Biomedical subjects
Publications and source records attributed to F F Bartone.
Since 1979 more than 50 transperineal interstitial implants, both removable and permanent, have been performed at the University of Nebraska Medical Center. The "C" arm of the mobile image-intensifier television unit Siemens Mobile 2 was used to guide the placement of the needles and was found to be useful in achieving accurate implantation.
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We studied testicular tissue and peripheral blood samples for chromosomal anomalies in 50 consecutive patients who underwent orchiopexy. Of the 50 subjects 48 demonstrated karyotypes of 46XY in blood and testicular tissue, 1 had Klinefelter's syndrome and 1 had mosaic trisomy 8 with a discrepancy between the blood and testicular chromosomal complement. Over-all, the study showed no significant discrepancy between the chromosomal complements of the testicular tissue and blood. The incidence of these anomalies is not statistically significant compared to the observed frequency of chromosomal anomalies in this age group.
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Although Iodine-125 seeds for interstitial radiation of prostatic cancer via the retropubic route is an established method of treatment, the retropubic implant technique has disadvantages: inadequate space for proper placement of the needles, possible bleeding from the prostatic venous plexus by the insertion of needles through these veins, and possible wound infection due to inadvertent puncturing of the bladder and/or rectum by the needles. A technique is described whereby Iodine-125 seeds for interstitial radiation are placed into the prostate through the perineum allowing more accurate placement of the seeds, assuring homogenous dose distribution, and decreasing the risk of bleeding and of bacterial contamination.
Retropubic I-125 implantation of the prostate at the time of suprapubic extraperitoneal pelvic lymphadenectomy is a well-established method of treatment for stages B(2) and early C prostatic cancer. However, there are some technical disadvantages with the retropubic I-125 implant technique, such as inadequate space for proper placement of the needles; bleeding, uncontrollable at times, from the periprostatic venous plexus secondary to insertion of needles into the prostate; and superficial wound infection due to inadvertent puncturing of the bladder and/or rectum by the needles. In this paper the authors describe a new technique which eliminates the technical problems associated with retropubic I-125 implantation of the prostate.
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The application of ultrasonographic and percutaneous needle puncture techniques in the diagnosis of various fluid-filled renal anomalies has permitted rapid delineation of anatomic detail, more definitive physiologic evaluation, and drainage, when necessary, in a safe and cost-effective manner. Its usefulness in children is emphasized in 6 illustrated cases of male infants with minimally or nonopacified renal anomalies, one of the more difficult diagnostic problems in pediatric urology.
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The reaction of the urethra to two new polyurethrane polymers was compared with those produced by materials currently used in the manufacture of urethral catheters. The comparison included silicone, latex rubber, tetrafluoroethylene polymer (Teflon) coated latex, and polyvinyl chloride. There were no significant differences in the reaction of the urethra to the various materials. The present study was carried out in the absence of bacterial contamination.
Cystotomies in guinea pigs and ureteral anastomoses in dogs were sutured with polyglactin 910. Silk and chromic catgut were used as control sutures in the bladders and chromic catgut in the ureters. Three months postoperatively in bladders sutured with polyglactin 910 small epithelial cysts were noted, which increased in size with time. In ureters sutured with polyglactin 910 cystic diverticula were observed eight months postoperatively. Because of the difference of tissue reaction to polyglactin 910 compared with catgut, further long-term studies are urged in different species of animals, prior to the clinical use of polyglactin 910 in the urinary tract.
Nineteen children who underwent extensive nephrotomies and anatrophic nephrotomies for staghorn calculi (bilateral in 4 cases) are presented. Proteus infection was the cause of the calculus in most cases. In the absence of recurrent stones, renal growth and function were excellent post-operatively. Stone recurrence was minimal if all calculi were removed and infection was controlled. Followup ranged from a few months to 13 years.
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Autoradiographs of healing ureteral defects demonstrated significant uptake of tritiated thymidine in pigs sacrificed during the first 2 weeks after ureterotomy. The earliest and most heavily labeled tissue was epithelium followed by proliferation of subepithelial connective tissues and smooth muscle of the muscularis. The labeling of significant numbers of myocytes within the muscularis was indicative of smooth muscle replacement by hyperplastic means. The fact that most mitotically active smooth muscle cells were seen in the muscle remnant adjacent to wound margins suggests this as the primary source for new muscle.
Reaction of catgut and collagen sutures in both wounded and nonwounded bladder, kidney, muscle, and liver tissue was studied in guinea pigs up to 130 days after implantation. A minimal amount of degradation of ths so-called absorbable sutures was observed. There was little difference in absorption rates in the tissues studied although there seemed to be slightly greater absorption in the kidney than in other tissues. Tissue responses were characterized by the formation of a bilaminar connective tissue capsule. The inner zone contained primarily fibroblasts and histiocytes, while lymphocytes, neutrophils, and eosinophils were scattered throughout both layers. Multinucleated giant cells were often observed in the inner layer, and aggregates of lymphocytes and mast cells were occasionally found in the pericapsular areas. Calculi formed on those suture loops that were loosely tied and thus projected into the bladder lumen.