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Biomedical subjects

F D Rose

Publications and source records attributed to F D Rose.

At least 19 recordsLinked to original sources
PubMed1998

Social and behavioural effects of traumatic brain injury in children.

Traumatic brain injury (TBI) is the leading cause of death and permanent disability in children and adolescents. Although cognitive and behavioural effects have now been reported for all degrees of TBI severity in children, other aspects of functioning which might be related (such as psychosocial adjustment), have been neglected. In the present study the social and behavioural effects of TBI were assessed by comparing 27 TBI children with 27 controls. TBI children demonstrated significantly lower levels of self-esteem and adaptive behaviour, and higher levels of loneliness, maladaptive behaviour and aggressive/antisocial behaviour. These findings confirm the previously demonstrated detrimental effects of TBI on children's behavioural functioning and offer new evidence for the detrimental effects of TBI on children's social functioning.

Adaptation, Psychological↗
PubMed1998

Virtual reality: a new prosthesis for brain injury rehabilitation.

Virtual Reality (VR) technology is a relatively new application to rehabilitation medicine, yet it offers considerable potential to achieve significant successes in assessment, treatment and improved outcome, thereby increasing our knowledge of neuroplasticity. The capabilities of VR are especially evident in neurological rehabilitation, where cognitive and behavioural problems often interact with physical impairments to reduce the overall level of functioning and interaction. The need for effective interventions in neurological rehabilitation demands communication and collaboration between disciplines. This paper presents some of the current areas of the clinical applications of VR, emphasising the link between experimental evidence on recovery after brain damage and the clinical problems encountered in a ward setting.

Brain Injuries↗
PubMed1997

Virtual environments in neuropsychological assessment and rehabilitation.

Brain damage constitutes a major problem for those affected, for their families and friends and for society as a whole. The need for effective rehabilitation strategies is clear. Yet, until the early 1960s, the brain was generally considered to be a somewhat fixed and inflexible organ. In consequence the impairments associated with brain damage were generally regarded as "incurable". Since that time neuroscientists have had reason to change their views dramatically. However, much remains to be done. Progress depends upon a co-ordinated multidisciplinary approach within which assistive technology will be a key player. Within the area of assistive technology, one of the developments which holds particular promise for the field of neurological rehabilitation is the computer technology underlying virtual environments (commonly known as virtual reality). In this chapter we describe the new opportunities offered by virtual reality to pursue several aspects of the rehabilitation process. The value of the technology of virtual environments in this context is that it allows us to immerse people with brain damage in relatively realistic interactive environments which, because of their patterns of impairment, would otherwise be unavailable to them.

Computer Graphics↗
PubMed1996

Age and recovery from brain injury: clinical opinions and experimental evidence.

For many years the notion that brain damage causes less impairment in children than in adults (sometimes known as the 'Kennard Principle') has enjoyed widespread support among scientists and clinicians. More recently neuroscientists have questioned the Principle, most now taking an opposing view that damage to the rapidly developing brain can be more harmful than equivalent damage in adulthood. Many clinicians, however, appear reluctant to reject the Kennard Principle. This study investigates the extent to which the Kennard Principle still guides the judgement of different groups of health-care professionals (neurosurgeons, neurologists, neuropsychologists, general practitioners, nurses, physiotherapists, occupational therapists, and speech therapists). Subjects were asked to estimate the extent of recovery in clinically based but fictitious case studies which differed only in the reported age of the patient. The professions differed in their levels of optimism regarding the extent of recovery to be expected, but all predicted better recovery in younger patients (under 10) than in adults with otherwise similar brain injuries. The results are discussed in terms of their implications for the treatment of brain injuries in the young.

Adult↗
PubMed1996

Virtual reality: an assistive technology in neurological rehabilitation.

The need for improved neurological rehabilitation strategies is self-evident. Recent developments in the computer technology of virtual reality hold the promise of exciting progress in this area. In this paper four areas of potential application of virtual reality to neurological rehabilitation are reviewed.

Activities of Daily Living↗
PubMed1995

Pain and pain tolerance in professional ballet dancers.

Pain experience in sport had been the subject of increasing research in recent years. While sports professionals have generally been found to have higher pain thresholds than control subjects the reasons for this are not entirely clear. The present study seeks to investigate one possible explanatory factor, the importance of the popular image of the physical activity and of the self-image of its participants, by examining pain experience in professional ballet dancers. Like sports professionals, dancers were found to have higher pain and pain tolerance thresholds than age matched controls in the Cold Pressor Test. However, they also reported a more acute experience of the sensory aspects of the pain. Explanations of this apparent paradox are discussed both in terms of the neuroticism scores of the two groups and in terms of the dancers' greater experience of pain and its relationship with physical activity. The results illustrated the importance of using multidimensional measures of pain in this type of investigation.

Adolescent↗
PubMed1993

Environmental enrichment following brain damage: an aid to recovery or compensation?

Postoperative environmental enrichment (EC) in rats with brain lesions has been hailed as a potential agent of recovery of function following brain damage. However, most such claims are based on examining the effects of EC on acquisition of a new task following brain injury. Elsewhere we have argued that since this paradigm fails to establish a preoperative behavioural baseline against which to compare subsequent performance it may demonstrate compensation but cannot provide evidence of recovery. The present study directly addresses this issue by examining the effects of postoperative EC both on performance of a preoperatively acquired water maze escape response as well as on de novo acquisition of such a response in rats with bilateral occipital and sham lesions. In terms of swim times postoperative EC was found to significantly improve the performance of subjects which had not been preoperatively trained but not the performance of those subjects which had. However, in terms of a trials to criterion measure postoperative EC benefitted animals in both the preoperative and postoperative training conditions. The results, therefore, support the view that what has been observed in most previous studies is EC-induced compensation rather than recovery and also help to define the conditions under which this occurs. However, they also argue for further investigation of the hypothesis that postoperative EC may enhance recovery of lesion-impaired performance consistency.

Animals↗
PubMed1993

Patient-controlled analgesia: a new method for old.

Patient-controlled analgesia (PCA) has successfully made the transition from a research tool for the investigation of pain, to a wider clinical utility as method of pain control. Reliable and sophisticated PCA systems have been commercially available for some time. The technique has been most commonly used for control of postoperative pain, but has also been successfully used during labour, after burns, in acute painful medical conditions and in terminal care. It is generally more effective than the traditional methods of postoperative pain control but not automatically so. The choice of opioid, the settings chosen for demand dose and the lockout interval will greatly influence the effectiveness of this method of analgesia. Psychological variables are also important in predicting the efficacy of PCA.

Adaptation, Psychological↗
PubMed1993

How does environmental enrichment aid performance following cortical injury in the rat?

Understanding how postoperative environmental brain damage in animals may help in devising treatment regimes for brain injured humans. This study tests Finger's hypothesis that EC increases the animal's ability to switch to alternative cues when brain damage renders the cues normally used in performing the task less salient or unavailable. Following preoperative water maze training to visual cues, rats were given either bilateral occipital lesions or sham operations, housed in either EC or standard conditions and then tested in the water maze in alternating visual and non-visual cue conditions. We found no evidence that postoperative EC helped lesioned rats to switch to non-visual cues when visual cues were unavailable.

Acclimatization↗
PubMed1992

Maternal hypothyroxinemia and brain development: II. Biochemical, metabolic and behavioural correlates.

Using a rat model, we have investigated the influence of maternal hypothyroxinemia throughout pregnancy on brain development in young and adult progeny. Although no consistent change was observed in whole brain total protein concentration, the subcellular distribution of protein was adversely affected. Isolation of glycoprotein from developing brain by concanavalin A-affinity chromatography and subsequent resolution by gel electrophoresis revealed the selective compromise of particular glycoprotein species. Furthermore, both control and experimental progeny expressed unique glycoprotein species which either persisted over the period studied or were transient. Calcineurin, a regulator of neurite elongation, was compromised in young progeny, as were a number of lysosomal enzymes (beta-D-glucosidase and aryl sulphatase). In adult progeny, the content of cerebroside sulphate (a major myelin galactolipid) was reduced in midbrain and paleocortex, and brain region-specific compromise was observed for acetylcholine metabolic enzymes. These changes were associated with alterations in behavioural output. We conclude that the availability of maternal thyroxine to the fetus may be a critical determinant for normal brain development and function.

Animals↗
PubMed1991

Ethnic differences in the experience of pain.

Investigations of ethnic differences in pain experience have been largely confined to the hospital or laboratory. Such studies are limited by the potentially confounding effects of the expectation of pain in the former and of little or no pain in the latter. The present investigation overcomes some of these methodological problems by studying ethnic differences in pain experience following ear-piercing. Afro-West Indian, Anglo-Saxon and Asian subjects (n = 84) completed a pain questionnaire and two rating scales after ear-piercing. Half the subjects were told the study was about pain and half that it was concerned with sensation. There were highly significant ethnic differences in pain ratings. The pain condition produced higher ratings than the sensation condition but there were no significant sex differences. The results are discussed in the context of subjects' ratings of their parents' attitudes to minor injury and their own ability to cope with pain. It is argued that investigation of the bases of ethnic differences in pain experience is important in order to develop maximally efficient pain control regimes for all sections of the populations.

Adaptation, Psychological↗
PubMed1988

Environmental enrichment and recovery from a complex Go/No-Go reversal deficit in rats following large unilateral neocortical lesions.

Postoperative environmental enrichment in brain-lesioned rats has been found to enhance performance in tasks in which a range of sensory cues can be utilized but not in tasks in which information from one particular sensory modality is essential to goal attainment. This has generally been construed as evidence of a role for environmental enrichment in facilitating compensation for sensory loss but not recovery of lost function per se. However, most published investigations have adopted an experimental design which fails to empirically separate the processes of recovery and compensation. The present investigation, by employing a unisensory task and using unilateral cortical lesions, thus markedly reducing the functional value of compensatory mechanisms in the mediation of postoperative behaviour, seeks to distinguish the contributions of these processes. The results show a sizeable hemidecorticate deficit on a visual operant Go/No-go reversal task but fail to provide clear evidence of any facilitation of functional recovery as a result of postoperative environmental enrichment.

Animals↗
PubMed1987

Transfer of effects from environmentally enriched and impoverished female rats to future offspring.

The effects of environmental enrichment on both brain and behaviour have been the subject of systematic investigation for more than two decades. However, scant attention has been paid to the possible effects on offspring of environmental enrichment of the parental generation. Experiments are described which demonstrate that manipulation of the environments of female rats even prior to pregnancy can significantly modify the behaviour of future offspring. The importance of the investigation of the mechanisms mediating this inter generation transfer is discussed in the context of recent interest in clinical applications of environmental enrichment research.

Animals↗
PubMed1987

Environmental enrichment and recovery from contralateral sensory neglect in rats with large unilateral neocortical lesions.

Previous investigations of the potential value of postoperative environmental enrichment in enhancing functional recovery in brain-lesioned rats have yielded contradictory results. The present study sought to resolve some of the contradictions by drawing a clear distinction between the contribution of environmental enrichment to the processes of compensation for sensory loss and recovery per se. By using unilateral lesions, thus avoiding total loss in any sensory modality, and examining a behavioural deficit not anyway thought to be, primarily, a consequence of sensory loss, it was hoped to arrive at an experimental test in which reinstatement of preoperative performance would necessarily reflect recovery rather than compensation. Recovery from the effects of large unilateral neocortical removals on performance on the 'bracelets' test, recently proposed by Schallert and Whishaw, Behavioural Neuroscience, 1984, 98: 518-540, as a model of simultaneous extinction in humans, was investigated. Lesions significantly impaired bracelet removal from the contralateral paw and a degree of recovery from this impairment was observed. However, recovery was not enhanced by postoperative environmental enrichment. The reasons for this were discussed and possible explanations of the recovery that did occur were considered. Implications for Schallert and Whishaw's model were also discussed. It was concluded that the present results were consistent with the view that any restorative value that postoperative environmental enrichment may have lies in facilitating compensation rather than recovery.

Animals↗
PubMed1986

Differential reinforcement effects in rats reared in enriched and impoverished environments.

Comparison of the effects of environmental enrichment (EC) and impoverishment (IC) on learning in the rat is hindered by difficulty in distinguishing, experimentally, EC/IC differences in learning capacity per se from differences in performance-related variables such as sensory or motor ability, activity and motivation. Experiments are described which analyse EC/IC performance differences in a simple lever-press training procedure. In particular the hypothesis that EC and IC rats may be differentially reinforced by the same response-contingent events is examined. The data firmly support this hypothesis and possible explanations of the differential reinforcement effect are examined.

Animals↗
PubMed1985

Doppler shift radar monitoring of activity of rats in a behavioural test situation.

The present study investigates the use of an activity monitoring system based upon Doppler shift radar for monitoring general activity of rats in a standard open field test situation. Significant positive correlations were found between the radar activity counts and the conventional lines crossed measure of activity. On the basis of these correlations it is suggested that this method of activity monitoring might be used in conjunction with other behavioural test situations. Further potential benefits of this activity monitoring system are discussed.

Animals↗