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Biomedical subjects

F Fekete

Publications and source records attributed to F Fekete.

At least 55 records · Page 3Linked to original sources

[Supra-selective vagotomy in the treatment of perforated duodenal ulcers. Thirty cases report (author's transl)].

Thirty patients with acute perforated duodenal ulcer were managed by supra-selective vagotomy and simple closure of the perforation. There was no operative mortality and a low morbidity. Fourteen patients have had gastric studies between four and thirty-two months after operation. Three patients had transitory epigastric fullness (21%); there was no diarrhea or dumping, but two recurrences (14%). The risk of ulcer recurrence after simple closure is high; supra-selective vagotomy as a definitive ulcer therapy, does not increase operative mortality, and has mild digestive sequelaes, for an acceptable rate of recurrence.

Acute Disease↗

[Current treatment of thoracic oesophageal carcinoma (author's transl)].

Always severe and increasingly frequent carcinoma of the thoracic oesophagus now ranks among the most worrying malignancies. However, the authors' experience concur with recent publications to demonstrate that an a priori pessimistic attitude is no longer justified. The considerable progress achieved in pre- and post-operative care and surgical techniques has reduced to 10% the operative mortality rate and has made surgery the best prospect of comfortable and, possibly, prolonged survival. Radiotherapy and chemotherapy still have a place in the treatment, either alone when surgery is contra-indicated or combined with surgical excision.

Adult↗

Renal structural and functional changes and sodium balance in hypothyroid rats.

Significant retardation in body and kidney growth and in renal glomerular and proximal tubular development was observed in hypothyroid rats in comparison with euthyroid controls. Body mass was found to increase by 40% but kidney mass only by 3.5% over a period of 3 weeks following thyroidectomy in contrast to an average increment of 178 and 113%, respectively, in normal animals. Dissociation was found also in the development of glomeruli and proximal tubules: glomerular size correlated with body weight while tubular size with kidney weight. Single nephron glomerular filtration rate was adapted not to the glomerular as normally but rather to the tubular volume thereby compensating functionally for the dimensional glomerulotubular imbalance. However, despite the decreased filtered and excreted amount of sodium relative to the body weight sodium balance was maintained by depressed tubular reabsorption which was uniformly observed in thyroid deficiency. Because of the uncertainty regarding the direct action of thyroid hormones on the tubular function it is assumed that decreased tubular sodium reabsorption is principally caused by the mechanism subserving the maintenance of sodium balance also in salt loaded normal and sodium sensitive Dahl's rats. This seems to be supported by the exaggerated natriuresis observed both in hypothyroid and sodium sensitive Dahl's rats after saline infusion. Justification of the proposed mechanism needs further investigation.

Animals↗

[Should undernutrition be corrected prior to surgery in patients with cancer of the oesophagus or cardia? (author's transl)].

A prospective study of 40 patients with cancer of the oesophage or cardia considered for surgery showed that 27 had no evidence of protein or calorie deficiency, while 13 had undernutrition. The 18 patients who benefited from ablative surgery belonged to the group with normal nutritional status; none of the undernourished patients could have benefited from resection. Only controlled studies will show whether or not correcting undernutrition is advantageous, but the number of people with both resectable tumour and corrigible undernutrition is probably very small.

Adult↗

Long-term loss of Warren's shunt selectivity. Angiographic demonstration.

Fifteen patients with a patent shunt after distal splenorenal shunt with gastrosplenic disconnection were prospectively studied by angiography three to 36 months after operation. In all patients a collateral circulation from the portomesenteric to the gastrosplenic system was developed through enlarged venous channels. In all patients the portal flow decreased, as suggested by the angiographically assessed degradation of the portal perfusion of the liver and/or the diminution of the diameter of the portal vein. In two patients the portal vein was thrombotic. We conclude that three months after operation distal splenorenal shunt with gastrosplenic disconnection is not hemodynamically different than portacaval laterolateral shunt.

Celiac Artery↗

EEA stapler and omental graft in esophagogastrectomy: experience with 30 intrathoracic anastomoses for cancer.

Experience with the EEA stapler device used in 30 esophagogastric resections for cancer with intrathoracic anastomosis, is reported. The mortality rate was 13.3%. The anastomotic failure rate was 3.3% (1/30) with only one death; three asymptomatic blind fistulas were found on a routine contrast examination of the anastomosis. It is felt that esophagogastric EEA stapled anastomosis associated with an omental graft is a very safe technique.

Adenocarcinoma↗

Superficial oesophageal carcinoma: an oesophageal counterpart of early gastric cancer.

The clinicopathological features of 10 cases of superficial oesophageal carcinoma without lymph node metastasis are reported. Superficial oesophageal carcinoma, an uncommon form of oesophageal cancer, is defined as invasive squamous cell carcinoma confined to the mucosa and submucosa. It includes plaque-like, erosive, papillary and occult types but is not associated with the usual macroscopic features of advanced oesophageal cancer. The main presenting symptom of dysphagia and oesophagitis is a frequently quoted endoscopic diagnosis. Superficial oesophageal carcinoma may be preceded by dysplastic and in situ carcinomatous changes and is probable oesophageal counterpart to early gastric cancer.

Aged↗