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Biomedical subjects

F Dienstl

Publications and source records attributed to F Dienstl.

At least 91 records · Page 5Linked to original sources

[Recurrent ventricular fibrillation (author's transl)].

106 episodes of ventricular fibrillation were observed in 11 patients, 9 of whom had acute myocardial infarctions. The heart rate before the onset of ventricular fibrillation was below 50 in two episodes, 60 to 100 in 63, and above 100 in 41. 83 attacks of ventricular fibrillation were preceded by fewer than five ventricular premature beats, 23 by more than five, 19 by more than ten. Multifocal ventricular premature beats occurred ten times, runs of ventricular premature beats 11 times, with only three falling into the vulnerable period. Left bundle branch block was present in three patients, right bundle branch block with left anterior hemiblock in two, isolated left anterior hemiblock in two, left posterior hemiblock in one. 85 episodes of ventricular fibrillation occurred during antiarrhythmic treatment, 72 during lidocaine administration. Antiarrhythmic drugs were effective only in reducing the number of ventricular premature beats. The only successful treatment of recurrent episodes of ventricular fibrillation was repeated electrical countershocks.

Aged↗

Hypoxic, isolated rat heart: hemodynamic and metabolic effects of nitroglycerin.

The purpose of the study was to evaluate the effects of nitroglycerin on the mechanical and metabolic performance of the mammalian heart without interference from peripheral vascular and neurohumoral influences. Isolated rat hearts were perfused with a buffer containing 1 mug of alcoholic nitroglycerin/ml or an equivalent amount of alcohol. Mechanical performance was analyzed during external and isovolumic work; all hearts were subjected to mild hypoxia. Heart rate was kept constant by pacing. At constant atrial filling pressures end diastolic pressures and calculated wall stiffness were not significantly different for controls and nitroglycerin. Afterload, as quantitated by mean aortic pressure, was the same for both groups. Peak-systolic left ventricular pressure and dp/dt max during ejection and isovolumic work were significantly reduced by hypoxia (p less than 0.001), but not changed by nitroglycerin. Cardiac output, mean systolic left ventricular pressure, work, oxygen consumption, and calculated efficiency were decreased by hypoxia (p less than 0.001); lactate production was enhanced by the hypoxic state (p less than 0.001). Nitroglycerin had no influence on these parameters in either state. It is concluded that at constant rate, preload and afterload nitroglycerin has no effect on the mechanical performance and energy formation by aerobic and anaerobic means in the fully oxygenated and mild hypoxic state.

Animals↗