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Biomedical subjects

F Duboeuf

Publications and source records attributed to F Duboeuf.

43 records · Page 3Linked to original sources
PubMed1990

Comparison between radial bone mineral density measured by single photon absorptiometry and histomorphometric bone mass parameters measured on iliac crest biopsies.

Bone mineral density (BMD) measured by single photon absorptiometry (SPA) with a Moolsgard 1100 device on the distal and proximal part of the radius was compared with histomorphometric parameters measured on iliac crest biopsies in 37 patients suffering from various bone disorders. In the whole population, a good correlation was observed between the cancellous bone volume (Cn-BV/TV) measured on iliac crest biopsies and BMD from both the proximal part of the radius (r = 0.76, p less than 0.001) and the distal part of the radius (r = 0.73, p less than 0.001). Significant, although weaker correlations, were also found between the cortical width and the BMD from the distal part (r = 0.37, p less than 0.001) and the proximal part (r = 0.44, p less than 0.001) of the radius. In the 14 untreated osteoporotic patients, only a significant Spearman correlation was observed between the iliac Cn-BV/TV and the proximal radial BMD (r' = 0.69, p less than 0.05). It is thus not clear, whether radial proximal BMD correctly indicates cortical bone density in osteoporotic patients or not. The large internal variability of each of the two investigated methods and the small group of osteoporotic patients might explain the lack of correlation between the two methods in this group.

Absorptiometry, Photon↗
PubMed1989

[Increase of vertebral bone density in heavy drinkers of mineral water with a high fluoride content].

The mineral density of bone (MDB) was measured by dualphoton absorptiometry in the lumbar vertebrae of 23 healthy volunteers who consumed large amounts of a mineral water with high fluoride content (8.5 mg/l). The subjects studied had ingested a minimum of 0.75 litre of this water each day for 5 years or more. None of them had a history of pain in the bones or spontaneous fracture. MDB was found to be significantly higher in these subjects than in age - and sex-matched controls, and particularly high in those who were older than 60 years. There was positive correlation (r = 0.61, p less than 0.02) between MDB and mineral water consumption index. Serum levels of osteocalcin - a marker of bone formation - and urinary fluoride levels were significantly higher in drinkers of St-Yorre water than in controls. These data suggest that prolonged consumption of this mineral water by subjects without renal impairment might protect against the risk, increasing with age, of vertebral osteoporosis.

Adult↗
PubMed1989

[Measurement of bone mineral content by quantitative digital radiography. First results in the lumbar vertebrae].

The precision of quantitative digital radiography (QDR) bone densitometer has been evaluated from measurements which were made on an anthropomorphic spine phantom of known mineral content and on volunteers. In vitro and in vivo, the coefficient of variation of the measured values was less than 0.4 p. 100 and the accuracy was very close to 100 p. 100. Measurements were also made on 30 patients and gave results that were well correlated with those obtained with two different dual photon absorptiometry (DPA) apparatus (Novo Lab 22a and Oris).

Adult↗
PubMed1988

Comparison of bone mass measured by histomorphometry on iliac biopsy and by dual photon absorptiometry of the lumbar spine.

In a prospective study we compared bone mass measured independently by dual photon absorptiometry (DPA) on lumbar spine and by histomorphometry on transiliac biopsy. Measurements were done in 83 patients (23 males, 60 females) with various generalized bone diseases, including spinal osteoporosis, primary hyperparathyroidism and osteopetrosis. Iliac bone density was analyzed on bone biopsy with an automatic image analyzer and expressed as the trabecular bone volume (TBV), the cortical thickness (CT) and the total bone density (TBD) which includes the density of both spongy and cortical bone within the periosteal envelope. The bone mineral content (BMC) and density (BMD) were measured from L2 to L4 with a Novo Lab 22a device. For the 83 patients, there were significant correlations between values given by both methods, with r values ranging from 0.74 to 0.43, according to the bone mass parameters analyzed. In the 37 patients with untreated vertebral osteoporosis, the TBV--but not the CT nor the TBD--correlated significantly with the BMD of the spine (r = 0.53, p less than 0.001). In conclusion, there is a significant correlation between bone density of the iliac crest assessed histomorphometrically and spinal density measured by DPA. Despite the fact that DPA measures both trabecular and cortical bone of the spine, it correlates better with iliac trabecular bone mass than with the overall iliac bone density.

Adolescent↗
PubMed1987

[Measurement of lumbar bone mineral density by biphoton absorptiometry. Methodology. Reproductibility. Normal values].

Measurements were made with a DPA apparatus (Novo Lab 22a) on different phantoms and on volunteers in an attempt to evaluate the system precision. The reproductibility was found in the range of 0.98 to 4.10% in the case of in vitro measurements, depending on the geometry of the phantoms used, and in the range of 1.6 to 2.94% for volunteers after repositioning. Secondly, the BMD in the lumbar spine of normal women and normal men was estimated. In control females, the BMD is well fitted to the age by a cubic regression. The maximum value of the BMD is found in this case at the age of 31.5 and the maximum rate of bone loss takes place at 57. Total bone loss between 31.5 and the elderly is about 32%. In control males, results are more scattered and are represented by a simple linear regression. The average mineral loss between 30 and 80 years is 11.5% in this area of measurement.

Adult↗
PubMedDate not supplied

[Lumbar vertebrae mineral content in women. Normal values obtained using quantitative digital radiography].

The bone mineral content of the lumbar spine was measured in 120 normal women, using quantitative digital radiography (Hologic QDR 1000). From the results obtained, expressed in g/cm2, the curve of the lumbar spine mineral density according to age was established, in order to demonstrate a maximum at 32.8 years, a minimum around 80.5 years with total mineral loss of 32.5% and a maximum speed of bone loss at 56.5 years (6 years after the average menopausal age). Moreover, from measurements in 30 osteoporotic women, the value of the fracture threshold was estimated at 0.730 g/cm2.

Adult↗