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Biomedical subjects

F G Prior

Publications and source records attributed to F G Prior.

4 recordsLinked to original sources

Pulsing reverse osmosis as the mechanism underlying fluid exchange.

Problems inherent in the existing theories of fluid exchange are discussed. An alternative theory based on the interaction between the pulsing of the capillary pressure and the osmotic gradient between plasma and interstitial fluid is offered. Theoretic values for plasma and interstitial osmolalities are calculated. These are similar to the pressure found in the Bowman's capsule in the kidney. The theory offers a possible explanation for the pulsatile nature of the blood pressure, the formation of oedema and the stasis of fluid exchange in shock.

Animals

Theoretical involvement of vitamin B6 in tumour initiation.

Vitamin B6 is a co-enzyme involved in the biosynthesis of thymidine. Thymidine deficiency has been reported to increase DNA replication errors and hence increase mutagenesis. Carcinogenic stimulae increase the rate of DNA repair, and increase cell multiplication, both of which increase the requirement for thymidine. Vitamin B6 deficiency occurring at the same time as contact with carcinogens could well lead to tumour initiation and subsequent cancer development.

DNA