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Biomedical subjects

F Gardini

Publications and source records attributed to F Gardini.

35 records · Page 2Linked to original sources

[The new administration approach of the National Health System: implications for internal medicine. The point of view of the internist].

The laws for the reform of the Italian National Health Service (502, 517) show marked bureaucratic and administrative patterns. The aim of these laws seems to be mainly a tight control of the health expenses instead of an improvement of health care. This choice is confirmed by the selection of indicators (DRG's) more fit for reimbursement rather than for quality assurance in health care. Moreover, these indicators are only a poor expression of the real medical status of the patients. The reform of the British NHS appears very similar to the Italian reform, mainly for the empowerment of managers to detriment of health professionals and of health care quality. The reforms designed with the collaboration of health workers may be more useful than the reforms based mainly upon bureaucratic principles. Only with this collaboration the double target of the reduction of health related costs and of the maintenance of an acceptable quality may be achieved. The professional associations and the academic world must be involved in the political and organisational choices related with health care, mainly in the fields of the setting of organisational standards and of the training of actual and future doctors. The model proposed is that of internal medicine as an example of the ideal set of skills useful for a mixed clinical and organisational task. The internists, used to the solution of complex clinical problems, may be the ideal candidates for the role of clinical managers.

Delivery of Health Care↗

Neurotransmitter and endocrine modulation of aggressive behavior and its components in normal humans.

Correlations between aggressiveness and its components and plasma concentrations of norepinephrine (NE), epinephrine (EPI), testosterone (T), cortisol (Cort) and prolactin (Prl) were studied in 158 physically and psychologically healthy male volunteers. Global aggressiveness, examined directly in the probands by the Buss-Durkee Hostility Inventory (BDHI), was not correlated with any of the biochemical parameters investigated, but reports by first-degree relatives and spouses showed positive correlations between global aggressiveness and NE and T levels. The BDHI scores for 'irritability' and 'resentment' were positively correlated with NE, T and Cort.

Adolescent↗

Effects of growth conditions on the resistance of some pathogenic and spoilage species to high pressure homogenization.

The effects of chemico-physical growth conditions such as pH, temperature and water activity (aw) on lethal high homogenization pressure effects on Listeria monocytogenes, Staphylococcus aureus, Escherichia coli and Yarrowia lipolytica were investigated. The results, though based on standard media, emphasize the importance of food system composition and its thermal history on the high pressure tolerance of the microbial population.

Bacteria↗

Analysis of the interaction between autochthonous bacteria and packaging material in PVC-bottled mineral water.

A study with about 10,000 bottles produced by a mineral water company was undertaken in order to identify the causal agent of an off-odour occurrence in the bottled water. Some physiological attributes of the dominant species over an 8-month period, as well as their interaction with packaging material, were investigated. Pseudomonas maltophilia, P. acidovorans, Acinetobacter calcoaceticus var. lowffi, frequently associated with bottles having an off-odour, seemed to play a decisive role in the phenomenon due to their elevated lipolytic activity, their cell hydrophobicity and adhesivity to the PVC walls. Their ability to attack the sodium polysulfide included in the ultramarine blue dye present in PVC, transforming it to H2S was investigated.

Bacteria↗

Relationship between thermal behaviour, fermentation performance and fatty acid composition in two strains of Saccharomyces cerevisiae.

Two Saccharomyces cerevisiae strains, one specifically of S. cerevisiae and another belonging to the physiological race S. uvarum, exhibited associative and dissociate thermal profiles, respectively. The S. cerevisiae subsp. uvarum strain, which displayed the dissociative profile, was characterized by a higher aptitude for fermenting glucose in a superoptimal temperature range as well as by a lower fatty acid unsaturation degree. On the other hand, both strains exhibited a similar fatty acid composition modulation pattern with regard to temperature: the unsaturation level presented two relative maxima at 15 and 40 degrees C. However, on the basis of Central Composite Design results, supplementation with an oleic acid source under semi-anaerobic conditions did not improve the fermentative performances in either strain. The modelling of fermentation rate in relation to certain variables indicated that the fermentative performance at superoptimal temperatures, and particularly the optimal temperature (Topt) and maximal temperature (Tmax) of the strain displaying a dissociative profile, could be increased by acting on medium composition.

Biotechnology↗

Interaction between isolation source, cellular fatty acid composition and stress tolerance in Saccharomyces cerevisiae and its subspecies.

The physiological properties and fatty acid content of 59 strains of Saccharomyces cerevisiae isolated from soft-drink factories, a fruit puree factory, a fuel-alcohol distillery and a winery were compared. Discriminant analysis of the results allocated the strains to four groups according to their source. Resistance to preservatives and temperature stress were correlated with differences in fatty acid composition. The fatty acid C18: 1 delta 11, growth at pH 2 and in the presence of 200-600 mg l-1 benzoate or sorbate, and maximal growth rate at 42 degrees C were characteristics associated with yeasts from particular environments. However, tolerance of thermal stress and content of the C18: 2 fatty acid were associated with subspecies: the former species S. capensis, S. chevalieri, etc. The relative content of C10: 0, C12: 0 and C18: 0 acids varied according to both isolation source and subspecies.

Culture Media↗

Klebsiella pneumoniae as a spoilage organism in mozzarella cheese.

A high concentration of total and fecal coliforms (5 x 10(8) and 3 x 10(7) cfu/g, respectively) was observed in samples representative of two production lots of Mozzarella cheese from a local dairy. Contamination was manifested by the swelling of plastic pouches and the formation of gas holes in Mozzarella cheese. Aerobic and anaerobic sporeformers, heterofermentative lactic acid bacteria, propionibacteria, and yeasts were absent. Of the 41 isolates identified, there were 37 Klebsiella pneumoniae, 2 Klebsiella oxytoca, 1 Enterobacter aerogenes, and 1 Escherichia coli. Exposure at 63 degrees C for 15 min caused the death of all total and fecal coliforms.

Animals↗

Interactions between inhibition factors on microbial stability of fruit-based systems.

Measurement of metabolic CO2 by head space gas chromatography was used in the preparation of shelf-life maps of fruit-based systems. The systems analysed, all of which were peach-based, differed with respect to aw (0.995, 0.934 and 0.890), pH (3.02, 3.60 and 4.09) and benzoic acid concentration (0, 100 and 200 ppm). The test microorganism was a strain of Saccharomyces cerevisiae isolated from spoiled soft-drinks and chosen for its characteristic of multiple resistance. Three different thermal treatments were applied (54 degrees C for 15 min, 58 degrees C for 8 min, 63 degrees C for 3 min) to the systems and their effectiveness was evaluated in relation to the untreated controls. In contrast with observations for osmotolerant species, the relative preservative effectiveness on the test strain decreased with reducing aw and showed only a slight synergistic action with thermal treatment. Besides, the aw of the systems interacted synergistically with the thermal treatment effectiveness in a manner differing from that described for osmotolerant species.

Benzoates↗

Treatment of acute pain of ureteral and biliary colic with naproxen sodium administered by the parenteral route.

Non-steroidal, anti-inflammatory agents (NSAIDs), wellknown inhibitors of prostaglandins, have been used in the treatment of biliary and ureteral pain since the end of the 1970s. The efficacy and tolerance of a new injectable formulation of naproxen sodium in ureteral and biliary pain was investigated in 77 out-patients, observed in an emergency ward, and affected by acute lithiasic symptomatology. Forty-four patients received one 275 mg vial of naproxen sodium intramuscularly, while 33 patients were given one vial at the same dosage intravenously. In 56% of the cases complete relief of pain was achieved within 30 minutes of injection, while in 86% pain was completely relieved or greatly decreased within one hour. Side-effects (nausea, vomiting) occurred in three patients, but were linked to a simultaneous aggravation of the ureteral colic.

Adult↗

Short dialysis.

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Adolescent↗

Exostosis: development, evolution and relationship to malignant degeneration.

The authors report a study of 408 cases of exostosis (318 single and 90 multiple) from the records of the Tumour Centre of the Rizzoli Institute. Special attention was paid to the relationship with peripheral chondrosarcoma, 73 cases of which are also in the records of the Institute, and were separately studied. The authors conclude that it is impossible to determine the incidence of malignant transformation of solitary exostosis. The incidence of malignant transformation of multiple exostoses in the present case material was 13 per cent, but the true incidence would undoubtedly be higher if all patients were followed up for life.

Adolescent↗