Transmission of human hepatitis to marmosets: further coded studies.
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Biomedical subjects
Publications and source records attributed to F Deinhardt.
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Counter-immunoelectrophoresis was used for the quantitation of group-specific antigen and antibodies of C-type ribonucleic acid leukemia and sarcoma viruses.
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Two newborn marmosets, inoculated with a cell-free extract of feline fibrosarcomas, developed multiple sarcomas and died within 46 days of inoculation, whereas two of these animals inoculated with a crude homogenate developed no tumors. This susceptibility to a mammalian RNA sarcoma virus suggests that marmosets may be particularly suitable for attempts to isolate infectious agents from man.
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Marmosets inoculated with plasma from three early acute hepatitis patients developed hepatitis 30 to 40 days later. Other groups of marmosets receiving preinfection plasmas from the same patients showed no evidence of hepatitis in this experiment. It is, therefore, most probable that hepatitis in marmosets represented transmission of human disease rather than activation of latent "marmoset hepatitis."
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