Biomedical subjects

F Gay

Publications and source records attributed to F Gay.

130 records · Page 8Linked to original sources

PubMedDate not supplied

[Drug sensitivity of Plasmodium falciparum in vivo and in vitro in Brazzaville (Congo)].

Various projects were launched in 1993 to monitor the chemosensitivity of Plasmodium falciparum in Congo. Resistance of 34 strains in Brazzaville to chloroquine, quinine and mefloquine and of 35 to halofantrine was investigated in an in vitro survey using an isotopic micro test. The resistance rates were 61.8, 14.7, 3.0 and 0.0% respectively. Thus, the chemoresistance which first appeared in 1990 is confirmed and is stable in the population. This finding was further confirmed by a parallel in vitro analysis of sensitivity to chloroquine in Brazzaville. A chloroquine monitoring network is now being established throughout the country based on simplified WHO tests of 100 asymptomatic schoolchildren conducted every six months. The first results in 1993, from three Southern regions indicate that parasites are found in 20 to 60% of cases seven days after a standard 3 day treatment with 25 mg/kg, according to the region. The results of in vitro and in vivo tests are very variable. Indeed, the value of such results for these tests for national monitoring is questionable: a more reliable system of identifying true therapeutic failures would be better suited.

Animals↗

PubMedDate not supplied

[Evaluation of the QBC system for the diagnosis of malaria].

There are currently two methods for the direct diagnosis of malaria: the thin blood smear and the thick blood smear. A third cytological method, called the QBC malaria test (QBC), has been developed. The first studies comparing the three methods report conflicting results. Thus, there is a need for a study of the three methods in parallel and to evaluate the logistic factors which have not been previously assessed. In an analysis of imported malaria, one worker performed the three tests, blind, in parallel with each of 813 samples. The following values were determined: intrinsic validity; predictive values, species diagnostic power; and logistic factors. QBC had the following characteristics: sensitivity = 93.8%; specificity = 99.8%; positive predictive value = 99.3%; negative predictive value = 98.3%; correct species diagnosis = 91.3%; time required for test = 3.7 +/- 0.1 min; storage of tubes at +4 degrees C in the dark = 50 days; cost per test = 27.3 FF (as compared to 24 FF for thin smear and 17.3 FF for thick smear). Although unsuitable for use in countries where malaria is endemic, other than for some specialised situations, QBC is valuable for the diagnosis of imported malaria. In view of our findings, we suggest the following approach to diagnosis: use of the QBC and thin smear tests in parallel first reading the QBC result, as positivity contributes to reading the thin smear result for confirmation of species diagnosis and assessment of parasitaemia.

Acridine Orange↗

PubMedDate not supplied

Endoscopic varix ligation: a promising new technique?

Endoscopic varix ligation is a new promising endoscopic method which compete with endoscopic sclerotherapy both during acute bleeding and the chronic setting where the aim is to obliterate varices as soon as possible with minimal side effects.

Esophageal and Gastric Varices↗

PubMedDate not supplied

Adenocarcinoma of the ileum. A case report, and review of the literature.

A 47-year-old female presented with intestinal occlusion and a lower abdominal mass. On laparotomy, a 10 cm diameter mass was discovered involving the ileum, jejunum, vagina and the bladder. Pathological studies conclusion was a primary adenocarcinoma of the ileum involving the jejunum. Small bowel carcinoma is rare. It occurs between sixty- and seventy-year-old equally in male and female. It presents most frequently in the duodenum, sometimes in the jejunum, and occasionally in the ileum. The symptoms are not specific and do not point to the diagnosis which must be made radiologically and endoscopically. Currently, for a minority of patients, surgical resection remains the only hope of cure. Palliative resections and bypass procedures can prevent occlusion or subocclusion.

Adenocarcinoma↗