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Biomedical subjects

F Franchi

Publications and source records attributed to F Franchi.

At least 217 records · Page 12Linked to original sources
PubMed1976

Comparison of a natural heparinoid with sodium and calcium heparin for their effect on the inhibitor of activated factor X.

The reaction between activated factor X (Xa) and its natural inhibitor (XaI) was accelerated in vitro by both sodium heparin and an heparinoid, which was about 3 times less potent than heparin. The s. c. administration in humans of 5,000 units of sodium and calcium heparin was followed by the detection of a plasma activity potentiating XaI. In the majority of subjects, the heparinoid was not effective. These observations indicate that the use of heparinoids should not be considered as an alternative to heparin in the prevention of thromboembolism.

Adult↗
PubMed1976

Correction of abnormal coagulation in chronic liver disease by combined use of fresh-frozen plasma and prothrombin complex concentrates.

The effect on abnormal coagulation tests of infusions of fresh-frozen plasma (F.F.P), prothrombin complex concentrates, and a combination of these treatments was compared in 30 patients with chronic liver disease undergoing needle biopsy. A single dose of F.F.P. (12 ml/kg body-weight) was found to be the least effective therapeutic regimen. The concentrate containing factors II, IX, and X was also not adequate, but the additional administration of factor-VII concentrate corrected the prothrombin-time (P.T.) and "Normotest" (N.T.) in most patients. However, this regimen did not correct the prolonged kaolin activated partial thromboplastin-time (K.P.T.T.). The results of tests for exploring both the extrinsic (P.T. and N.T.) and intrinsic (K.P.T.T.) coagulation systems only became normal after the combined administration of a lower dose of F.F.P. (8 ml/kg body-weight) and of both concentrates (12 units/ml). There was no clinical or laboratory evidence of thrombotic complications. No patient developed acute hepatitis or hepatitis-B surface antigen in the twelve months after biopsy. These results indicate that prothrombin-complex concentrates in combination with F.F.P. may therefore be used to allow liver biopsy to be performed safely in patients presenting with severe coagulation defects.

Biopsy↗
PubMed1976

[Personal experiences of immunotherapy using the transfer factor].

Six subjects, four suffering from chronic mucocutaneous candidosis, one from ataxiatelangiectasia and one from partial combined immunological deficiency with ongoing pulmonary tuberculosis, were treated with transfer factor. The deficient immunological situation normalized in all subjects after treatment. Clinically, all showed improvement excepting one candidosis case.

Adolescent↗
PubMed1976

[An evaluation of right ventricular compliance (author's transl)].

Right ventricular "compliance" and "stiffness" in a casuistry of 51 patients were studied with varied pressure loads, using the "specific compliance" (SC) index proposed by Smith and coll. (1974) for the left ventricle and the "stiffness" constant proposed by Gaasch and coll. (1972, 1975). The pateints were subdivided according to a hemodynamic criterion, on the basis of telediastolic volume values (RVEDV) and telediastolic pressure (RVEDP) of the right ventricle. The average "specific compliance" was 0.1203 +/- 0.0283 in patients with RVEDP below or equal to 7 mmHg and 0.0517 +/- 0.0269 in those with RVEDP greater than 7 mmHg. In these two groups, the respective average values of the "stiffness" constant were 0.0136 +/- 0.0007 and 0.0210 +/- 0.0016. Comparison of the groups showed a significant statistical difference among the indices. In the subdivision into groups with telediastolic volume, the average SC values were respectively 0.0832 +/- 0.0083 in the patients with RVEDV below 150 ml/m2; 0.1131 +/- 0.0375 in the patients with RVEDV between 150 and 200 ml/m2; 0.0650 +/- 0.0132 in the patients with RVEDV above 200 ml/m2. None of the three groups demonstrated statistically significant differences. In the telediastolic volume groups, the average values of the "stiffness constant" were respectively: 0.0235 +/- 0.0020; 0.149 +/- 0.0007; 0.0117 +/- 0.0006. A comparison of the three groups showed statistically significant differences for this index. The authors consider that in pressure overloading of the right ventricle with different etiopathogenesis of "stiffness" and "compliance" indices, based on the measuring of volume and pressure, are unable to give absolute measuring of the physical characteristics of the ventricular walls. Thus, recourse to methods that can evaluate wall "stress" are necessary. However, the parametres considered are quite useful for indicating the variations of ventricular distensibility in homogenous casuistries and are therefore comparable.

Adult↗
PubMed1975

[Coronary cardiopathy].

Results obtained with selective coronariography, ventriculography, left catheterisation and the measurement of systolic times were compared in a series of 110 patients. Evaluation of vascular alterations with the aid of a coronary index showed that their entity was closely related to the incidence of asynergia and the extent to which left ventricular function was compromised. Index values were proportional to decrease of the DP/DT ratio, increased telediastolic pressure, lengthening of the pre-ejection phases and shortening of left ventricular systole. The physiopathological and clinical significance of these results is discussed.

Adult↗
PubMed1975

[Haemodynamic effects of nitroglycerin (author's transl)].

The haemodynamic effects of nitroglycerin (0.6 mg sublingual) have been studied in eleven patients with coronary artery disease, by means of the thermodilution method which enables cardiac output to be repeatedly measured at short time intervals (1-2 minutes). The following data have been studied: blood pressure (BP), pulmonary arterial pressure (PA), left ventricular filling pressure (LVFP), cardiac output (CO), stroke volume (SV), heart rate (HR), total systemic resistance (TSR), total pulmonary resistance (TPR), tension-time index (TTI) and left ventricular stroke work index (LVSWI). Within 1 minute following nitroglycerin (NG) administration the patients showed a decrease in TSR, TPR, and an increase in CO, SV, HR and LVCWI. TTI was reduced at the 5th minute. LVFP, PA and BP decreased after 3-5 minutes. CO increase at the 1st minute often compensated the fall in TSR, and blood pressure remained unchanged. The LVSWI/LVFP curve showed a transitory shift to the left at the 1st minute. In eleven normal subjects NG induced a minor increase in CO and SV, and a minor decrease in TSR at the 1st minute. The mechanism of action of NG in angina pectoris is briefly discussed.

Angina Pectoris↗