacts with a tremendous release of inflammatory mediators, but, on the other hand, this organ's ability in inactivating those factors is simultaneously attenuated. What is more, it is well known, that there often are no clinical signs of pulmonary dysfunction despite severe lung injury in the early posttraumatic phase. Therefore, in this prospective clinical study the following questions were addressed: (i) Is there any difference of the patients' lung response whether or not the (poly)trauma is associated with damage to the chest, (ii) either in the early or the late posttraumatic phase, and (iii) is there any marker that may prove to be a (significant) predictor of poor overall outcome? METHODS: Upon approval of the local IRB/EC, 35 patients (pts) were enrolled who suffered from multiple injuries. The first blood samples were drawn at admission, then every two hours and in daily intervals. The plasma concentrations of following mediators were analyzed: prostanoids (PGI2, TxA2, PGE2, PGF2 alpha) and products of O2-radicals (malondialdehyde, conjugated dienes). All values were calculated on the basis of the actual plasma protein content to eliminate fluid-induced dilution effects. Subsets of pts were performed according to the different injury pattern: (i) pre-dominantly thoracic trauma (TX, n = 9); (ii) polytrauma with (PTX, n = 19), and (iii) without (PT, n = 7) damage to the lung. RESULTS: As early as at admission, all pts revealed a severity-independent increase (p < 0.01) in most mediators' plasma levels. The pattern-related inflammatory response was most pronounced in casualties who had experienced thoracic trauma irrespective of whether it was combined with polytrauma. Within 1 to 3 days, the plasma levels of most mediators but PGE2 and MDA (all pts) as well as PGF2 alpha (PTX-group) normalized. The reactions of the lipid peroxidation products admitted of no group-differences. CONCLUSIONS: Although there was a pattern-related release of (most) prostanoids which was rather pronounced in polytrauma associated with damage to the lung, we failed in proving any predictive marker to specifically estimate outcome, so far.

Adolescent↗

[Prognostic importance of preclinically evaluated biochemical mediators in polytrauma].

UNLABELLED: There is compelling data from several clinical studies on the impact of various anti- and proinflammatory mediators on traumatized patients. Immediate trauma-related results, however, are only available from animal experiments so far. Therefore, in this prospective clinical study the following questions were addressed: (I) Is there any marker in the preclinical phase that give information independent of and better than conventional studies conducted so far, (II) does this possible factor prove to be a (significant) predictor of late complications and/or poor overall outcome, and (III) does this mediator provide information that can alter treatment decisions? METHODS: Upon approval of the local IRB/IEC, 85 patients (pts) were enrolled who suffered from multiple injuries. The pts were rescued by the helicopter-based service of the German Army Hospital in Ulm. The first blood samples were drawn at the site of accident and at admission, then in hourly to daily intervals. The plasma concentrations of following mediators were analyzed: Prostanoids, products of O2-radicals, soluble adhesion molecules, various cytokines, C-reactive protein, creatinine kinase, and neopterin. All values were calculated in relation to the actual plasma protein content to eliminate fluid-induced dilution effects. Subsets of patients were performed according to the severity of trauma (ISS < 9; 9-17; 18-31; > 32), based on the different injury pattern, and survivors versus nonsurvivors as well. RESULTS: As early as at the scene of accident, all patients revealed a severity-dependent increase in most mediators' plasma levels. There was, however, also a pattern-related inflammatory response that was most pronounced in pts who had suffered from thoracic trauma irrespective of whether it was associated with multiple trauma. In a total, 15 pts died within 72 h after the accident. In those casualties, the plasma concentrations of prostaglandin E2 (P < 0.03), glutathione (P < 0.01) as well as creatinine kinase (P < 0.05) were more markedly elevated when compared with survivors. CONCLUSION: Although there were severity-dependent as well as pattern-related releases of various mediators, which in part were more apparent in nonsurviving patients, we failed in proving any predictive marker to specifically discriminate outcome.

Accidents↗

Early posttraumatic increase in production of nitric oxide in humans.

Since nitric oxide (NO) contributes to both circulatory disorders and host defense, we analyzed the NO production in (poly)trauma patients (pts) in a prospective (pre)clinical study starting as early as at the scene of accident. Upon approval of the local IRB/EC, 85 multiple injured pts were enrolled. Subsets were performed according to trauma severity (ISS) and injury pattern, and between survivors versus nonsurvivors. The first blood sample was collected at the scene of accident, then in hourly to daily intervals. NO production was assessed by measuring nitrate+nitrite plasma levels. To estimate dilution effects, all values were calculated according to the actual plasma protein content. The extent of trauma was appraised by C-reactive protein (CRP) levels. Immediately after trauma, NO2-+NO3- plasma levels were always elevated. This was most pronounced in thoracic injury, irrespective of whether it was combined with multiple trauma. Nitrate+nitrite levels returned to normal within 24 h. CRP generation increased during 12 h following trauma and was most marked in severest trauma (ISS >50). For the first time, we show very early data following major trauma that demonstrate that NO overproduction starts immediately after trauma. However, systemic NO2-+NO3- levels actually reflect the severity of injury only during the first 2 h. Thereafter, NO generation is rather related to the individual trauma pattern, e.g., chest trauma. Nonetheless, the role of NO after severe trauma and especially in thoracic injury remains unclear and should further be elucidated in a specific study.

Adolescent↗

Transformation of Acinetobacter sp. strain BD413 by transgenic sugar beet DNA.

The ability of Acinetobacter sp. strain BD413(pFG4 delta nptII) to take up and integrate transgenic plant DNA based on homologous recombination was studied under optimized laboratory conditions. Restoration of nptII, resulting in kanamycin-resistant transformants, was observed with plasmid DNA, plant DNA, and homogenates carrying the gene nptII. Molecular analysis showed that some transformants not only restored the 317-bp deletion but also obtained additional DNA.

Acinetobacter↗

[Position of the German Society of Surgery in the community of scientific specialty societies].

The role of the German Surgical Society among the other scientific societies is considered as well as its relationship to the BAK and its scientific activities and publications compared with internal medicine. Its most important current issues are described and explained. It can be shown that it holds a prominent position, but is scientifically less productive than internal medicine.

General Surgery↗