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F Eisinger

Publications and source records attributed to F Eisinger.

86 records · Page 5Linked to original sources
PubMed1994

[Pilot study of screening of prostate cancer by the assay of prostate specific antigen in occupational milieu].

The goal of this study was to confirm the capacity of occupational medicine to become involved in cooperative screening programs with a dosage of the PSA (Prostate Specific Antigen) determined by immunoradiometric assay. Two thousands and five hundred seventy three salaried workers in the building sector, between 50 and 65 years old, participated in this investigation. Thirty seven individual ie 1.4% had a PSA level above or equal to 10 micrograms/l. Among them, 35 were checked within three months and 17 were found to have a persistently elevated PSA level. In this subgroup 15 pathologies including two cancers were found. We observed a great variability in the results of PSA determination in the groups of individuals whose initial assay level was above or equal to 10 micrograms/l. The linear correlation coefficient between the two assays (on the same individual), carried out at a six week interval on average, was low (r = 0.52 for N = 35). In our series, 3.5% of patients followed up had undergone a rectal examination less than a year previously. Occupational medicine seems to be an efficient setting for screening intervention. However, the people mainly concerned by our study, (salaried workers seen through the physicians interviewed) did not seem very aware of this type of action.

Adult↗
PubMed1994

[Attitude of the French female population to cancer screening].

UNLABELLED: Attitudes of the French female population towards screening of different types of cancer were studied by means of a telephone survey conducted among a random sample of the French population aged 18 to 75 (n = 2,099). MAIN RESULTS: Cancer remains the most highly feared disease among the population. This fear is more apparent among women than men (61.5% average or strong fear vs 52.6%). In addition, women are more frequently prone to disclosing cancer cases among relatives. Over the last three years, respectively 28.4% and 70.5% of the 1,075 women in the sample had undergone a mammography and a Pap smear. Results suggest that there is still a discrepancy between current screening practices and official recommendations for systematic screening policies in France, as well as a trend towards "overutilization" among younger women and insufficient coverage among older women. Women living in French administrative districts where systematic screening campaigns for breast cancer are in place, had a better access to mammography (40.5% vs 26.2% in the rest of the sample). Multidimensional analysis confirms that social isolation is related with a poor access to either type of screening, although systematic screening campaigns have helped to reduce socio-cultural inequities in access to mammography for the target population of women aged 50 to 69. This analysis also suggests that when an individual adopts some preventive behaviors (such as giving up smoking), it may have a reassuring effect which in turn discourages access to screening; therefore the need for a greater coherence in the various sectors of preventive action against cancer is advocated by the authors.

Adult↗
PubMed1994

[Genetics and cancer of the breast].

Breast carcinoma is the commonest cancer in women. Segregation analyses support the existence of a major susceptibility gene with a dominant pattern of inheritance in 4 to 10% of cases. Three genes involved in the genetic predisposition to breast tumors have recently been identified: BRCA-1 associated with early onset familial breast cancer and breast/ovarian carcinoma syndrome, p53 associated with Li-Fraumeni syndrome, and the androgen receptor gene in male breast cancer with Reinfenstein syndrome. A better understanding of inherited contribution may have important implications for screening individuals at high-risk in families.

Ataxia Telangiectasia↗
PubMed1982

[Automatic non-ambulatory measurement of arterial pressure. Computer data-analysis of the evaluation of antihypertensive treatment].

To gain a better understanding of the therapeutic effect of HTA, the present study reports a new method essentially based on the non invasive non ambulatory monitoring of blood pressure by the Dinamap 845. This apparatus was initially assayed towards the measure of invasive blood pressure and by the auscultatory method, and afterwards towards the analysis of approximately one hundred resulting data. The computer analysis of the data was performed using a microcomputer which gives the results as: time dependent curves over 24 hr; histograms, percentage of the values of HTA (above 140 mmHg for the systolic and 90 mmHg for the diastolic one); numeric data such as: average values, SEM... The method reported here appears to be convenient to follow new therapeutic treatment because the data obtained before and after treatment proved to be more rigorous and less varying upon the physician. This kind of investigation seems also helpful in the case of both hypertensive emergencies and treatment of those HTA which are difficult to stabilize. But it is thought to be not easily applied to all the hypertensions studied in the usual medical practise.

Blood Pressure Determination↗
PubMedDate not supplied

Time elapsing from cancer diagnosis and anxiety in women attending cancer genetic clinics.

The aim of this study was to investigate the effects of cancer genetic consultations on feelings of anxiety in women with breast/ovarian cancer. Among the 138 women attending six French clinics during a one-year period, 115 (83.3%) answered pre- and post-consultation questionnaires. The state anxiety score (Spielberger's STAI) was lower (paired t-test, p<0.001) after the consultation (34.7 9.4) than before (38.8 10.5). The time elapsing since cancer diagnosis (r=-0.28, p=0.007) was the main predictor of the decrease in anxiety. The patients consulting earlier after their cancer was diagnosed were more anxious before the consultation than those consulting later: whereas their anxiety states after the consultation were similar. The consultation effectively decreased the anxiety observed and the anxiety felt by cancer patients before the consultation may constitute an anticipatory stress response that should be investigated.

Anxiety↗
PubMedDate not supplied

Hypothesis: more mutations to cure cancer?

Cancer results from the accumulation of selected mutations. We propose here that some combinations of mutations may be counterselected. To illustrate this, we show an analysis of allelotyping in human breast tumors in which we demonstrate that specific associations of genetic events are statistically under-represented. This emerging concept could be used in a new therapeutical approach of cancer.

Breast Neoplasms↗
PubMedDate not supplied

PS2 expression in BRCA1-associated breast cancers.

BACKGROUND: PS2-expression is controlled by estrogens and is a prognostic factor for long-term and post-relapse survival. Breast carcinomas associated with a BRCA1 mutation (BRCA1-BC'S) exhibit many specific features, particularly for ER expression. Our purpose was to determine if pS2-expression was different in BRCA1-BC's compared with sporadic breast cancers. MATERIALS AND METHODS: We studied, by immunohistochemistry pS2-cxpression in a series of 33 BRCA1-BC's and a series of 193 sporadic cases according to many parameter including hormone receptors (ER and PR). RESULTS: In BRCA1-BC's, pS2 was expressed in only 10/33 (30.3%) carcinomas, and 4/4 (100%) ER positive: among sporadic carcinomas, 133/193 (68.9%) cases were pS2-positive, 102/127(80.37%) ER positive; the difference was significant (p<0.0001). In univariate analysis, pS2-expression was correlated with many parameters including hormonal receptor status and absence of BRCA1 mutation. In multivariate analysis, pS2-expression was still correlated with ER but no more with BRCA1 mutation. CONCLUSION: pS2-expression in BRCA1-BC's was significantly different from sporadic breast cancer (p<0.0001) and correlated in a multivariate analysis with the same factors in sporadic and BRCA1-BC's but not with BRCA1 mutation.

Breast Neoplasms↗
PubMedDate not supplied

[Results of the treatment of myeloma with a vincristine-melphalan combination].

The authors report the results obtained in a series of 20 multiple myelomas by an association Vincristin-Melphalan with a maximum therapeutic survival of 65 months. The median of survival is established at 27 months. The differences are a function of the initial values of the calcemia, the level of hemoglobin, the percentage of medullary plasmocytosis, but the essential factors appear to be the delay in the treatment, the stage of development established according to Salmon and Durie and particularly the presence or absence of a renal involvement. We have seen important fluctuations of certain immune parameters, particularly level of sheep rosettes and B cells detected by immunofluorescence.

Aged↗
PubMedDate not supplied

[Silicon, bone tissue and immunity].

The authors study the activity of a soluble salt of silicium on the evolution of the trabecular bone volume (TBV). They note a significant increase in the TBV, both in drinkable and in injectable form, in relation to a control population not receiving osteotrope medication. They moreover note, in a series of patients treated with silicium compared to a control group, a net increase in circulating lymphocytes and immunoglobulins (especially IgG).

Adult↗