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Biomedical subjects

F Despert

Publications and source records attributed to F Despert.

49 records · Page 3Linked to original sources
PubMed1981

[Juvenile and familial amyotrophic lateral sclerosis. 2 case reports (author's transl)].

The case report of two brothers who evidenced neurological disorders with peripheral nerve syndrome, pyramidal deficit and bulbar symptoms is described. The diagnosis of amyotrophic lateral sclerosis was assumed upon the association of these clinical features. Seven and nine years respectively after the beginning of the disease, an increase of the clinical features was noticed in the 2 children, more pronounced in the second one. The possibility of true juvenile and familial amyotrophic lateral sclerosis is discussed in this study; different aspects of this disease are described. A final classification of these 2 cases will not be possible until histological features are available.

Amyotrophic Lateral Sclerosis↗
PubMed1979

[Lipidic myopathy with severe cardiomyopathy caused by a generalized carnitine deficiency. Favourable course during carnitine hydrochloride treatment].

The case of a girl who presented with gastrointestinal upsets with nausea, vomiting and occasional hypoglycaemic attacks during childhood is reported. At about 5 years of age generalised muscular weakness with severe amyotrophy, cardiomegaly with a cardiothoracic ratio of 0,63, left ventricular hypertrophy on electrocardiography and left ventricular dilatation with hypokinesis on echocardiography were observed. A few weeks later she developed severe cardiac failure. Muscle biopsy showed muscular dystrophy with lipid infiltration due to carnitine deficiency )serum carnitine 9 nmoles/ml, normal values: 46 +/- 6,9 nmoles/ml; muscle carnitine 0,27 nmoles/mg, normal values: 3,0 +/- 0,79 nmoles/mg fresh frozen weight). She improved rapidly with carnitine chlorhydrate and a diet low in lipids and high in medium chain triglycerides. Regression of muscular symptoms and cardiac failure was observed. After 13 months follow-up with no tonicardiac therapy she is much improved; the signs of heart failure have disappeared, the cardiothoracic ratio is now 0,55 and the electrocardiogramme and echocardiogramme are normal.

Biopsy↗
PubMed1977

[The identification of hepatitis A virus in faeces. Diagnosis and epidemiological value (author's transl)].

During 1976, two hepatitis A epidemics in institutions enabled the authors to study the presence of the virus in the faeces during the course of the disease. After concentration of feacal extracts in polyethyleneglycol 6000, virions were observed by immune electron microscopy. Among 13 stool extracts examined, 11 proved positive. The two negative extracts were samples collected one month after the onset of clinical symptoms and signs. The samples richest in particles were those collected during the preicteric phase of the disease. In those cases in which samples were collected during jaundice, the viral concentration was lower. The limit of detection was a period of five days after the onset of jaundice. Thus, examination for hepatitis A virus in the faeces by electron microscopy may be used to obtain an aetiological diagnosis at the beginning of the disease. In one of the patients, a study of the kinetics of the appearance of antibodies was possible. From the time of onset of jaundice, the presence of specific antibodies was noted, reaching a maximum after two months. In the children's institution, no cases of hepatitis A were seen among those entrants who had received an injection of standard polyvalent gammaglobulin at the time of admission.

Adult↗
PubMedDate not supplied

[Childhood diabetes].

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Age Factors↗