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Biomedical subjects

F F Marshall

Publications and source records attributed to F F Marshall.

At least 145 records · Page 8Linked to original sources
PubMed1981

A comparison of ultrasonography and radiography in the localization of renal calculi: experimental and operative experience.

The capabilities of radiography (mammography film) and ultrasonography (7 MHz. probe) were investigated in cadaver kidneys. Stones of varying size and composition were studied. Clinically, 11 patients then were studied with intraoperative radiography and ultrasonography. Both techniques appeared to localize calculi more than 3 mm. with high consistency in cadaver kidneys and in patients. Real-time B scan ultrasonography is a rapid and accurate technique that has the ability to identify lucent calculi. When used in association with intraoperative radiography, intraoperative ultrasonography can be a great aid in the surgical removal of renal calculi.

Adult↗
PubMed1981

Quantification of arteriovenous shunting in renal cell carcinoma.

Arteriovenous shunting was quantitated with 20 plus or minus 10 mu 99mtechnetium human albumin microspheres in 12 patients with angiographically hypervascular renal cell carcinomas. Arteriovenous shunting was diagnosed angiographically when the renal vein was opacified during the arterial phase. With use of an angiographic catheter 2 to 3 mCi. 99mtechnetium human albumin microspheres were first injected into the renal artery directly supplying the tumor. Thereafter, 0.5 to 1 mCi. microspheres were injected into the inferior vena cava. Scintillation counts over the right lung were obtained immediately after each injection. The ratio between the 2 counts established the rate of tumor shunting after correction for dose difference and decay. Nine patients without angiographic evidence of arteriovenous shunting had mean shunt rates of 15 per cent, whereas 3 patients with angiographically visible shunting had significantly higher shunt rates of 57 per cent (p less than 0.001). It is concluded that angiography discovers only massive arteriovenous shunting in patients with renal cell carcinoma, whereas a fair degree of arteriovenous shunting may go undetected. The significance of minimal or moderate arteriovenous shunting in patients with renal cell carcinoma needs further investigation. The microsphere quantitation method can be applied routinely to angiography.

Adenocarcinoma↗
PubMed1981

Computed tomography in calcified renal masses.

Five patients with calcified renal masses were evaluated with angiography and postcontrast computed tomography (CT). Computed tomography showed no contrast enhancement of the mass in four patients, three with avascular hypernephromas and one with a renal cyst; in each case, the lesion was totally avascular on angiography. In the fifth case, the lesion enhanced on CT and proved to be an aneurysm. It is concluded that angiography is most informative in calcified renal masses that demonstrate contrast enhancement on CT.

Adenocarcinoma↗
PubMed1981

Vasectomy: subclinical pathologic changes.

The nature of the local histopathologic changes secondary to vasectomy is described in tissue excised at vasovasostomy in 37 secondarily infertile patients. Segments of surgically removed vasa were also studied in four patients with primary infertility who underwent scrotal explorations and subsequent vasoepididymostomy. Except for infertility, all patients were asymptomatic. Three, often concurrent, inflammatory or proliferative changes were found in 50 of 76 segments of vasa deferentia. These included suture granuloma, sperm granuloma, and vasitis nodosa, the last being a ductular proliferation originating from the central vas lumen and extending into the perivasal soft tissues. Vasitis nodosa occurred in 66% of the patients, and although it was often found with a sperm granuloma, it did occur by itself and is a lesion which should be recognized.

Granuloma↗
PubMed1980

Neonatal bilateral ureteropelvic junction obstruction.

The incidence of bilateral ureteropelvic junction obstruction appears to be higher in patients less than 1 year old. The aggressive surgical reconstruction of bilateral ureteropelvic junction obstruction in 3 neonates resulted in good renal function, even in an apparently dismal clinical setting.

Female↗
PubMed1980

Renal cyst versus tumor: a continuing dilemma.

We report on 13 patients with renal cystic lesions who underwent full radiological investigation and remained undiagnosed preoperatively. Of 13 cysts 3 ultimately proved to be malignant at surgical exploration. A retrospective review of these cases failed to reveal any additional features that would have aided in preoperative diagnosis. Despite the high accuracyobtainable by radiological investigation, diagnostic surgical exploration is warranted in a small proportion of patients with renal cystic lesions.

Adenocarcinoma↗
PubMed1980

Vaginal agenesis.

Development of the normal vagina is dependent on the mesonephric duct, paramesonephric duct, and urogenital sinus. A mesonephric anomaly may account for vaginal agenesis, and this defect also explains the associated genitourinary abnormalities. Patients usually present with primary amenorrhea and have a normal female phenotype with normal karyotype and hormonal function. Vaginal reconstruction has most commonly been carried out by use of a split-thickness skim graft with successful long-term results.

Female↗
PubMed1980

Focal xanthogranulomatous pyelonephritis in adulthood.

In adults with xanthogranulomatous pyelonephritis (XGP) focal involvement occurs in 17% Of patients and the remainder have diffuse involvement of the kidney. Most patients are in the fourth and fifth decades. There appears to be a predilection for the left kidney, and 60% of patients will have a positive urine culture. Radiographically, a poorly-functioning, hypovascular renal mass is seen. The clinical and pathological presentations of focal XGP can closely resemble clear-cell renal cell carcinoma, but partial nephrectomy is the preferred treatment for this inflammatory disorder. We discuss three adults with focal XGP who have been treated at The Johns Hopkins Hospital in the past 2 1/2 years.

Adenocarcinoma↗
PubMed1979

Late hemorrhagic cystitis following low-dose cyclophosphamide therapy.

Hemorrhagic cystitis is a recognized acute complication of cyclophosphamide (Cytoxan) therapy in the treatment of malignant disease. More recently, lower dose, long-term cyclophosphamide therapy has been used in the treatment of autoimmune diseases including rheumatoid arthritis. In 3 patients hemorrhagic cystitis developed after long-term cyclophosphamide therapy for rheumatoid arthritis. Even in low dosage, this drug may cause hemorrhagic cystitis.

Aged↗
PubMed1979

Urogenital sinus abnormalities in the female patient.

Three patients with a urogenital sinus and 1 with a cloaca presented with complex diagnostic and therapeutic anomalies. A classification of these and other vaginal anomalies is based on the theory that they all represent an arrest in normal embryological development. Six categories are described, including vaginal agenesis, urogenital sinus, vaginal atresia, vaginal septa, vaginal stenosis and cloaca.

Cloaca↗
PubMed1979

Epididymal abnormalities associated with undescended testis.

In a prospective study of 42 patients with undescended testes 15 (36 per cent) had epididymal abnormalities. These anomalies were divided into 3 groups, including agenesis of the epididymis, atresia of the epididymis and loop or elongated epididymis. In the second group atresia could occur at the head, body or tail of the epididymis.

Abnormalities, Multiple↗
PubMed1979

The embryologic origin of the caput epididymidis in the rat.

The ACI rat with its known incidence of ipsilateral agenesis of the kidney and ductus deferens provides an excellent mammalian model for the study of the embryologic origin or the caput epididymidis. Because a portion of the caput epididymidis remains in these affected animals, it seems to be derived from the mesonephric tubules rather than the mesonephric duct in the rat. Histochemical assays also support the common origin of both the ductuli efferentes and caput epididymidis from the mesonephric tubules.

Alkaline Phosphatase↗
PubMed1978

Hydronephrosis, renal agenesis, and associated genitourinary anomalies in ACI rats.

The ACI rat provides a congenital mammalian model for the spontaneously occurring defects of renal agenesis and hydronephrosis. These anomalies appear to be part of a spectrum of abnormalities caused by a mesonephric duct defect. These same anomalies also exist in man probably more commonly than previously appreciated.

Abnormalities, Multiple↗