Whither infectious diseases, continued.
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Biomedical subjects
Publications and source records attributed to F D Pien.
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Between Dec 8, 1982, and Jan 29, 1983, four cases of primary bacteremia with Ewingella americana occurred in the intensive care unit of a community hospital. The patients developed high fever and leukocytosis, which gradually resolved after institution of antibiotic therapy. All infected patients had undergone either cardiovascular or peripheral vascular surgery. Epidemiologic investigation revealed that the probable source for the Ewingella outbreak was contamination of the ice bath used to cool syringes for cardiac output determinations. The nosocomial outbreak was terminated by the introduction of a closed cardiac output injectate delivery system.
Salmonella dublin infection is usually a veterinary disease. However, human outbreaks have occurred, mostly following consumption of contaminated raw milk. Salmonella dublin has a predilection for the immunocompromised host and usually causes a severe illness with fever, diarrhea, and bacteremia.
In this report we present clinical descriptions of 12 Hawaiian patients from whom Escherichia vulneris or E. hermannii strains were isolated. All but two patients had soft-tissue infections with multiple bacteria, particularly Staphylococcus aureus. The other two had purulent conjunctivitis associated with S. aureus and infected malignant peritonitis with multiple organisms, respectively. In none of the cases were the Escherichia spp. found in abundant quantities or considered pathogenic. In preliminary animal pathogenicity studies, 12 strains each of E. vulneris and E. hermannii failed to cause serious symptoms in 4-week-old mice when 10(7) cells were injected intraperitoneally. When 10(6) cells were used, none of these bacterial strains injected into mouse soft tissue was capable of producing persistent wound infections. Susceptibility studies of 40 strains of these bacteria to 20 different antimicrobial agents showed that they were susceptible to third-generation cephalosporins as well as to most other cephalosporins, aminoglycosides, trimethoprim, and sulfamethoxazole-trimethoprim; these strains were only marginally susceptible or resistant to penicillin, tetracycline, chloramphenicol, and nitrofurantoin.
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Aerococcus viridans organisms are gram-positive cocci with a strong tendency to form tetrads. These bacteria have infrequently been encountered as a human pathogen, particularly in bacterial endocarditis. A review of the literature suggests that treatment of A. viridans endocarditis should be similar to that for endocarditis caused by penicillin-susceptible streptococci.
The incidence of Campylobacter jejuni in patients with acute diarrhoea was studied in Honolulu, Hawaii. C. jejuni was recovered from 8.7% of diarrhoeal stools, compared to isolation rates of 4.2% for Salmonella and 3.8% for Shigella. C. jejuni occurred mainly in the summer and autumn, and in all age and racial groups. There was a significantly higher incidence of abdominal pain, fever history, bloody stools and faecal leucocytes in patients with Campylobacter enteritis.
Bacteriologic and clinical features of 28 cases of traumatic marine injuries are described. The most common bacterial isolates were normal skin bacteria, Staphylococcus aureus and, in 11% of cases, Vibrio alginolyticus. All injuries responded to local wound care, and only half received antibiotic therapy.
Ninety cases of closed drainage urinary catheterization were studied by daily bacteriologic monitoring with Microstix. In 23 per cent of the patients bacteriuria developed, and 92.6 per cent of all catheter infections occurred within three days. These infections occurred primarily in postsurgical patients, and were probably related to initial contamination during catheter insertion. Only 1 patient had a positive drainage bag urine culture prior to the development of bladder bacteriuria. At our institution poor catheter technique was much more important as a risk factor of nosocomial urinary tract infection than an antiseptic drainage bag system.
Serratia ficaria was isolated from culture of a leg ulcer of a 44-year-old woman who had venous insufficiency and alcoholic cirrhosis. Although Pseudomonas maltophilia, P acidovorans, and Enterobacter cloacae were also present, S ficaria was isolated in large numbers and was considered to contribute significantly to this infection. This represents the third known clinical isolation of this bacterium.
A total of 88 patients were enrolled in a double-blind comparison of cefaclor and amoxicillin-clavulanic acid for the outpatient treatment of soft tissue infections (abscesses, cellulitis, and impetigo). In 84 clinically evaluable patients, high cure rates were obtained for all treatment groups (64 to 85%). Patients who received amoxicillin-clavulanic acid had a much higher incidence of gastrointestinal side effects than did patients who received cefaclor (34 versus 3%, P less than 0.005). However, only five patients with gastrointestinal reactions to amoxicillin-clavulanic acid had symptoms severe enough to warrant halting the completion of antibiotic therapy.
Ewingella americana and a Pseudomonas species were isolated from three sets of blood cultures from a 41-year-old patient after coronary bypass surgery. This is the first well-described case of bacteremia due to E. americana. Based on data from 31 strains, a detailed description of E. americana is given.
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A homosexual man presented with a persistent high fever and a pruritic maculopapular eruption. All symptoms abated following penicillin treatment. Physicians should be aware that syphilis may present as a fever of unknown origin.
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Acute epiglottis due to Klebsiella pneumoniae in an adult patient is described. The patient failed to respond to ampicillin and required cephalosporin therapy as well as surgical drainage. In view of increased resistance of Hemophilus influenzae to ampicillin and because of other possible etiologic agents such as Staphylococcus aureus and non-Hemophilus gram-negative rods, consideration should be given for the initial use of one of the recently introduced cephalosporins such as moxalactam or cefamandole in the treatment of adult epiglottitis.
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