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Biomedical subjects

F Fodor

Publications and source records attributed to F Fodor.

At least 19 recordsLinked to original sources
PubMed1999

Deletion patterns of dystrophin gene in Hungarian patients with Duchenne/Becker muscular dystrophies.

Deletion pattern analysis of the dystrophin gene was performed in 159 Hungarian patients with Duchenne/Becker muscular dystrophy. In 116 cases (73% of total patients), exon deletions were detected by PCR amplification. In 37 patients (31.9% of patients with a deletion) one exon was deleted, while five or more exons were missing in 40 children (34.4%). With respect to the proximal-distal distribution of the deletions, 90 children (77.6%) had deletions exclusively at the 3' end of the gene, 21 deletions (18.1%) affected only the 5' end, and in five patients (4.3%) large-scale deletions were detected, which affected both regions. Analysis of the breakpoint distribution pattern in the dystrophin gene showed that, similarly to that observed in several Western European populations, intron 44 was involved most frequently (n = 35, 15.1%) as a starting breakpoint. In the Hungarian population introns 50 and 52 were the second (n = 30, 12.9%) and third (n = 29, 12.5%) most frequently observed hot spots at the 3' end; these seem to be characteristic for the Hungarian patients. At the 5' end the breakpoint peak (n = 6, 2.58%) was in intron two. As it was proposed by previous national studies, our findings also suggest that certain intronic sequences, characteristic for a population, probably determine the development of a preferential breakpoint profile in this disease.

Child↗
PubMed1999

[Difficulties in the treatment of secondary cataracts with the YAG-Nd laser].

The paper presents a clinical study performed about 402 patients with secondary cataract treated between 1989-1994 with YAG-Nd Laser capsulotomy in the University Eye Hospital from Tg. Mureş. We described the technique used, taking into consideration the recovery obtained, the early and belated complications and the secondary effects.

Adolescent↗
PubMed1998

Absence of 185delAG mutation of the BRCA1 gene and 6174delT mutation of the BRCA2 gene in Ashkenazi Jewish men with prostate cancer.

Epidemiological studies have demonstrated a clustering of breast and prostate cancers in some families. Moreover, there is an increase in the number of cases of prostate cancer in families with inherited mutations of the breast cancer susceptibility gene BRCA1. We assessed the role of BRCA1 and BRCA2 in prostate cancer. We tested for the BRCA1 185delAG frameshift mutation, found in 0.9% of Ashkenazi Jews, and the BRCA2 6174delT mutation, found in 1% of Ashkenazi Jews, in Ashkenazi Jewish men with prostate cancer. We studied 60 Ashkenazi men with prostate cancer. A family history was obtained by interview or a self-report questionnaire. Histological confirmation of diagnosis was obtained for all subjects. Ethnic background was confirmed for all subjects by self-report or interview. Mutations of BRCA1 and BRCA2 were detected by amplification of lymphocyte DNA from peripheral blood according to standard polymerase chain reaction (PCR) and dot blot procedures. Patients' ages ranged from 55 to 80 years (mean +/- s.d. 70 +/- 5.25). There were six men with a family history of prostate cancer; three of these had a father with prostate cancer. Five of the men had a family history of breast cancer, in a mother, a sister or an aunt. None of the men had a family history of both breast and prostate cancer. None of the 60 men carried the 185delAG BRCA1 or 6174delT BRCA2 mutations. Of 268 Ashkenazi Jewish women with sporadic breast cancer, tested in an unrelated study, 16 carried either the 185delAG mutation of BRCA1 or the 6174delT mutation of BRCA2. There was a significant difference in the incidence of the BRCA1 and BRCA2 mutations in the breast and prostate cancer cases (P = 0.05, two-tailed Fisher's exact test). The contribution of germline BRCA1 and BRCA2 mutations to prostate cancer incidence is probably small and could be limited to specific subgroups.

Aged↗
PubMed1994

[Fetal and neonatal endocarditis].

Two infants with endocarditis were diagnosed at our Institute within a six month period. One infant died due to severe aortic valve destruction and ruptured sinus Valsalvae aneurysm both of which developed during fetal life. The other one with tricuspid valve endocarditis was successfully treated after the early echocardiographic diagnosis. To our knowledge this patient is the only survivor with neonatal endocarditis in our country.

Endocarditis, Bacterial↗
PubMed1990

Increased density of histiocytes in uterine leiomyomas.

The histiocyte content of leiomyomata and adjacent, histologically normal myometrium has been quantified morphometrically with the help of recently developed immunostaining for tissue macrophages. Histiocytes identified by immunoreaction for Factor XII subunit A and by double immunofluorescent labelings were found to be identical with tissue macrophages present in normal uteri. Histiocyte counts were significantly higher in leiomyomatous areas than in adjacent normal myometrium, and the distribution of these cells was also changed. In the normal uterine wall, histiocytes could be detected only in the connective tissue septa separating smooth muscle bundles, while in the myomatous nodules they were diffusely scattered throughout the whole area. In addition to providing new information on the cellular composition of leiomyomas, the present observations also raise several questions concerning the possible pathogenetic role of FXIII-positive histiocytes in neoplastic proliferation of uterine smooth muscle.

Factor XIII↗
PubMed1983

Pharmacokinetics of a sustained-release trimazosin tablet formulation.

Pharmacokinetics and bioavailability of a trimazosin sustained-release tablet (SRT) formulation (300 mg) were studied in healthy volunteers. In the first study of 12 subjects, the bioequivalence of trimazosin, 100 mg, in a standard tablet (ST) and in a capsule was demonstrated. After that, the bioavailability of one SRT (300 mg) was compared with that of the STs, (100 mg three times a day), in 19 subjects. Maximum plasma concentration (Cmax) after SRT (8.1 +/- 3.0 mg/L) was significantly lower than that observed after ST (13.5 +/- 2.3 mg/L), time to peak was strongly delayed by a factor 7, and the time when plasma concentrations were higher than half of Cmax (t Cmax/2) was longer (10.4 +/- 3.2 vs 2.3 +/- 0.6 hours, p less than 0.001). Bioavailability of the SRT (300 mg) as measured by the area under the curve (AUC00) was about 65% of the ST. At the seventh dose, after single daily doses of the SRT in 12 subjects, the mean Cmax values were not significantly higher than after the first dose (8.6 +/- 3.2 mg/L vs 7.7 +/- 2.2 mg/L), t Cmax/2 values were the same (10.4 hours), and the AUC0-24 hr was comparable to AUC00 calculated after the first dose. Steady-state plasma concentration of trimazosin was obtained rapidly. No accumulation of trimazosin or its metabolite occurred.

Adolescent↗
PubMed1982

[Pharmacokinetics of theophylline and circadian rhythm].

In the purpose to evaluate the circadian changes of theophylline pharmacokinetic, 8 healthy subjects (age range 22-39 y, weight 54-91 kg) were given a single oral dose of 4,5 mg/kg theophylline solution. Administration was made randomly at 9 a.m. after 12 hours fasting and at 9 p.m. After evening administration the subjects remained awake during the night and a standardized meal was served 4 h and 9 h after theophylline intake. Plasma theophylline concentrations were measured by a high performance liquid chromatography. Absorption is significantly faster in the morning than in the evening but C max values were identical. Plasma elimination half-life is significantly different (8,01 +/- 1,95 h in the morning, 6,23 +/- 1,75 h in the evening). No significant modifications were observed of the area under the curve, the body clearance, the apparent volume of distribution. There were no differences in the total body clearance, the area under the concentration-time curve, the apparent volume of distribution.

Adult↗
PubMed1981

[The effect of the synthetic detergents on the formazan formation of various environmental bacteria (author's transl)].

The authors studied the changes in activity of the dehydrogenase enzyme purifier of in the hygiene important bacteria, caused by different concentrations of various detergents with the aid of the triphenyl-tetrazolium chloride test (TTC) (Simmons-Williams test). The cation-active CTAB, in a contentration of only -0.008%, inhibited the enzymatic activity in all bacteria tested, whereas the non-ionic detergents (Praewozell and G 3707), even in high concentrations (5%) produced no inhibiting effect. The anion-active detergents (DBSNa-LSNa) differed in their action on the test bacteria, but Str. faecalis appears to be the most sensitive species, but Micrococcus was also sensitive. In the case of Str. faecalis a 0.03% DBSNa concentration and a 0.008% LSNa concentration was needed to produce the same effect in micrococci. E. coli pathogens proved relatively resistant to anionic detergents; a complete inhibition of the enzymatic activity was brought about by a 1% DBSNa and 0.63% LSNa concentrations. The results suggest that the TTC testing method is suitable for the evaluation of the action of ionic detergents in the organism.

Bacteria↗
PubMed1976

[The action of detergents upon microbes (author's transl)].

The effect of sodium dodecyl benzene sulphonate in the concentration range of 0.125%-1.0% upon gas formation by Klebsiella and Escherichia was studied. The experiments were performed in Szántha's gas tubes on synthetic culture media containing glycerol; gas formation was measured volumetrically. Concentrations below 1.0% were found to promote gas formation when compared with the control tubes. In accordance with previous papers published, enteric and chromogenic bacteria also multiplied well in the presence of 1.0% DBS-Na. It is shown by the results at hand that additional studies of the influence of detergents upon processes of self-purification in surface waters should be performed.

Benzenesulfonates↗
PubMed1975

[Heterotopic corneal transplantation in the treatment of conjuctival sac insufficience (author's transl)].

To reform the conjunctival sac in cases of symblepharon or when the globe is not present, various procedures and materials are used. The cornea showed itself to be suitable material for covering areas which are left naked after removing corneal adhesions. Heterotopic corneal transplantation leads to good results in the treatment of clinical and thermic burns and also in insufficience of the conjunctival sac in cases of anophthalmia. The procedure allows the simultaneous transplantation of several corneae. The operation can be repeated when necessary. The author has applied this procedure in eight cases with good results.

Conjunctiva↗