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Biomedical subjects

F Dietze

Publications and source records attributed to F Dietze.

At least 37 records · Page 2Linked to original sources
PubMed1980

[The aging of intermitotic cells (author's transl)].

The aging of the cells depends on their mitotic activity, which is particularly evident in multicellular organisms. By way of histoautoradiography we studied the cell kinetics on a total of 244 Wistar rats aged 6 days, 6 weeks, 6, 12, 23 and 28 months respectively, with these studies being centred on the mucosa of the small intestine since this mucosa is one of those tissues with the highest cell metabolism. We succeeded in demonstrating that the regeneration rate of cells per hour in the crypts of the small intestine and the migration speed of the enterocytes differ in young and old individuals and that the intermitotic cells have age-dependent properties as well. In addition, we could prove that intermitotic cells too have a non-growth fraction which, at an advanced age, decreases only a little, although significantly in terms of statistics. For the easily vulnerable crypt epithelium it is a reserve capacity and can be included in the proliferating pool, if necessary.

Animals↗
PubMed1980

[On the effect of biologically active substances (experimental studies) (author's transl)].

The influence of prolonged Procaine and Turigeran therapy on the cellular kinetics of the mucous membrane of the liver and small intestine has been studied by means of 3H-thymidine histo-autoradiography of a total of 240 12-month-old male Wistar rats. The following observations have been made: 1. The pool of DNA-synthesizing liver parenchyma cells and Kupffer's cells in the treated animals is clearly increased compared with that of the untreated controls. There is no difference between the rats treated with Procaine and those treated with Turigeran. 2. Nor does the cellular kinetics of the mucosa of the small intestine exhibit any differences between the animals treated with Procaine and those treated with Turigeran. Since, on the other hand, significant differences appear between the treated animals and the untreated controls regarding all characteristics of cellular kinetics, this effect is solely attributable to Procaine. 3. The various phases of the cellular cycle are prolonged in the treated animals, resulting in an overall delay in the generative cycle. 4. A reduced speed of migration of the cells in the region of crypts and villi finally results in the fact that in spite of the reduced rates of proliferation a greater number of labelled cells can be observed in the crypts of the treated animals (labelling index). 5. The unmitigated effect of Procaine is discernible for at least two weeks after the discontinuation of the treatment.

Animals↗
PubMed1980

[The importance of involutively conditioned and conditioned by morbidity alterations of enteral absorption and the nutrition of geriatric patients with obstructive jaundice and carcinomatous diseases (author's transl)].

In case of absorption examinations in younger and advanced age it is necessary to differentiate between involutively conditioned alterations of enteral absorption and those ones conditioned by morbidity. For this purpose the modified D-xylose-absorption test offers itself as a diagnostical remedy. The equivalently characteristic alterations in absorption kinetics of carbohydrates in cases of the occurrence of an obstructive jaundice, in patients in the stage of generalisation of carcinomatous disease and in the elderly may be demonstrated by the modified D-xylose-Test.

Aged↗
PubMed1979

[Diseases of the digestive tract in old age (author's transl)].

Diseases of the digestive tract follow a changed pattern in old age. Their particularities as well as the geriatric aspects of diagnosis and therapy are discussed. Inflammations, neoplasms and circulatory disorders in the alimentary tract are discussed, while affections of the stomach, colon and the biliary tract are described in more detail because of their frequency and the propensity to complications and increased mortality rate involved. Although the therapeutical means and methods available for elderly patients do not differ substantially from those available for younger ones, certain guiding lines should be taken into consideration. The author shows by means of examples that certain difficulties in treating old people must not be allowed to lead either to an overrealous or nihilistic attitude.

Aged↗
PubMed1979

[Investigation of the excretory function of the pancreas in later life by means of secretin and pancreozymin (author's transl)].

The investigation of the excretory function of the pancreas in subjects of various age groups has shown that digestive activity can be assessed only by means of secretin and pancreozymin. Stimulation with secretin (dose: 2 international units per kilogram of body weight of the subject) done twice within 60 minutes or a twofold combined secretin-pancreozymin test yield the most reliable data on the excretory functional capacity of the pancreas and its secretory reserve in elderly people. The data from subjects of various age groups--young, old and very old--can be used as a guideline for setting up standards for various age groups. They are also important for functional diagnosis and for differentiating between age-dependent functional changes and pathological conditions of the pancreas.

Adult↗
PubMed1978

[Digestion and absorption in elderly man (author's transl)].

Morphologically first indications of an age-related alteration of pancreatic microscopic structures can be proved an age of fourty. In healthy elderly man functional capacity of exocrine pancreas is lowered. It can be proved by means of pancreatic function tests. Normally the digestive capacity will be sufficient provided a reasonable nourishment. Usually the intestinal absorptive capacity tends to decrease in the elderly. But following delayed intestinal transit of nutritients absorption to a certain degree can occur sufficiently. Considering the nutrition of elderly people recommendations are given.

Age Factors↗
PubMed1978

[Initial results of investigations into the proliferation kinetics of enterocytes (author's transl)].

The changes of absorption appearing in man and caused by aging are probably due to disturbances of the proliferation and exfoliation kinetics of the enterocytes of the small intestine mucosa. The relevant experimental examinations available are insufficient because the results were obtained from a few animals only. Our own systematic autoradiographic examinations of rats are designed to contribute to a clarification of this problem which is important for practice.

Adolescent↗
PubMed1977

[Involutive specialities of the water-- and electrolyte metabolism (author's transl)].

The involutive restriction of the renal, pulmonary, endocrine and buffer mechanisms also diminished the range of efficacy and possibility for adaptation of the water-- and electrolyte metabolism of old people. Under geriatric aspects many causes for the endangering of the water-- and electrolyte metabolism and the therapeutic consequiences are discussed. It is founded that in old patients the quicker metabolism imbalance means a stronger threat of life that the disease itself. Often the consideration of this problem in much cases of diseases can save the life of the old patient.

Adaptation, Biological↗
PubMed1977

Peculiarities of digestion in senescence.

It is established, that involutional changes of digestive tract limits digestion in old patients. In the age digestive capacities mostly are sufficient, but there is a great tendency to maldigestion. The decrease of functional capacity doesn't show the clinical features of a manifest digestive insufficiency in old healthy probands. But it was shown that the digestive efficiency is exhausted by hyper-alimentation more quickly in elderly. The pancreas of elderly is able to digest small meals taken frequently.

Adult↗
PubMed1976

[Aging and resorption].

The enteral absorption in dependence of age has been tested by D-xylose. From the additional investigation of the D-xylose reaction in the blood plasma one can detect statistically ascertained age relation in comparison between young and old healthy test persons. Though in old age the absorption process is retarded a sufficient absorption at a longer time at diminished speed of passage of the ingesta in old age.

Adolescent↗