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Biomedical subjects

F Ferrozzi

Publications and source records attributed to F Ferrozzi.

At least 73 records · Page 4Linked to original sources

[AIDS-related neoplasms: a clinico-radiological study].

Although high-grade non-Hodgkin's lymphoma (NHL) and an unusually aggressive form of Kaposi's sarcoma (KS) remain the most common malignancies seen in AIDS patients, other tumors such as cervical cancer, Hodgkin's disease and others, have been increasingly observed, probably because these patients now live longer. We report the imaging findings of 80 AIDS patients with pathologically confirmed neoplasms from a series of 340 AIDS patients examined 1986-1994. Twenty-four of 80 patients had NHL, 4 Hodgkin's disease, 31 KS, 4 cervical cancer, 2 leukemia, 2 testicular, 1 larynx, 2 lung, 2 breast, 1 esophagus, 1 stomach, 1 liver, 2 kidney and 3 adrenal carcinomas. Twenty of 24 NHLs exhibited extranodal involvement--to the liver (13/24), brain (9/24), lung (7/24) and gastrointestinal tract (6/24). Visceral KS involved the gastrointestinal tract (6/32), lung (4/32) and liver (2/32). The most accredited pathogenetic theories concerning the role of HIV infection in oncogenesis advocate the effect of multiple growth factors produced by HIV-infected lymphocytes (KS) or the disregulation of B-cells caused by T-cell destruction (NHL). The atypical morphostructural features of AIDS-related tumors are discussed--e.g., atypical presentation, occurrence in younger individuals, aggressive clinical course and poor response to conventional therapy--together with the differential diagnostic problems, especially vs. opportunistic infections.

Acquired Immunodeficiency Syndrome↗

[Venous leakage impotence: anatomical and physiological considerations upon gravity cavernosometry and radio-fluorographic cavernosography].

We performed gravity cavernosometry and radio-fluoro-graphic cavernosography with pharmacological intracavernous injection in 15 patients with erectile dysfunction. On the basis of cavernosographyc findings, in the 15 patients leak sites visualized included deep dorsal vein in all 15 patients leak sites visualized included deep dorsal vein in all 15 patients (100%), cavernous veins in 7 (46,6%), glans in 4 (26,6%) and corpus spongiosum in 3 (20%). Aberrant veins documented in 4 patients (26,6%): communicating with the saphenous vein in 2 (13,3%), with scrotal veins and femoral vein in 1 (6,6%). Deep dorsal vein leakage as the only venous site was find in 2 patients (13.3%), 9 (60%) had leakage through 2 venous sites, 3 (20%) had leakage through 3 venous sites and 1 (6,6%) had leakage through 4 venous sites. Correlations among hemodynamic and radiographic observations allowed the identification of 2 types of cavernosometric findings. While type I developed an high intracavernous pressure during gravity infusion, an high intracavernous pressure was not observed in type 2. The FCG by the digital radio-fluoro-graphic digital system permit the possibility of sottraction and rielaboration of images and reduces examination and radiation time. The gravity FCM is simple, not expensive and respect the physiological intracavernous pressure.

Adult↗

Gastric liposarcoma: CT appearance.

Two cases of liposarcoma of the stomach are described. At computed tomography (CT) the neoplasms showed features of an aggressive malignant tumor, with no fatty values within. We discuss the differential diagnosis of such lesions and conclude that, although rare, liposarcoma should be considered as a possible diagnosis when a large exophytic gastric mass is detected at CT.

Diagnosis, Differential↗

[Direct radiographic enlargement in mammography in everyday practice. Indications and limitations].

One thousand mammograms of non-preselected patients were reviewed in order to assess in how many and which cases an equivocal diagnosis can be made unquestionable and to test the value of follow-up exams with direct radiographic magnification. Direct radiographic magnification was used in all questionable cases (3%): 18 lesions were characterized by microcalcifications and 12 by nodules. Four cases were diagnosed as unquestionable (13%)-1 microcalcification and 3 nodules-while 13 patients were reexamined with mammography only. Even though the percentage variation from equivocal to unquestionable diagnoses is modest but significant, direct radiographic magnification is always useful in the follow-up.

Adult↗

[Hemosiderosis in thalassemia major. Quantitative study with magnetic resonance (MR)].

Hemosiderosis, which results from transfusional therapy and from increased absorption of dietary iron, is a severe complication of thalassemia major. The complication is also very difficult to manage. An accurate determination of the total amount and of the distribution of body iron stores is essential for prognostic purposes and to evaluate the efficacy of chelation therapy. Therefore, a suitable tool for the noninvasive depiction of iron overload is to be hoped for. MR imaging has been usefully employed, of late, to this purpose. Sixteen thalassemic patients have been studied to evaluate iron depositions using a 1.5 T magnet. Signal intensities from liver, pancreas, spleen, bone marrow, and heart were considered. The signals were dramatically lower than the normal values obtained in a sex- and age-matched group; the differences were due to the iron. Iron distribution appeared inhomogeneous, with the highest overload in liver and bone marrow. Since cardiomyopathy represents the first cause of death in thalassemic patients, the relationship between cardiac function and iron overload in the heart has been thoroughly investigated. Finally, the authors conclude that MR will become a widely employed method for assessing iron overload and will contribute to improve the management of thalassemia major.

Adolescent↗

[X-ray computed tomographic aspects of calcifying metastases. Apropos of 40 cases].

The authors report the results of a study on 40 patients affected by metastases of the calcifying type detected during CT scan imaging for cancer of different origin (colorectum 18 cases, stomach 5, ovary 10, lung 2, bone 2, breast, skin, thyroid 1 case). The sites involved include liver (22), spleen (5), lymph nodes (10), peritoneum (7), diaphragm (2), pleura (2), ovary (1), soft tissue (3), lung (3). Calcification in metastases arises through a double mechanism: primary, with bone formation in osteoid neoplasia (orthoplastic calcification) or ossification of tumour cartilage (metaplastic calcification); secondary as a result of necrosis, hemorrhage and regressive changes (dystrophic and mucoid calcification), particularly after radiation or systemic treatment. Since calcified metastases can strongly mimic granulomatous, parasitic and other neoplastic disease, the clinical history is essential for the diagnosis.

Calcinosis↗

[Pancreatic cystic neoplasms. Echographic-CT aspects and differential diagnosis].

Cystic neoplasms of the pancreas are rare lesions. Following the Compagno-Oertel classification, we differentiated serous microcystic adenomas (SMA) from mucinous macrocystic adenomas/adenocarcinomas (MMA). The former are benign tumors with slow growth, composed by innumerable small and tiny cysts with central calcifications, resulting in a "honeycomb" pattern. They have a mixed US structure while CT densitometric values reflect a mixture of connective tissue and proteinaceous fluid. Postcontrast enhancement is frequently seen. MMA are potential (adenoma) or frankly (adenocarcinoma) malignant tumors. They appear as multilocular cystic masses containing septa and/or papillary bulges, with thickened walls. Both US and CT demonstrate their predominantly cystic character, and the eventual presence of excrescences. We report a series of 23 cases (6 SMA, 17 MMA) of cystic neoplasms of the pancreas studied during the past five years. A correct diagnosis of SMA was possible in all 6 cases, while MMA was correctly diagnosed in 17 out of 18 cases. There were no false negatives, and 1 false positive. All differential diagnoses are also discussed.

Adenocarcinoma, Mucinous↗

[Milk of calcium renal lithiasis: uro-echographic evaluation].

From the fortuitous observation of a rare case of "milk of calcium" lithiasis in a renal calyceal diverticulum, the authors, having examined the etiopathogenetic implications of the disease and having considered the problems of differential diagnosis, discuss whether urography and sonography are a valid means of making a correct diagnosis and the consequent implications of a therapeutic nature which this pathology would involve.

Aged↗

[CT in the evaluation of the extension of bronchogenic carcinoma].

The computed tomographic patterns in 52 patients with histologically proven lung cancer are reported. The AA. underline the not sobstitutive role of C.T. scan in pre-operative determination of bronchogenic carcinoma extension. C.T. revealed a very high diagnostic accuracy in assessing the primary tumor extension and in evaluating distant macrometastases; however, in showing hilar and mediastinal nodal involvement has not the same accuracy. The AA. think that, at the present time, a combinate C.T. study of the chest, upper abdomen and brain is, in the most number of cases, a rapid, accurate and practical method to evaluate the extension of lung cancer.

Adrenal Gland Neoplasms↗

Gastric metastases from retroperitoneal leiomyosarcoma.

Computed tomographic (CT) appearance of two cases of gastric metastases from retroperitoneal leiomyosarcoma are reported. In both cases tumors infiltrated the gastric wall with endoluminal growth. The use of water-filling technique in opacifying the lumen and distending the gastric wall is also emphasized.

Female↗

CT and MR demonstration of fat within an adrenal cortical carcinoma.

Detection of fat within an adrenal primary mass is virtually pathognomonic of myelolipoma, and in most cases such a diagnosis excludes any further diagnostic and therapeutic approaches. We report our findings, with computed tomography (CT) and magnetic resonance (MR), of the first, to our knowledge, pathologically proven case of fat tissue within an adrenal cortical carcinoma. We also discuss the possible origin of fat within such malignancies and the potential diagnostic dilemmas it might cause.

Adipose Tissue↗