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Biomedical subjects

F F Marshall

Publications and source records attributed to F F Marshall.

At least 19 recordsLinked to original sources

Intraoperative sonography of renal tumors.

Intraoperative sonography (7.5 MHz. transducer with Doppler probe) was used to evaluate renal masses in 41 kidneys to determine its correlation with pathological findings. This intraoperative determination of the extent of the renal lesion prompted occasional changes in surgical management. We conclude that intraoperative sonography is most useful in partial nephrectomy, and helps to determine the extent of tumor, multicentricity, venous extension and associated cysts. These findings may not be appreciated with intraoperative, visual inspection of the kidney.

Humans

Late hemorrhagic cystitis following low-dose cyclophosphamide therapy.

Hemorrhagic cystitis is a recognized acute complication of cyclophosphamide (Cytoxan) therapy in the treatment of malignant disease. More recently, lower dose, long-term cyclophosphamide therapy has been used in the treatment of autoimmune diseases including rheumatoid arthritis. In 3 patients hemorrhagic cystitis developed after long-term cyclophosphamide therapy for rheumatoid arthritis. Even in low dosage, this drug may cause hemorrhagic cystitis.

Aged

Urogenital sinus abnormalities in the female patient.

Three patients with a urogenital sinus and 1 with a cloaca presented with complex diagnostic and therapeutic anomalies. A classification of these and other vaginal anomalies is based on the theory that they all represent an arrest in normal embryological development. Six categories are described, including vaginal agenesis, urogenital sinus, vaginal atresia, vaginal septa, vaginal stenosis and cloaca.

Cloaca

Epididymal abnormalities associated with undescended testis.

In a prospective study of 42 patients with undescended testes 15 (36 per cent) had epididymal abnormalities. These anomalies were divided into 3 groups, including agenesis of the epididymis, atresia of the epididymis and loop or elongated epididymis. In the second group atresia could occur at the head, body or tail of the epididymis.

Abnormalities, Multiple

The embryologic origin of the caput epididymidis in the rat.

The ACI rat with its known incidence of ipsilateral agenesis of the kidney and ductus deferens provides an excellent mammalian model for the study of the embryologic origin or the caput epididymidis. Because a portion of the caput epididymidis remains in these affected animals, it seems to be derived from the mesonephric tubules rather than the mesonephric duct in the rat. Histochemical assays also support the common origin of both the ductuli efferentes and caput epididymidis from the mesonephric tubules.

Alkaline Phosphatase

Hydronephrosis, renal agenesis, and associated genitourinary anomalies in ACI rats.

The ACI rat provides a congenital mammalian model for the spontaneously occurring defects of renal agenesis and hydronephrosis. These anomalies appear to be part of a spectrum of abnormalities caused by a mesonephric duct defect. These same anomalies also exist in man probably more commonly than previously appreciated.

Abnormalities, Multiple

Long blind-ending ureteral duplications.

Long blind-ending ureteral duplications can be symptomatic and require surgical intervention. Three patients with long blind-ending ureteral duplications had prominent reflux and required either resection of the blind ureter and ureteral reimplantation or nephroureterectomy.

Adolescent

Crossed renal ectopia.

Crossed renal ectopia is an unusual congenital anomaly, probably produced by abnormal development of the ureteral bud. The deformity itself produces no symptoms and the clinical presentation generally is for obstruction and infection. In our series the adult patients presented most commonly with urinary tract infections, while the pediatric patients presented most often with multiple congenital anomalies, especially of the skeletal system.

Abnormalities, Multiple

The association of uterine and renal anomalies.

The ACI rat provides a mammalian model for the study of spontaneously occurring defects of partial uterine agenesis and renal agenesis. A variable uterine deformity also occurs with hydronephrosis. A mesonephric duct defect appears responsible for these anomalies.

Abnormalities, Multiple

Vaginal abnormalities.

The embryologic development of the vagina is still disputed. The urogenital sinus and the mesonephric (wolffian) and paramesonephric (müllerian) ducts probably all play a role in the development of the vagina. Duplication, agenesis, mesonephric duct remnants, and hymen abnormalities are among the more common congenital anomalies of the vagina.

Female

Embryology of the lower genitourinary tract.

The urinary and genital systems are closely related in their development so that dividing them into separate divisions is often artificial. The lower urinary system begins as a cloaca. The urorectal septum then divides the cloaca into a ventral urogenital sinus and a dorsal hindgut. The ureteral bud forms off the mesonephric duct. The male and female genital systems are the same until the gonad assumes characteristics of the testis or ovary in the eighth week of gestation. It is not until the eleventh or twelfth week that the external genitalia assume specific sexual characteristics. Anomalies of the urethra and bladder can vary from a severe epispadias-exstrophy complex to a minimal Type I urethral valve. Ureteral anomalies include duplications, ectopia, and ureteroceles. An undescended testis is probably the most common anomaly in the male genital tract. Female genital anomalies can include a variety of uterine duplication anomalies. Gonadal abnormalities are often created by a chromosomal defect and are ultimately reflected by abnormal sexual differentiation.

Cloaca

Multicystic dysplastic kidney.

We reviewed 29 cases of congenital multicystic dysplastic kidneys. Isolated renal pelvic atresia has an excellent prognosis but lower ureteral atresias are associated with a high incidence of contralateral renal disease and have a worse prognosis.

Abnormalities, Multiple

Severe blunt trauma of upper urinary and intestinal tracts in a child.

A 7 1/2-year-old boy sustained severe trauma to the upper abdomen, including transection of the common bile duct, transection of the second part of the duodenum, contusion of the head of the pancreas, traumatic thrombosis of the left renal artery, thrombosis of the right lower pole renal vasculature and avulsion of the right renal pelvis. A staged elective repair of the upper urinary tract, and later the upper gastrointestinal tract, was accomplished when he was referred 5 1/2 months after the initial injury.

Child

Partial duplication of the male urethra.

A case of partial duplication of the male urethra (bifid urethra) is presented. This case is unusual because of the late presentation with incontinence, the normality of the primary urethra and the markedly lateral course of the accessory urethra. An anatomic and embryological classification is presented.

Child

Open ureterocolonic anastomoses.

A simple technique for open ureterocolonic anastomosis is presented. This technique provides adequate exposure for mucosal-to-mucosal approximation and allows the construction of an antireflux ureterocolonic anastomosis.

Colon