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Biomedical subjects

F F Madsen

Publications and source records attributed to F F Madsen.

30 records · Page 2Linked to original sources
PubMed1990

Regional cerebral blood flow in the pig after a localized cerebral contusion treated with barbiturates.

Regional cerebral blood flow determined with microsphere technique in anaesthetized pigs was measured before and after a localized cerebral contusion as well as after treatment with pentobarbital. No overall reduction in intracranial pressure or perfusion pressure was observed. Flow reduction due to pentobarbital was different in different regions with a high percentage change in the highly perfused basal structures and cortical grey matter except in the centre of the contusion where the reduction was half compared to the rest of cortical grey matter. Changes in white matter were less than in cortical grey matter but more pronounced than in the very high flow areas (choroid plexus and pineal gland). The accumulated change was greatest in the damaged region. Contralateral to the contusion, where a significant increase in flow was noticed after the contusion, there was a very low accumulated change in flow. In white subcortical matter underlying the contusion a similar low flow change was observed but this was not accompanied by as large an accumulated change as in grey cortical matter. At each fraction of injected pentobarbital a short-lasting increase in intracranial pressure and a reduction in mean arterial blood pressure was observed. The amplitude and the height of the intracranial pressure change was reduced during the pentobarbital injections.

Animals↗
PubMed1990

Changes in regional cerebral blood flow after hyperventilation in the pig with an induced focal cerebral contusion.

Changes in regional cerebral blood flow in anaesthetized pigs with an induced focal cerebral contusion were studied before and after two grades of hyperventilation. A reduction in arterial tension of CO2 with 0.70 mmHg and a further reduction of 0.55 mmHg did not change the CO2 reactivity. Reactivity in both injured and macroscopically normal regions was the same, revealing an average of 39.3% flow change per kPa change in CO2 tension. Regions with low flow after the contusion had an equally big reduction apparently leading to hypoxia because global metabolic rate was unchanged.

Animals↗
PubMed1989

[Surgical treatment of cervical spondylotic myelopathy. A follow-up study].

The effect of operative treatment of spondylotic cervical myelopathy (SCM) was assessed by a follow up investigation of 33 patients submitted consecutively to operation. The patients were followed up on an average two years and two months after operation. As compared with the preoperative status, 39% of the patients had improved, 27% remained unchanged and 33% had a clinical status which was poorer than preoperatively. Age and sex were not found to be of significance for the prognosis. Patients with brief case histories had better effects of operation than patients with prolonged duration of the condition. The best results were found in patients in whom the duration of the condition was less than one year. Although 66% patients had obtained improved clinical condition or in whom progression of the condition has been arrested, 82% of the patients had been awarded social pensions at follow up examination as compared with 48% preoperatively. It is concluded that treatment of SCM should be instituted as early as possible in the course of the condition in the form of operative decompression of the cervical medulla.

Adult↗
PubMed1988

Cortical blood-flow in the porcine kidney. A radioactive microsphere study.

Renal cortical blood-flow distribution was measured by means of radiolabeled microscopheres in eight kidneys from 4 pigs of mixed Yorkshire and Danisk landrace. We found a pronounced intracortical variation in the perfusion pattern of 28 sections of outer cortex. Three consequetive flow determinations with an interval of 45 minutes showed that the heterologous perfusion pattern was plastic, changing between the flow-determinations. In addition, we found a significantly reduced perfusion in the renal poles, compared to the rest of the outer cortex. It is speculated that the reduced polar perfusion is a contributing aetiological factor to the increased incidence of polar scar formation secondary to reflux nephropathy.

Animals↗
PubMed1987

A simple mechanical model using a piston to produce localized cerebral contusions in pigs.

A simple mechanical model using a piston to produce localized cerebral contusions in pigs, is presented. The precision and reproducibility of the method are described by the biomechanical and pathological results. There are only pathological changes with haemorrhage and laceration close to the place of entry of the piston. The changes in the physiological parameters also indicate that the damage is focal. In this model, when kept intact, the dura mater offers considerable protection as no pathological changes in the brain are observed even when the energy at the time of the contusion is increased to twice the values which, when the dura is open, cause considerable damage.

Animals↗
PubMed1987

Cerebral gumma.

A patient presented with symptoms from a tumour in the frontal region. Syphilis had been treated 15 years earlier but the serological tests were inconclusive on this admission. The CT-scan showed oedema surrounding a contrast enhancing tumour. Angiography showed displaced but otherwise normal vessels. Histologically the lesion proved to be a gumma.

Adult↗
PubMed1985

Lymphocytic adenohypophysitis. A review and a case.

An unconscious, 29-year-old woman was taken to hospital where, 28 hours after admission, she succumbed to an intractable shock. Autopsy disclosed a lymphocytic adenohypophysitis (LAH). Judged by experiments on animals and by antibody examinations in women during puerpera, LAH is probably an autoimmune disease belonging to a group of autoimmune endocrinopathies, from which one or more is seen with LAH. The description of the present case is accompanied by a description of the disease in eight cases, all women; in only one patient was the diagnosis not made by autopsy. The patients can be divided into two groups, one group consisting of postmenopausal women, another who all became ill approximately one year after giving birth. It is suggested that this histopathological diagnosis also has a clinical significance.

Adult↗
PubMed1983

Neurogenic intermittent claudication.

Twenty-six patient treated for neurogenic intermittent claudication (NIC) have been examined on an average of 25.5 months after a decompression operation. Twenty-two of the patients were either considerably better (15 patients) or completely free of symptoms (7 patients). Pre-operatively two thirds of the patients were able to walk less than a 100 metres. Post-operatively 12 of the patients had an unlimited walking distance.

Adult↗
PubMedDate not supplied

Papillary glioneuronal tumor--a new tumor entity.

Glioneuronal neoplasms of the CNS comprises a heterogeneous group of generally low-grade tumors expressing glial and neuronal cells of varying differentiation. Recently, a new variant of the glioneuronal tumors has been identified. We present a case of a glioneuronal tumor located in the left frontal lobe of a 16-year-old boy who developed seizures 6 months after brain concussion. MR scan demonstrated an irregular, but well circumscribed, mixed cystic and solid tumor with contrast enhancement in the solid part. Histology showed a papillary glioneuronal tumor. The tumor is indolent with no sign of recurrence after gross total resection.

Adolescent↗