Biomedical subjects
Publications and source records attributed to F E Ulrich.
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In 119 children and adolescents with restricted growth whose secretion of growth hormone (hGH) was investigated in the insulin hypoglycaemia test, different hGH-secretion patterns were found. 52.1% of the investigated persons showed a prestimulatory stress-conditioned hGH-secretion. There were no relations to age or to sex. The hypoglycaemia-conditioned secretion of hormone following this spontaneous release has quantitatively no relation to the size of the decrease of blood sugar. However, it is also determined by the trend of secretion in the pretest-phase. Different modes of synthesis and release are the cause for this behaviour. High spontaneous hGH-levels decrease the hypoglycaemia effect of the intravenously applied insulin. In 33.9% of the cases the levels of the growth hormone are lower during the proper test phase or only as high as in the preparation time. Twelve times the poststimulatory values simulated a hyposomatotropism. The eventual importance of the secretion patterns remains up to now unclear for the longitudinal growth.
About 30% of amenorrhoeic women have a disturbed prolactin secretion. In about 10% the cause is a hypophyseal-suprahypophyseal tumour. Taking into consideration the degree of severity of the galactorrhoe, the amenorrhoe is connected with incontinence of milk. Also disturbances of the male potency may with partly similar symptomatology be conditioned by a hyperprolactaemia. For the development of hypogonadism the physiologic effect of prolactin gives sufficient explanations. With the introduction of dopaminergic substances which influence the disturbed regulating circle hypothalamus-hypophysis in the sense of an inhibition of the prolactin secretion new conservative possibilities for the therapy of disturbances of fertility are the result. With adequate recommendations for the radioimmunologic determination of prolactin the WHO made allowance for the central position of prolactin in the pathogenesis of hypogonadism. In particular the existence of hypophyseal microadenomas presumes a close cooperation between gynaecologists, radiologists, ophthalmologists and endocrinologists in the clarification of hyperprolactinaemic disturbances of fertility.
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It is reported on the possibilities of the application of anti-androgenics, especially of cyproterone acetate. The indication extends to hirsutism, sexual deviations, growth disturbances in pubertas praecox as well as diseases of the prostate. Particularly strong standard are to be applied in the treatment of fertile women, as there exists the danger of an intrauterine feminisation of male foetuses, when a pregnancy was not absolutely excluded. Side-effects and results of animal experiments are mentioned. The therapeutic mechanism of the anti-androgenics can be explained with the help of a concurrency mechanism at the androgen receptor or acceptor.
72 of 413 adults and 55 of 112 children with intact function of the hypophysis revealed secretions of the growth hormone already in the preparation time for a clinical test. These variations of the HGH basal levels must be regarded as conditioned on test. In the judgment of the function of the anterior lobe of the pituitary gland with the help of the dynamics of the HGH-secretion the changes in the pretest-period should be included in order to avoid false diagnoses. From the secretion of the growth hormone conditioned on stress hitherto no conclusions can be made to the following course of the HGH-secretion.