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F Ferrozzi

Publications and source records attributed to F Ferrozzi.

106 records · Page 6Linked to original sources
PubMedDate not supplied

Mesenchymal tumors of the pancreas: CT findings.

This article reviews the CT imaging features of the most frequent mesenchymal tumors of the pancreas and stresses important distinctive patterns that may help distinguish specific entities. Various neoplasms (lymphangioma, lipoma, teratoma, pancreatoblastoma, schwannoma, neurofibroma, lymphoma, and sarcoma) are reviewed, with key differential points (structure, fatty and water densities, calcification, pattern of contrast enhancement, vascularization, and necrotic or regressive changes) emphasized. In addition, epithelial tumors are considered in the differential diagnosis.

Adolescent↗
PubMedDate not supplied

Lipomatous tumors of the stomach: CT findings and differential diagnosis.

This article reviews the computed tomography imaging features of a variety of gastric tumors containing fatty tissue. Lipoma, angiolipoma, liposarcoma, and teratoma are described. Differential diagnosis includes primary and reactive lipomatosis, carcinoma engulfing the perivisceral fat thus mimicking differentiated liposarcoma, and mesenchymal gastric and peritoneal neoplasms.

Adult↗
PubMedDate not supplied

[Gastric stromal tumors. Findings with computerized tomography].

PURPOSE: Gastric stromal tumors are an ill-defined group of lesions arising from muscle wall cells and characterized by extremely variable biological patterns. Thanks to modern immunohistochemical and ultrastructural techniques, four main classes of these lesions have been identified, namely: 1) tumors with differentiation toward smooth muscle cells; 2) tumors with differentiation toward neural elements; 3) tumors with dual differentiation toward both cell types; 4) tumors lacking differentiation toward either cell type. We investigated the yield of CT in diagnosing and characterizing gastric stromal tumors. MATERIAL AND METHODS: We retrospectively reviewed the CT findings of 38 patients (15 men and 23 women; mean age 51 years) with pathologically proven gastric stromal tumors, namely 31 of myoid origin, 4 of neural origin, 2 with both muscle and neural differentiation, 1 lacking differentiation with either cell type. Morphological (size, margins, growth pattern, enlarged lymph nodes, metastases) and structural (density, calcifications, necrosis, cystic changes, enhancement patterns) parameters were evaluated and compared with histopathologic diagnosis. RESULTS: The myoid tumors involved gastric fundus in 9/13 and 5/7 benign lesions and lesions with variable biological patterns, respectively, while the malignant tumors exhibited diffuse involvement in 7/11 of cases. Eleven of 13 benign lesions had regular shape and a diameter +/- 5 cm, while 5/7 intermediate tumors and 7/11 malignant ones were 6-10 cm and over 10 cm (1/7 and 3/11, respectively). Tumor growth was intramural (6/13) or mixed (5/13) in the benign lesions, mainly exophytic in the malignant ones, and finally variable (2/7 intramural, 3/7 exophytic and 2/7 mixed) in the tumors with intermediate patterns. Calcifications were identified only in 3 benign lesions. Structure was homogeneous in 11/13 of the benign lesions with regular contrast enhancement (10/12), heterogeneous due to necrotic areas in nearly all (10/11) or most (5/7) malignant and intermediate forms, respectively. Enlarged lymph nodes (4/11) or synchronous metastases (7/11) were found in the malignant lesions. Our two schwannomas had a pseudocystic structure with regular peripheral contrast enhancement; the neurofibroma was characterized by multiple, markedly hypodense and hypovascular lesions. Both the malignant neurogen form and the two tumors with dual differentiation showed a diffuse, aspecific and infiltrating pattern. The lesion without differentiation had a "benign" shape and structure even though it developed metastases two years after radical surgery. CONCLUSIONS: Despite the lack of specificity of CT patterns of gastric stromal tumors, these parameters are useful in differentiating benign from overtly malignant forms. The definition "gastric stromal tumor with benign, variable, or malignant macroscopic appearance" should be used in the radiologic report.

Adult↗
PubMedDate not supplied

[A magnetic resonance study of 39 children with different causes of short stature].

PURPOSE: To investigate the relationship between Magnetic Resonance (MR) findings and the presence of isolated growth hormone deficiency (IGHD) or multiple pituitary hormone deficiency (MPHD). MATERIAL AND METHODS: 39 children, 27 boys and 12 girls (mean age 9.6 years) were enrolled. The growth hormone deficiency and MPHD were defined by standard laboratory methods. MR scans of the hypothalamo-hypophyseal tract were carried out on all patients before the therapy. Perinatal histories were reviewed. RESULTS: The pituitary anterior lobe was considered small in 13/39 (33%). Twenty-six of 39 (66%) patients did not show any abnormalities of the hypothalamohypophyseal tract. An ectopic neurohypophysis was found in 8/39 patients (20%). Only 2 patients among those with an ectopic neurohypophysis showed a small anterior pituitary lobe. Thirty-three of 39 (84.6%) patients showed IGHD while 6/39 (15.4%) patients showed MPHD. Twenty-eight of 39 (71%) patients had a severe deficiency while 11/39 (28%) patients had a moderate deficiency. CONCLUSION: Our study confirms the usefulness of MRI in the diagnostic and therapeutic approach to short stature in children; in fact 48% of patients in our series showed MR findings reasonably related to hormonal deficiency.

Adolescent↗
PubMedDate not supplied

[Idiopathic retroperitoneal fibrosis].

Retroperitoneal fibrosis is an uncommon disease, characterized by the replacement of normal retroperitoneal tissue with fibrosis and/or chronic inflammation. In two thirds of the cases retroperitoneal fibrosis is idiopathic (IRF), whereas in the remaining ones it is secondary/associated to cancer, infections, drugs, autoimmune disease and vasculitis. IRF appears as a dense, fibrous plaque that usually arises between the level of the lower aorta and the common iliac arteries. As the plaque progresses, it engulfs the adjacent structures (e. g., ureters). In its early stages IRF is characterized by a rich infiltrate of lymphocytes, plasma cells and macrophages interspersed within fibroblasts and collagen bundles. In its advanced stages it becomes relatively avascular and acellular with abundant collagen bundles and scattered calcifications. The pathogenesis is unknown: some Authors suggest that IRF is a consequence of a local autoimmune reaction against atherosclerotic plaque antigens whereas others propose that it is the manifestation of a systemic autoimmune disease. The presenting signs and symptoms are non-specific; systemic manifestations (fever, anorexia, weight loss), often associated with local symptoms, are usually found to be related to the entrapment of retroperitoneal structures. The most common local symptom is lumbar and/or abdominal pain. The treatment can be surgical and/or medical: the former is required when obstructive complications are present; the latter, associated or not with surgery, can significantly improve the outcome of IRF patients and usually modifies the natural history of the disease. Steroids and tamoxifen are the most used drugs, whereas other agents such as azathioprine, methotrexate and cyclosporine are usually given to non-responder patients.

Humans↗
PubMedDate not supplied

[Echotomography-computerized tomography integration in the tissue characterization of renal angiomyolipoma].

A sonographic and a computed tomographic study of 29 patients was performed in order to assess the possibilities of these imaging techniques in tissue characterization of renal angiomyolipoma. From the review of the results the authors, confirming the very high accuracy of the two associated methods for a correct diagnosis, underline the possibility to identify the hamartoma mesenchymal components with the possibility of more prognostic and therapeutic informations.

Female↗
PubMedDate not supplied

[Pulmonary iatrogenic lesions in chemotherapy: computerized tomography findings].

PURPOSE: To analyze the lung damage caused by anticancer drug toxicity comparing the pathologic mechanisms, histopathologic response and CT features. MATERIAL AND METHODS: Twenty-one patients (15 men and 6 women aged 21-75 years, mean: 41) were selected from the cancer patients treated with chemotherapy 1990 to 1997 (1400 lung examinations in all). The primary tumors consisted of: 6 testicular, 2 ovarian, 2 breast and 1 renal cancers; 3 non-Hodgkin lymphomas; 1 acute myeloid and 1 chronic lymphatic leukemia; 1 melanoma, 1 uterine leiomyosarcoma, 1 liposarcoma, 1 osteosarcoma and 1 head and neck carcinoma. All the patients underwent a CT examination with contiguous 8-10 mm slices and thin (4-5 mm) detail slices or with the high resolution technique. All the cases had clinical, laboratory and pathologic confirmation of the drug-related lung damage. RESULTS: Four alveolar opacities, 11 interstitial opacities, 2 solitary and 4 multiple nodular lesions were demonstrated. Bleomycin was the most toxic drug in 14/21 cases, the total dose always exceeding 450 mg. Methotrexate followed and then cytosine-arabinoside (both 2/21). Bleomycin was responsible for all nodular lesions, cytosine-arabinoside and interleukin-2 for pulmonary edema. After drug discontinuation and appropriate treatment in 14 cases, we found favourable evolution with restitutio ad integrum (9 cases) or CT findings of clear improvement (5 cases); fibrosis progressed in 6 cases and one patient died. CONCLUSIONS: CT provides important information for the diagnosis of drug-induced lung damage. Despite the nonspecific patterns of the lesions, CT can demonstrate the early, and thus potentially reversible, stages of lung damage. CT is also very helpful in monitoring the onset, resolution, or progression of fibrosis.

Adult↗