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Biomedical subjects

F Dauchy

Publications and source records attributed to F Dauchy.

At least 19 recordsLinked to original sources
PubMed1992

Effect of pyridoxine on mice gastric ulcers and brain catecholamines after an immobilization stress.

Fifty adult female Swiss albino mice were injected with either 1.11 mg/kg body weight pyridoxine or saline, subsequently they were all submitted to an immobilization stress with a complete fast for 17 h. At the end of this period, the animals were sacrificed, the gastric mucosa was dissected for ulcer count, and brain noradrenaline, dopamine and serotonin were determined by liquid chromatography. In addition, 26 nonstressed mice were used as controls, 16 of them being fed at libitum and 10 submitted to the same fasting period as the first two groups. In the stressed animals, the average number of gastric ulcers per mouse was twice as large in the saline-treated group than in the pyridoxine-treated group (p < 0.05). With a single exception, no ulcer was found in the non stressed controls. Brain norepinephrine content was almost identical in fasting controls and in stressed mice treated with pyridoxine; in the stressed animals treated with saline, the average norepinephrine content was higher by 15% and in the fed controls lower by 11% than in the two preceding groups. Pyridoxine treatment entailed a very significant reduction (p < 0.002) of norepinephrine variability, mainly due to the absence of high values (> or = 750 ng/g of fresh brain) which occurred only in the saline-treated group. Similar results were yielded for brain dopamine. No variations were observed for brain serotonin. These results suggest the antistress effect of pyridoxine.

Animals↗
PubMed1989

Ketone bodies do not give falsely positive alcohol tests.

Ketosis, as observed in diabetic ketoacidosis or secondary to hypoglycaemia, may be associated with symptoms resembling those of acute alcoholism. It is thus essential to rule out the possibility that ketone bodies cross-react with any method of ethanol determination. Two currently used methods for detecting ethanol in the expired air (Alcotest and a fuel cell electrode), and three methods for blood determination (the nitrochromic method, gas liquid chromatography, and the TDX-REA method) were examined. No cross-reaction was found in nine grossly ketotic diabetic subjects. In vitro 3-hydroxybutyrate, acetoacetate or acetone, alone (30 mmol l-1) or in association, did not cross-react in the assays studied.

Chromatography, Gas↗
PubMed1989

[Uncommon collapse].

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Adrenal Gland Neoplasms↗
PubMed1988

[Do imipenem and cilastatin interfere with the determination of serum creatinine?].

Some cephalosporin antibiotics increase the concentration of serum creatinine. This phenomenon could be due to the interference on the method of dosage, in particularly when the Jaffé reaction is used. This interaction could be present with imipenem, an antibiotic of thienamycins group having a chemical structure similar to that of cephalosporins, (associated with cilastatin in the tienam), in which we find the structure common to creatinine (Formula: see text) considered to be responsible of this interference. Our work indicates that with serum concentration of 100 mg/l, superior to those obtained in therapeutic, neither imipenem nor cilastatin interact on the creatinine dosage using either the Jaffé reaction of the enzymatic technic.

Autoanalysis↗
PubMed1979

[Coronary by-pass operations in diabetic and non-diabetic patients with angina. Results of 102 coronary arteriographies (author's transl)].

The results of coronary arteriography were compared in 102 patients (55 non-diabetics and 47 diabetics) with angina. The lesions noted an arteriography were more severe in the diabetic patients: more frequent stenosis in the common trunk and three branches, and present in greater numbers (more than 4 in more than a half of the patients), with only a moderate proximal bed in 65% of the cases. By-pass operations can only be performed, therefore, in 32% of these patients as against 54% for the non-diabetic anginal patients. The operative risk also appears to be increased (1 death and 6 complications in 10 by-pass operations). It was also demonstrated that with similar lesions of the common trunk, the diabetics have radiological signs of a greater incidence of cardiomegaly and generalized hypokinesia of the left ventricle than non-diabetics. By-pass operations are impossible in about 85% of patients because of ischemic signs or evidence of necrosis in the ECG recordings of diabetic patients with angina.

Adult↗
PubMed1969

[Amylase].

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Amylases↗
PubMedDate not supplied

Lack of detectable deleterious effects on metabolic control of daily fructose ingestion for 2 mo in NIDDM patients.

The effects of a daily intake of 30 g fructose on blood glucose regulation, erythrocyte insulin receptors, and lipid metabolism have been studied in type II (non-insulin-dependent) diabetic subjects. Eight well-controlled patients received, in a randomly assigned crossover design over two 2-mo study periods, 30 g of fructose in exchange for an isocaloric amount of starch. Fructose could be taken at any time during the day as part of the 1400-1600 kcal allowed diet (50% carbohydrate, 30% fat, 20% protein). No significant difference was observed concerning body weight, HbA1c, fasting plasma glucose, fasting plasma insulin, uric acid, total cholesterol, high-density lipoprotein cholesterol, and triglycerides, nor was there any change in insulin binding to erythrocytes between the fructose and the control starch period. However, the mean plasma triglyceride levels after the fructose period, although still in the normal range, were significantly higher than baseline values (P less than .05). We conclude that moderate amounts of fructose incorporated into the diet of well-controlled type II diabetic subjects have no significant deleterious effect on glycemic control, insulin receptors of erythrocytes, or lipid metabolism.

Blood Glucose↗