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Biomedical subjects

F Falcini

Publications and source records attributed to F Falcini.

At least 163 records · Page 9Linked to original sources
PubMedDate not supplied

[Juvenile rheumatoid arthritis with pauciarticular onset and HLA-A, B, DR in Italian children].

Juvenile Rheumatoid Arthritis is a heterogeneous disease currently divided into different subtypes based on clinical characteristics. Significant alterations in frequencies of HLA-A, B and DR antigens have been described previously in children with pauciarticular onset Juvenile Rheumatoid Arthritis. We report the results of a study on 42 italian children with pauciarticular onset Juvenile Rheumatoid arthritis that partially confirm the literature data.

Arthritis, Juvenile↗
PubMedDate not supplied

[Juvenile rheumatoid arthritis].

Juvenile rheumatoid arthritis (JRA) is the most common rheumatic disease in children. It is one of the more frequent chronic illnesses of childhood and an important cause of disability. Authors review the literature about JRA.

Arthritis, Juvenile↗
PubMedDate not supplied

[Arthropathies related to HLA-B27].

Spondyloarthropathies represent an important problem within the field of chronic childhood arthropathies. Nosology and differential diagnosis are yet unclear. It is important to distinguish spondyloarthropathies from JCA because biological aspects of affected patients, clinical findings, extraarticular manifestations and prognosis are very different. Ankylosing spondyloarthritis is the prototype of spondyloarthropathies: at the beginning, axial involvement is rare; it may develop during the following years or it may not occur. Enthesopathy is an important finding of spondyloarthropathies. Diseases with joint involvement, HLA B27 related, as ankylosing spondyloarthritis, psoriatic arthritis. Reiter's syndrome or arthritis associated with chronic bowel disease, enter the chapter of spondyloarthropathies. Children with familial history of spondyloarthropathies showing enthesopathy, "sausage fingers" and with the presence of HLA B27, may be classified in the group of spondyloarthropathies. Children with a chronic arthritis with pauciarticular onset, B27 positive, without any sign and finding spondyloarthropathies, should be classified as JCA from the beginning. A follow up of children affected with chronic arthritis is fundamental for a more correct classification of the disease.

Adolescent↗
PubMedDate not supplied

[Systemic sclerosis in childhood].

Systemic sclerosis is a multisystem disease of unknown cause, characterized by inflammation, vascular and fibrotic changes with excessive accumulation of connective tissue. The lesions may involve the skin and various internal organs (kidney, lung, gastrointestinal tract and heart). The first symptom is usually Raynaud's phenomenon, followed by skin changes; at the beginning the skin is swollen and oedematous, and then becomes thick, taut, shiny and atrophic. The prognosis of SS depends mainly on the severity of visceral involvement. The treatment of SS consists of drugs that improve the microcirculation and reduce collagen proliferation, such as calcium-antagonists (nicardipine) and D-Penicillamine.

Adolescent↗
PubMedDate not supplied

[Orthotopic liver transplant in pigs: several variations of the surgical technic].

A technique of orthotopic liver transplantation in the pig is presented. The use of a veno-venous cava-portal-jugular shunt during the anhepatic phase helped by a roller pump with moderate systemic heparinization is described. Technical modifications of arterious and biliary anastomosis are described as well. This technique is not only similar to the procedure applied to man, but it also provides a safe and reproducible experimental model. It has produced good results according to a survival rate equal to 95% at 48 hour and 87.5% at one week in the orthotopic liver transplantation in the pig.

Animals↗
PubMedDate not supplied

[Mixed connective tissue disease in childhood. Report of a case].

The Authors report a case of MCTD in a 11 years old girl. Initially the disease presented the classical clinical picture of IDM. Successively its evolution was marked by the appearance of the typical clinical features of JRA, SS and of serum antibodies anti-RNP and by absence of antibodies anti-dsDNA and anti-Sm. These data are characteristic of MCTD. The occurrence of this disease in children is extremely rare and the prognosis is related to a possible renal and/or haemopoietic involvement.

Child↗
PubMedDate not supplied

[Sjogren-Larsson syndrome. Description of a case].

The authors describe a typical case of Sjogren-Larsson Syndrome showing a clear improvement of the spastic paresis after 2 years of physiotherapy and a diet rich in polyunsaturated fatty acids.

Fatty Acids, Unsaturated↗
PubMedDate not supplied

[Mucha-Habermann disease. Description of a case in childhood].

The authors report a case of Mucha-Habermann disease in childhood. Mucha-Habermann disease is not a very well known, though not infrequent, disease. It is characterized by recurrent erythematous-papular-vesicular skin lesions associated with arthralgia or arthritis or large joints. Prognosis is generally favourable although an evolution towards Pityriasis Lichenoides Chronica and/or Mycosis Fungoides is possible. There are not specific laboratory findings for this form. Diagnosis is essentially based on histology showing an immunopathogenetic vasculitis. At the present time there is not a safe therapy for the disease; there are however indications for the use of Erythromycin and we followed these in our therapy with positive results.

Arthritis↗
PubMedDate not supplied

[Schoenlein-Henoch syndrome. Renal involvement and prognosis].

We have studied the incidence of renal involvement, the severity and the clinical course of nephropathy in 83 children, 47 males and 36 females, aged from 2 to 13 years, who were under observation for SSH at the II Pediatric Clinic, Florence University. In 72.3% of cases, we have not observed any sign of renal involvement, at least within 6 months of onset of the syndrome. In 16.3% we have observed persistent urinary abnormalities: these findings have returned to normal within 1 year in 13 children and within 3 years in one child. In 10.8% of cases, a nephropathy has appeared, in all of the cases within 3 months of onset. Only one case has developed renal failure 5 years after onset. We can conclude that a good correlation exists between clinical manifestations of this disease and histopathologic changes; that therapy is of little value in modifying the clinical course; that renal failure is a rare occurrence.

Acute Kidney Injury↗
PubMedDate not supplied

[A case of systemic sclerosis in childhood complicated by severe digital ulcers].

Systemic sclerosis is a diffuse disorder of connective tissue in which there are inflammatory, fibrotic and degenerative changes in the skin and many internal organs. We describe a case of systemic sclerosis type "acrosclerosis" in a six years old child with Raynaud's phenomenon and gastrointestinal involvement. In the course of illness he presented severe digital ulcerations in the hands and in the feet, responsive to a calcium channel blocking agent nifedipine treatment.

Child↗
PubMedDate not supplied

[Bilateral extrinsic ophthalmoplegia in infectious mononucleosis].

The AA. describe an eight years old child with extrinsic bilateral ophthalmoplegia associated with infectious mononucleosis. On the right (eye) a compromise of the VI (partial) and the III (total) pairs of cranial nerves was evident. On the left all extrinsic oculomotor nerves were interested.

Child↗
PubMedDate not supplied

[Mucocutaneous lymph node syndrome].

Authors describe two new cases of mucocutaneus lymphonode syndrome (MCLS). These are the tenth and eleventh in Italy since 1977, confirming that this syndrome, known also as Kawasaki disease, is world-wide spread. More attention is therefore required to diagnosis particularly for possible coronary artery involvement. Echocardiography may be useful in doing that. A survey of recent literature indicates that salicylate therapy may be useful not only for symptoms relief but also in preventing life threatening of coronary artery vasculitis.

Child, Preschool↗
PubMedDate not supplied

Reactive arthritis triggered by Yersinia enterocolitica: a review of 18 pediatric cases.

Over a period of four years 18 children seen in our clinic have been diagnosed as suffering from Yersinia enterocolitica reactive arthritis: this group constitutes one third of the total reactive arthritides seen by us. The diagnosis was based on elevated specific antibody titres and the outcome has always been good with anti-inflammatory therapy, symptoms disappearing within a few weeks without any complications or recurrences. This positive outcome could be due to the absence of the HLA B27 haplotype. Yersinia has been described as the most frequent agent causing reactive arthritis, a common complication in an otherwise benign infection in children. It seems that Yersinia may trigger in predisposed hosts an immunological reaction leading to arthritis.

Age Distribution↗
PubMedDate not supplied

Immunological findings in Kawasaki disease: an evaluation in a cohort of Italian children.

OBJECTIVE: Multiple humoral and cellular abnormalities in Kawasaki disease (KD) have already been described. In this study an analysis of immunological findings in a cohort of 34 Italian children affected with KD is reported, and the potential clinical significance of such alterations in predicting the development of coronary aneurysm and the prognosis of the disease is evaluated. METHODS: Levels of circulating immune complexes (CIC), antinuclear antibodies (ANA), anticardiolipin (aCL), antineutrophil cytoplasmic antibodies (ANCA), and anti-endothelial cells (AECA) and the T cell profile were determined in both the acute and the convalescent phases, and were compared to febrile, sex- and age-matched children. RESULTS: CIC were present in 66% of the patients, 18 of whom were in the acute phase and 13 in the convalescent phase. In the control group CIC were detected in 47% of the children. ANA were negative in both the KD and in the febrile group. ANCA were present in 8%, AECA in 26%, and aCL in 30% of KD patients (IgG aCL antibodies were found in 14 patients, IgM aCL in, 1 and 1 had both). Among the controls, aCL antibodies were found in 5 patients (22%); in particular 1 (4.4%) had IgG and 4 (17.4%) had IgM aCL. An altered T cell profile, with an inverted CD4/CD8 ratio, was found in all KD children. All of the immune alterations showed a lower incidence in the convalescent than in the acute phase. No significant relationship between any of these immune findings and cardiac involvement or any other clinical manifestations was found. CONCLUSION: Our data confirms the previously reported immunological anomalies in KD both in the acute and the convalescent phases, with a decreased incidence of such alterations in the convalescent phase. No prognostic significance for the occurrence of aneurysm could be demonstrated.

Antibodies, Anticardiolipin↗