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Biomedical subjects

F Eulderink

Publications and source records attributed to F Eulderink.

At least 73 records · Page 4Linked to original sources
PubMed1986

Reticular erythematous mucinosis syndrome in a patient with polyarthritis.

A patient with seronegative oligoarthritis who developed the reticular erythematous mucinosis (REM) syndrome is described. This syndrome is considered to be a dermatological entity unrelated to systemic disorders. Aggravation of the rash by exposure to sunlight and a good response to anti-malarial agents suggest a relationship with rheumatological disorders, e.g. rheumatoid arthritis and systemic lupus erythematosus. Dermatologists consulted by a patient with the REM syndrome should be aware of the possibility of an associated rheumatological disease.

Adult↗
PubMed1984

Diffuse (eosinophilic) fasciitis. A series of six cases.

Six patients with diffuse fasciitis are described. Their ages range from 12 to 45 years. Five had a typical clinical illness which responded well to corticosteroid therapy but one patient relapsed a year after discontinuation of corticosteroids. One patient had severe skin ulceration resistant to corticosteroids, cytotoxics and plasma exchange and was further complicated by the development of life threatening local and generalised sepsis. Eosinophilia of the blood was not present in any of the cases and not unduly prominent in biopsies of the affected tissue, but characteristic fascial thickening and infiltration by chronic inflammatory cells was diagnostic when a full-thickness biopsy was examined. The natural history and optimal treatment of this condition remain unclear.

Adolescent↗
PubMed1984

Systemic lupus erythematosus and invasive thymoma: report of two cases.

Two cases of invasive thymoma in patients with systemic lupus erythematosus (SLE) are described. In both instances the suspected diagnosis of a mediastinal tumour proved difficult to confirm. Neither surgical removal of the thymoma in one case nor irradiation in the other had any apparent clinical or serological effect on the course of the SLE. Both patients subsequently suffered from respiratory problems and the distinction between recurrent tumour and pulmonary involvement by SLE proved difficult. One patient had a good response, however, to pulse methylprednisolone, but the other later developed recurrence of tumour and died of Pneumocystis carinii infection following cytotoxic therapy three years after discovery of the tumour.

Female↗
PubMed1982

Role of granulocytes in experimental Streptococcus sanguis endocarditis.

We investigated the role of granulocytes during the induction and course of experimental Streptococcus sanguis endocarditis in rabbits by depleting blood granulocytes with nitrogen mustard. The induction of the endocarditis was not influenced by granulocytopenia: the 50% infectious dose was 5.4 X 10(4) colony-forming units in normal and granulocytopenic rabbits. However, granulocytopenia influenced the curse of the endocarditis, as shown by a significant increase in the number of colony-forming units per gram of vegetation (P less than 0.02) from 24 to 72 h after the injection of 10(5) colony-forming units of S. sanguis. This rise did not occur in the control rabbits. Furthermore, bacteremia was significantly higher in the granulocytopenic rabbits (P less than 0.05) during the first 48 h compared with the control rabbits. This was not because of altered clearance of the streptococcus inoculum or seeding of streptococci from extracardiac bacterial foci. We concluded that granulocytes have no measurable effect on the induction of S. sanguis endocarditis, but during the course of the endocarditis, granulocytes keep the endocardial infection in check.

Agranulocytosis↗
PubMed1981

Mobility and degenerative changes of the ageing cervical spine. A macroscopic and statistical study.

In our morphological and kinesiological study, degenerative changes of the human cervical spine became more frequent and severe with advancing age. Disk splits and diarthrodial cartilage loss were the first lesions to appear. Apophyseal osteophytes arose approximately two decades after apophyseal cartilage loss, paradiscal osteophytes two decades after disk splits and irregularity of the vertebral end-plates 10-15 years after the appearance of paradiscal osteophytes. Because all these degenerative lesions are associated with loss of mobility, advancing age is correlated with decreasing mobility as well. In the absence of progression of any degenerative lesion, however, no change in mobility was found.

Adult↗
PubMed1980

Gastrointestinal telangietasia as a cause of severe blood loss in systemic sclerosis.

Two patients with progressive scleroderma had severe gastrointestinal blood loss. Endoscopical examination revealed multiple telangiectase in the upper gastrointestinal tract, especially in the stomach. The telangiectases in the skin and the mucosa in systemic sclerosis are indistinguishable endoscopically and histologically from those seen in hereditary hemaorrhagic telangiectasia. Recurrent and severe gastrointestinal hemorrhage originating from telangiectases is an unusual complication of systemic sclerosis.

Female↗
PubMed1980

Effects of monocytopenia and anticoagulation in experimental Streptococcus sanguis endocarditis.

The role of blood monocytes in the attachment of streptococci to endocardial vegetations was investigated in an experimental Streptococcus sanguis endocarditis by depletion of blood monocytes with the cytostatic drug VP 16-213 alone and combined with anticoagulant treatment with warfarin sodium. The numbers of streptococci in the vegetations of control, monocytopenic, and monocytopenic/anticoagulated rabbits were comparable. In the vegetations streptococci were found mainly in areas free of phagocytic cells. It is concluded that streptococci do not have to be phagocytosed by monocytes in the circulation before being deposited on the surface of endocardial vegetations. Even the vegetations of intensively anticoagulated/monocytopenic rabbits showed colonies of streptococci embedded in polymerized fibrin and cellular material, this matrix possibly being held together by streptococcal dextran.

Animals↗
PubMed1980

Experimental Streptococcus sanguis endocarditis: immune complexes and renal involvement.

An increase of agglutinins and circulating immune complexes (CIC) was observed in the sera of rabbits after the induction of bacterial endocarditis (BE) by intravenous injection of live streptococci into animals with a non-bacterial thrombotic endocarditis. Rabbits immunized for 12 days with heat-killed streptococci developed higher levels of agglutinins and CIC than did those unimmunized during BE. The levels remained elevated in the immunized rabbits after the induction of streptococcal endocarditis. In rabbits with very high levels of CIC complement activation occurred in vivo, possibly via the classical pathway. Kidneys from both unimmunized and immunized rabbits with streptococcal endocarditis contained bacteria and also showed inflammatory reactions but only the renal tissue of immunized rabbits with endocarditis showed a little mesangial deposition of immunoglobulin. The findings in this study indicate that in rabbits, renal inflammation due to BE is initiated more often by septic emboli than by immune complex deposition, at least during the first 12 days after infection.

Agglutinins↗
PubMed1978

Renal cysts in premature children: occurrence in a family with polycystic kidney disease.

Discrete but typical renal lesions, probably representing the first stage of familial adult-type polycystic kidney disease, were found in two premature still-born daughters of a woman whose family had many cases of this autosomal dominant disease. Apparently, enough cysts were present to form polycystic kidneys of adult size solely by cyst dilation, without additional cyst formation.

Child↗
PubMed1977

Characteristics of mononuclear cell populations in chronically inflamed synovial membranes.

Mononuclear cells infiltrating synovial membranes in chronic synovitis were characterised both in situ and in cell suspensions by surface markers and histochemical techniques. T-lymphocytes were the predominant infiltrating cell in rheumatoid arthritis as well as in other forms of chronic arthritis, including ankylosing spondylitis and arthritis associated with Crohn's disease. B-lymphocytes were found exclusively in rheumatoid synovial membranes. These cells were demonstrable both in true germinal centres and, focally and diffusely, in nodular mononuclear infiltrates lacking the histochemical characteristics of germinal centres. The synovial lining cells, unlike mononuclear phagocytes, had no demonstrable receptors for C3 and Fc.

Adult↗
PubMed1977

Effect of warfarin on the induction and course of experimental Staphylococcus epidermidis endocarditis.

The effect of warfarin treatment on an experimental Staphylococcus epidermidis endocarditis was studied. Warfarin was found to affect both the induction and course of the infection of catheter-induced endocardial vegetations. In warfarin-treated rabbits, larger bacterial inocula were needed to induce an infection, and the degree of infection of the vegetations was also significantly lower, eventually resulting in the total elimination of the bacteria from the vegetations. Thus, warfarin treatment seems to have an inhibitory effect on the induction and development of an S. epidermidis infection of the endocardium. The results differ from previous findings in studies done with Streptococcus anguis, where warfarin was found to have no effect on the induction or course of the infection of endocardial vegetations, which suggests that different mechanisms are involved in the pathogenesis of endocarditis caused by these two species of bacteria.

Animals↗