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Biomedical subjects

F Feldman

Publications and source records attributed to F Feldman.

At least 91 records · Page 5Linked to original sources
PubMed1985

Effect of soft-tissue pathology on detection of pedal osteomyelitis in diabetics.

Three-phase bone scans were performed on 30 diabetic patients suspected of having acute pedal osteomyelitis; 23 also had a pedal ulcer, seven had coexisting cellulitis, and 14 had diminished pedal pulses. Fifteen patients were receiving antibiotics at the time of the scan. A tissue diagnosis was available in 18 patients and 12 had no clinical evidence of infection on follow-up. Focal arterial hyperemia combined with focally increased activity on blood-pool and delayed (2-3 hr) scans were interpreted as acute osteomyelitis. Scans showing venous hyperemia were interpreted as soft-tissue pathology without acute osteomyelitis. Companion radiographs were reviewed independently. The sensitivity and specificity of the scans for osteomyelitis were 0.94 and 0.79, respectively, while radiographic sensitivity was 0.93 and specificity was 0.50. The presence of soft-tissue ulcers or cellulitis, peripheral vascular disease, or recent antibiotic therapy had no significant adverse effect on the accuracy of the three-phase scan in diagnosing osteomyelitis.

Adult↗
PubMed1984

Effect of indomethacin on the ocular hypotensive action of timolol maleate.

A randomized, double-masked, cross-over study of nine healthy normal subjects was conducted to determine whether indomethacin affected the ocular hypotensive action of timolol maleate. A significant decrease in intraocular pressure occurred with timolol maleate 0.5% eyedrops (used twice a day) alone. Indomethacin (25 mg three times a day, given orally) administered concurrently had no effect on timolol's hypotensive action. No subjective or objective side effects occurred and there were no significant changes in blood pressure, pulse rate, or respiratory rate with either treatment.

Double-Blind Method↗
PubMed1984

Normal thermographic standards for the cervical spine and upper extremities.

Although thermography has been used for a variety of abnormal conditions, extensive data on large, relatively asymptomatic populations has heretofore not been available. More specifically, no data deal with the upper extremities and, more particularly, no analyses are based on simultaneous thermograms of the posterior neck and shoulders. The current study undertook this task. The results confirm the existence of thermal symmetry in the overwhelming majority of 100 normal relatively asymptomatic, actively employed factory workers. Conversely, if persistent, statistically significant thermal asymmetry exists, as outlined and correlates with patient symptomatology, an organic basis for it should be sought.

Adolescent↗
PubMed1984

Glycosylated fetal hemoglobin. Correlation with hyperglycemia and birth weight in infants of diabetic mothers.

Glycosylated fetal hemoglobin levels were measured in umbilical cord blood of normal infants and infants of diabetic mothers. The glycosylated fraction proved to be a stable compound; its level remained unchanged over a 19-day period. Exposure of fetal and adult hemoglobins to the same concentrations of glucose in vitro resulted in similar levels of glycosylated hemoglobins, suggesting that both types of hemoglobin are about equally reactive with glucose. Levels of glycosylated hemoglobin were significantly increased above normal in umbilical cord blood of infants of both Class A and Class B diabetic mothers. A significant relationship was found between macrosomia, reflected in birth weight ratios, and glycosylated hemoglobin from fetal erythrocytes in infants of diabetic mothers. While these data are consistent with the conclusion that glycosylated fetal hemoglobin levels are a function of fetal blood glucose concentrations in utero during the 2 mo before delivery, it is not known whether the glycosylated hemoglobin contributes to the abnormalities other than macrosomia found in infants of diabetic mothers.

Birth Weight↗
PubMed1984

Effect of cimetidine on intraocular pressure in patients with glaucoma.

The effect of an intravenous infusion of cimetidine, 2 mg/kg of body weight over 1 hour, on intraocular pressure was studied in four patients with medically controlled glaucoma and compared with the effect of a control infusion of normal saline. Cimetidine, a powerful histamine-H2-receptor antagonist, had no effect on the intraocular pressure in any of the patients.

Adult↗
PubMed1983

The symptomatic spine: relevant and irrelevant roentgen variants and variations.

Localized disease of the spine may be related to a variety of etiologies. Although each of these processes may be delineated in a variety of ways, including some of the new imaging modalities, the majority of these lesions can be clearly identified on the basis of routine radiograms. Several types of localized spinal column lesions are discussed, with an emphasis on their appearance on a standard plain film.

Adolescent↗
PubMed1982

Endotoxemia and hyperbilirubinemia in the neonate.

One hundred twenty-five neonates with varying serum bilirubin levels were tested for endotoxin by the limulus amebocyte lysate (LAL) test. Neither infection nor hemolytic disease was a contributing factor to the bilirubin levels. As the serum bilirubin level rose, positive LAL tests increased in frequency until the LAL test attained 100% at a level of 13 mg/dL. Bilirubin at different concentrations did not elicit positive LAL tests in plasma or normal saline in vitro. The LAL test was positive in urine obtained by suprapubic aspiration in 50% of neonates with positive serum LAL tests. Although bilirubin and endotoxin are cleared independently by hepatic cells with different functions, a striking relationship is evident between the endotoxin and bilirubin levels in the neonate. Immaturity of physiological liver functions in the neonate plays an important role. The LAL test cannot be used as an indicator of Gram-negative sepsis in neonates with unconjugated hyperbilirubinemia.

Bilirubin↗
PubMed1982

The variant lumbar pedicle.

Three cases of aplastic and/or hypoplastic lumbar pedicle are presented and discussed. The importance of plain films, especially the 45 degrees posterior oblique, for making the diagnosis is emphasized. The incidence and embryology of abnormalities of the pedicle are reviewed and the radiological features used to differentiate these congenital abnormalities from neoplasm and trauma are described.

Adult↗
PubMed1982

Effect of histamine-2 receptor blockade by cimetidine on intraocular pressure in humans.

The effect of an intravenous infusion of cimetidine (2 mg/kg of body weight/hr) on intraocular pressure and gastric acid secretion was determined in four healthy young adults and compared with the effect of a control infusion of normal saline. Cimetidine, a powerful histamine-2 receptor antagonist, abolished basal acid secretion, indicating that it was pharmacologically active, yet had no effect on intraocular pressure. Therefore, cimetidine may be given safely to patients with normal intraocular pressure. An additional observation was that intraocular pressure in all experiments declined linearly with repeated applanation tonometry for almost two hours before reaching a stable level.

Adult↗
PubMed1982

Liquid crystal contact thermography of deep venous thrombosis.

A new thermographic technique for the diagnosis of deep venous thrombosis, liquid crystal contact color thermography using naturally occurring cholesteric crystals is described. Cholesteric crystals have the property of changing colors in consistent, predictable patterns in response to local temperature changes. The technique is reliable and reproducible. It has also been rendered simple by embedding the liquid crystals in elastic, flexible sheets. The sheets are inflated and readily adapt and contour to extremities of various sizes and shapes. Preliminary results have shown excellent correlation with ascending phlebography. The two methods were in agreement in 90% of cases with no false-negative liquid crystal thermograms. The technique shows promise as a noninvasive screening study for the diagnosis of deep venous thrombosis in high risk patients.

Aged↗
PubMed1982

Sources of variability in the results of applanation tonometry.

Sources of variability in measurements of intraocular pressure (IOP) by applanation tonometry were examined with a repeated 3 X 3 Latin square design that allowed independent extraction of variation attributable to nine patients, three observers and the order in which the observers performed the measurements. The observers, who were experienced, did not differ significantly in the general level of the IOP readings they obtained or in the variability of the readings. The effect of order was significant; there was an approximately linear decrease in IOP with successive measurements, though the difference between the first and second readings was the largest. The intrinsic variability of the IOP readings gave approximate 90% tolerance intervals of +/- 4.5 mm Hg for a single reading and +/- 3 mm Hg for the average of two readings. The mean decrement between the first and second IOP readings, 1.0 mm Hg, implies the need for a consistent protocol for successive sessions of applanation tonometry.

Adult↗
PubMed1981

Removal of hepatitis B surface antigen from a contaminated applanation tonometer.

Hepatitis B surface antigen was found in the conjunctival fluid of 43% of hepatitis B surface antigen carriers and could be detected on the tonometer tip after tonometry in one of four hepatitis B surface antigen carriers whose conjunctival fluid was positive for hepatitis B surface antigen. The Goldmann applanation tonometer tip was contaminated by immersion into solutions containing high concentrations of hepatitis B surface antigen (average 15,000 cpm). Prompt rinsing of the contaminated tonometer in running tap water for ten seconds proved sufficient to remove all detectable hepatitis B surface antigen from the tonometer.

Conjunctiva↗
PubMed1980

Case report 115.

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Adult↗