Biomedical subjects

F Ferri

Publications and source records attributed to F Ferri.

77 records · Page 5Linked to original sources

PubMedDate not supplied

Systemic lupus erythematosus and renal involvement: which role of citokines expression?

The role of cytokines in systemic lupus erythematosus (SLE) glomerulonephritis is extremely complex. Proinflammatory molecules, such as TNF, IL-6, IL-1 and IL-18 are upregulated, as are both Thl and Th2 cytokines, with different implications: the local effects may be different from the systemic immunoregulatory ones. Excessive T helper cell function is a hallmark of SLE and abnormalities of Th citokine profiles have been implicated in loss of immune tolerance, increased antogenic load, defective B cell suppression and a variety of clinical manifestations. For some cytokines, TNF and IL-18 in particular, the local proinflammatory ones may be more relevant to the disease.

Cytokines↗

PubMedDate not supplied

[Possible cost reduction and better surgical results using EEA stapler in tumors of the upper rectum].

The aim of this work was to compare the relative costs and outcome of the anterior resection of the rectum for upper rectal cancer mechanically or manually performed. Therefore, the last two manual sutures and the first two cases operated using mechanical sutures were taken into account. Patients were homogenous for age, general conditions and cancer stage. Upper rectal location was choosen for the comparison considering the use of stapler not essential in this site. Analysis of the course showed no complications, shorter hospitalization, reduced drug therapy, and fewer diagnostic procedures needed in patients operated on with staplers. Although these data have no statistical rank, better surgical results and remarkable saving in social costs were observed with the use of stapling devices.

Adenocarcinoma↗

PubMedDate not supplied

[Hearing loss in workers in the ceramics industry: a profile of the damage assessed by a longitudinal study].

Over the period 1980-1990, 2024 workers in ceramic plants in the Emilia-Romagna region, Italy were evaluated for exposure to noise and hearing loss. Data collected by the National Health Service Local of Occupational and Preventive Medicine Units were used. In a relatively young population (34.8 years mean age, 8.98 years s.d.) exposed for not too long to > 90 dBA noise levels (87.2 for less than 4 years) a statistically significant effect of exposure was found only on the audiometric frequency of 6 kHz (95% confidence interval for mean hearing loss for 1 year exposure to > 90 dBA: 0.05-0.72 dB). An initial isolated loss at the audiometric frequency of 6 kHz was found to be significantly associated with (was a prognostic indicator of) a subsequent impairment at 4 kHz.

Adolescent↗

PubMedDate not supplied

Beta-endorphins ACTH and cortisol in CSF and plasma of HIV infected patients.

Interactions between HPA (Hypothalamic-pituitary-axis) and immune system seem to involve the EPO (endogenous opioid peptides) system, as shown by some recent findings. Possible relationships between beta-endorphin (beta-End) synthesis and severity rate of immunodeficiency have been studied in 48 HIV Ab positive patients, at different stages of infection. A statistically significant decrease in the beta-End synthesis was observed in these patients, as compared to a control group of 19 healthy subjects, but this decrease was not related to the CD4+T lymphocytes number. Plasmatic levels modifications of HPA-related peptides were not observed in the IVC1 CDC group.

Acquired Immunodeficiency Syndrome↗

PubMedDate not supplied

Alteration of thymidine kinase activity in cells treated with an antiviral agent.

A lymphoblastoid cell line, CEM, was rendered resistant to zidovudine (AZT) in vitro by exposure to low but gradually increasing concentrations of the drug. This type of cellular resistance seems to be due to a defect of thymidine kinase (TK) activity that is acquired by cells grown in the presence of AZT. In fact, enzymatic studies with extracts from AZT-resistant cells (CEMazt), have shown that the value of the maximum velocity (Vmax) of TK activity measured with AZT and for deoxythymidine (dThd) is decreased as compared to sensitive CEM cells. Furthermore, the enzyme affinity for AZT and dThd is reduced in CEMazt. Further experiments have shown that such cells do not show resistance to other nucleoside analogs, such as ddI, ddC, AraT and D4T, suggesting that the phosphorylation pathways different from those involving TK are unaltered. Ex vivo experiments performed by using peripheral blood mononuclear cells (PBMC) from HIV infected individuals revealed that a prolonged treatment with AZT may modify the affinity of TK for dThd, thus suggesting that the aforementioned phenomenon may occur also in vivo.

Anti-HIV Agents↗