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Biomedical subjects

F Figueroa

Publications and source records attributed to F Figueroa.

At least 127 records · Page 7Linked to original sources
PubMed1983

Crossreactivity between Qa-1 region and H-2K antigens.

Antiserum (A.TL X A.SW)F1 anti-A.TH is specific for the products of the Qa-1a region. It reacts only weakly or, under certain circumstances, not at all with the immunizing cells, but it reacts strongly with 100% of H-2f and H-2p lymphocytes. The molecules that are the target of this strong heteroclitic reactivity are controlled by a gene in the K region, most likely the K locus itself. The results are interpreted in terms of crossreactivity of Qa-1-specific antibodies with Class I major histocompatibility complex molecules. This crossreactivity underscores the relatedness of Qa and Class I loci and strengthens the argument that Qa loci are members of the Class I family.

Animals↗
PubMed1983

H-2 haplotypes carrying identical D but different L alleles.

The B10.SAA48 congenic line was derived by transferring the H-2 haplotype of a wild mouse onto the background of the inbred strain C57BL/10Sn (abbreviated as B10). The line carries the Dw3 allele in combination with an L allele different from that present in other Dw3 strains. One possible explanation of this finding is that crossing over occurred between the D and L loci. The determinants H-2.m64 and H-2.m65 represent an inclusion doublet in which the latter never occurs without the former. Typing of B10.W lines with Ld-specific CTLs reveals the absence of this allele in all the lines, including those carrying an allele serologically similar to Ld.

Alleles↗
PubMed1983

Polymorphism of Qa and Tla loci of the mouse.

Congenic lines carrying H-2 haplotypes derived from wild mice were typed serologically with polyclonal and monoclonal antibodies specific for Tla, Qa-1, and Qa-2 antigens. The typing revealed the presence of a minimum of five Tla, four Qa-1, and three Qa-2 alleles in the 32 lines. Two new Tla, two new Qa-1, and one new Qa-2 alleles could be described. This polymorphism of Tla and Qa loci is lower than that detected at the K and D loci in the same lines. The serological typing for Qa-2 antigens correlates remarkably well with previously published results of typing with cytolytic T lymphocytes. This correlation supports the identify of loci detected by the two methods.

Animals↗
PubMed1982

The minimal length of the differential segment in H-2 congenic lines.

One hundred and four H-2 congenic lines were typed for alleles at seven loci, Qa-1, Qa-2, Tla, C3, Ce-2, Pgk-2, and Upg-1, residing distal to the H-2 complex. The results of the typing were used to estimate the length of the segment of chromosome 17 derived from the donor strain of each line--that is, the minimal length of the differential segment. The results indicate that only lines derived by intra-H-2 crossing-over in such a way that they inherited the right-hand portion of H-2 from the inbred partner have the telomeric half of chromosome 17 identical with that of the inbred-partner strain. In other lines the differential segment is at least 3 to 10 cM long. It is argued that in some lines the entire telomeric half of chromosome 17 might be of donor-strain origin.

Animals↗
PubMed1982

Evidence for placing the Neu-1 locus within the mouse H-2 complex.

Congenic lines B10.KPA42, B10.KPA132, B10.SNA57, B10.DRB62, and B10.WOA105 carry H-2 haplotypes of wild mice on the genetic background of the strain C57BL/10Sn. Two of the lines (B10.DRB62 and B10.WOA105) have H-2 haplotypes indistinguishable from H-2v of B10.SM. The H-2 haplotype of one line (B10.SNA57) seems to have arisen from H-2v by recombination between the D and Qa-2 loci. The H-2 haplotypes of the remaining two lines probably arose from H-2v by recombination between the C4 and D loci. Since all six and no other lines carry the rare Neu-1a allele, the neuraminidase-1 locus is probably located proximal to the H-2D locus. Typing of H-2s recombinants for the enzyme acid phosphatase liver, the processing of which is controlled by the Neu-1 locus, suggests that the locus resides between the E alpha and D loci, that is in the S region.

Acid Phosphatase↗
PubMed1981

H-2 antigen frequencies among wild mice from Chile.

Thirty-five wild mice (Mus musculus L.) were captured at four different localities in Chile. The mice were typed for the presence of 15 K-, 11 D-, 14 A-, and two E-region H-2 antigens, using the complement-antibody microcytotoxicity assay. The mice from the sample representing the largest locality had a characteristic antigenic profile distinguishing them from other mouse populations thus far studied. With respect to class I H-2 antigens, the profile was characterized by the presence of antigens H-2K.16, 31, 103, 19, 108, 21, 33, 26, 115, and H-2D.4, 106, 30, 32, 111, 114, and 18 (in order of decreasing antigen frequency), and by the absence of antigens H-2K.15, 17, 20, 113, 116 and H-2D.2, 9, 110, and 112. The profile was, furthermore, characterized by the relatively high frequency of antigens H-2K.16, 31, and H-2D.4 and 106. The profile of class II antigens was also unique to the Chilean population but less conspicuously so than that of the class I antigens. Analysis of antigenic associations suggested that among the 34% blank H-2K alleles there were at least two coding for relatively frequent but as yet unidentified K antigens. Similarly, among the 57% blanks at the H-2D locus there were at least two frequent alleles encoding unidentified D antigens. Analysis of genetic distances suggested similarity between South American mice and mice from coastal regions of Europe.

Alleles↗