[Alpha fetoproteins and fibrinogen degradation products (FDP) in amniotic fluid].
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Biomedical subjects
Publications and source records attributed to F Diani.
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Premature rupture of membranes and intrauterine growth retardation are the most frequent conditions in which preterm labour and delivery may be facilitated or induced. If the membranes ruptured before 34 weeks, pregnancy may be prolonged for more than one week and premature fetus perhaps might benefit of steroid administration for the prevention of respiratory distress syndrome and of antibiotic preventive treatment. After 33 completed weeks no prolongation of gestation for more than one week seems to be particularly useful for newborn survival. Actually, intrauterine growth retardation and fetal chronic distress may be prematurely diagnosed (sonographic and Doppler diagnosis, non stress test, ecc.). Antepartum fetal evaluation and management of pregnancy with poor intrauterine growth are problems that need multidisciplinary measures, but the timing and the modality of delivery are strictly obstetric decisions. In case of fetal malformations and/or in case of extremely premature low-weight infants, management and timing of preterm labour and delivery need a particular care in observance of the well-being and of the outcome of these babies.
Some considerations about an individual experience of labour and delivery care by means of three different partograms at the university departments of Obstetrics and Gynecology of Genova, Trieste and Verona are reported. The value of partography in management of labour was stressed in connection with a better delivery care, with a systematic recording of cervicometric data and fetal maternal monitoring and in the prevention of the use of unsuitable medical and surgical treatments. The partogram is also essential for the correct communication and makes both tracking and data filing easier. By means of partography the return concept of personalized care of woman in labour is possible without that safety and technology of new obstetrics are lost.
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While our understanding of Group B Streptococcal infections has progressed with impressive measure, their prevention has not been accompanied by an effective means. Chemoprophylaxis for selected colonized women at rupture of membranes or at onset of labour, enhances benefit and minimizes adverse effects. Two or more maternal risk factors are special circumstances for routine use of chemoprophylaxis in asymptomatic neonates. Immunoprophylaxis by IgG antibodies directed against the type-specific polysaccharide antigen of GBS may be provided by passive or active immunization. Hyperimmune i.v. globulins or vaccination of adult women with low levels of antibodies in their sera have been demonstrate to be protective in vivo.