Biomedical subjects

F Duckert

Publications and source records attributed to F Duckert.

At least 127 records · Page 7Linked to original sources

PubMed1975

[The radiofibrinogen test in differential diagnosis of fresh deep venous thrombosis].

The radio-fibrinogen test is a simple and sensitive method for diagnosing deep vein thrombosis. Intravenously administered radioactive labelled fibrinogen is incorporated as radioactive fibrin in freshly developing thrombi, and such labelled thrombi may be detected on the body surface with nuclear medical equipment. Homologous iodine 125 labelled fibrinogen is chiefly used since it is known not to transmit viral hepatitis. The weak gamma emittor 125-I allows the use of a portable scintillation detector rate meter with an easily moved measuring device. This bedside method does not involve discomfort for the patient. The correlation between ascending phlebography and the radioactive fibrinogen test is more than 90 percent. The radiofibrinogen test may be used to study thromboembolic diseases, to evaluate drugs for prevention of thromboembolic complications and to confirm clinically suspected fresh deep vein thrombi. Details of the method as used in several thousand measurements are given.

Diagnosis, Differential↗

PubMed1975

Treatment of deep vein thrombosis with streptokinase.

From September 1962 to May 1972 145 patients with acute or subacute deep vein thrombosis confirmed by phlebography were treated with streptokinase. During the same period 42 patients considered unfit for thrombolytic therapy were treated with herapin and oral anticoagulants. The results, assessed by repeat phlebography, in 93 of the patients treated with streptokinase were compared with those in 42 patients treated with heparin. The age, sex, and severity of occlusion were roughly similar in both groups. Streptokinase treatment was successful in 42 per cent, partially successful in 25 per cent, and unsuccessful in 32 per cent of the 93 patients compared with none, 10 per cent, and 88 percent respectively in the 42 patients treated with heparin. Streptokinase was more effective when the thrombus was in proximal rather than calf veins. Thrombi of more than six days old were readily lysed. Plasma fibrinogen levels were below 0-8 g/1 (80 mg/100 ml) in nearly all patients successfully treated. The incidence of pulmonary embolism was no greater with streptokinase than with heparin treatment. Only prolonged follow-up would show whether thrombolytic treatment would be effective in preventing late complications of deep vein thrombosis such as chronic venous insufficiency.

Adult↗

PubMed1975