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Biomedical subjects

F Ferrara

Publications and source records attributed to F Ferrara.

At least 109 records · Page 6Linked to original sources
PubMed1985

Position of ceftazidime in respiratory diseases.

Twenty patients (10 males and 10 females), ranging in age from 53 to 81 years, were treated with ceftazidime, 2-3 g/day i.m., for 12 to 15 days. All patients were suffering from moderate to severe infections of the lower respiratory tract (6 cases of pneumonia and 14 cases of acute exacerbation of chronic bronchitis). In addition, almost all patients presented severe local and general predisposing factors (three patients with lung cancer, two with bronchiectasis and 14 with respiratory insufficiency). The aetiological agents responsible for the infections were mainly Gram-negative bacteria (6 Klebsiella pneumoniae, 4 Haemophilus influenzae, 4 Pseudomonas aeruginosa and 3 Proteus strains). The clinical and microbiological results of the treatment were good. With the exception of one case of maculopapular rash, none of the patients complained of adverse reactions and no toxic effects were observed.

Aged↗
PubMed1985

Physiopathological rationale and clinical aims of the use of a combination of cefuroxime and N-acetylcysteine in pneumology.

The trial population consisted of 50 patients suffering from acute exacerbations of chronic bronchial disease processes. Forty patients were treated with an extempore combination of cefuroxime and N-acetylcysteine at the doses of 2 g and 600 mg/day respectively in two i.m. administrations. The other 10 patients were treated with N-acetylcysteine alone at the same dose. Respiratory tract clinical and instrumental parameters were investigated, and bacteriological tests were performed on sputum samples before and after treatment. Tolerance of the treatment was assessed on the basis of measurement of blood-chemistry parameters.

Acetylcysteine↗
PubMed1984

5-Aza-2'-deoxycytidine induces terminal differentiation of leukemic blasts from patients with acute myeloid leukemias.

In this study, the effects of 5-aza-2'-deoxycytidine on differentiation of human leukemic cells in primary suspension culture are reported for the first time. Morphological and functional differentiation was induced in cells from two acute monoblastic leukemias and two of three acute myeloid leukemias following repeated exposures to 1 mumol/L 5-aza-2'-deoxycytidine. The observation that nontoxic concentrations of the drug are able to induce the in vitro differentiation of both monoblastic and myeloblastic leukemic cells into mature elements may encourage the exploitation of the differentiating properties of 5-aza-2'-deoxycytidine in chemotherapy protocols for acute non-lymphoblastic leukemias.

Azacitidine↗
PubMed1983

[Analysis of a case of multiple myeloma with late dissemination of skin nodules].

A case of a 55 years old woman suffering from multiple myeloma with strong bone marrow proplasmocytic infiltration, several osteolytic and osteoporotic lesions and high seric M-component level and hypertensive heart failure is described. After 32 months of partial remission obtained with cyclic chemotherapy, large cutaneous tumors arose. Despite of a new therapeutic trial, in the last 8 months, an increase of bone marrow and seric signs was observed without involvement of the lungs or kidneys or expression of plasma-cell leukemia. Death occurred at 50th month because of sepsis and heart failure. A real cutaneous tropism, late occurred and without cytohistological changes, is stressed. The meaning of the rich vascularization of the skin over the tumors in absence of inflammation and necrosis remains unclear.

Antineoplastic Combined Chemotherapy Protocols↗
PubMed1981

[Risk factors in the determination of breast cancer].

Early diagnosis of breast cancer presupposes the periodic execution of an array of physical and instrumental examinations. The concept of "risk factors" is needed to single out women for whom screening is desirable. Reference is made to the main risk factors currently recognised, and an attempt is made to determine the extent of their incidence in the determination of breast cancer.

Age Factors↗
PubMed1981

[Surgical treatment of biliary lithiasis associated with acquired valvulopathy].

Personal experience in the treatment of acquired valvulopathies and biliary calculosis in one operating stage is reported. After examination the risk factors determining onset of bile calculosis in valvulopathic patients, the surgical techniques adopted and the special advantages obtained by associating the two operations at the same session are illustrated.

Adult↗
PubMed1981

[Prognostic evaluation of chronic lymphocytic leukemia in relation to the Rai classification. Critical analysis of 145 personal cases].

145 patients suffering from Chronic Lymphocytic Leukemia, observed in the period from 1961 to 1976, were analyzed with regard to prognosis according to following factors: age, sex, Rai staging. Age and sex didn't show to influence median survival. According to Rai staging, and Authors, owing to obtained results, propose a classification in just two stages.

Age Factors↗
PubMed1981

[Mesenteric syndrome following the repair of aortic coarctation. Pathogenetic and clinical findings].

Two cases of mesenteric syndrome were observed in 41 patients undergoing correction of aortic coarctation at the School of Heart and Large Vessel Surgery of the 1st Medical Faculty of Naples University. In the light of the latest theories regarding the pathogenesis of the mesenteric syndrome, post-operative arterial hypertension is held to be a decisive factor in the genesis of the complication. Control of pressure is therefore believed to be of considerable importance in the prevention and treatment of the syndrome.

Adolescent↗