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Biomedical subjects

F D Hart

Publications and source records attributed to F D Hart.

At least 55 records · Page 3Linked to original sources
PubMed1977

Presentation of rheumatoid arthritis and its relation to prognosis.

A review of published reports in an attempt to relate the way rheumatoid arthritis presents to its manner of progression and prognosis has provided few positive answers. Certain, but not all, studies indicate that cases with an acute explosive onset do better than those of more insidious onset, but the latter have almost certainly lasted longer by the time they come under medical supervision. Cases of monarthritis and palindromic (remittent) arthritis do better than polyarthritic and persistent cases, but true diagnosis of the former is often uncertain. Undoubtedly persistent high-titre seropositivity and nodule formation are bad prognostic pointers. A plea is made for a more intensive study of the early case: if any therapeutic agent now or in the future can reverse the inflammatory process this is surely the time it is most likely to do so. This is the curable end of what is now an incurable disease.

Adult↗
PubMed1977

Reumatoid arthritis in Iraq.

Altogether 198 patients (149 female and 49 male) with rheumatoid arthritis, 133 classical and 65 definite by A.R.A. diagnostic criteria, have been studied in Baghdad. The disease pattern and the joint distribution are similar to those in Europe but the disease appears to be generally less destructive; hands are involved more often than the feet, and rheumatoid nodules, severe systemic upset and extra-articular manifestations appear to be less common.

Adolescent↗
PubMed1976

Which antirheumatic drug?

Successful therapy in a chronic rheumatic disease means choosing the right drug for the right patient with the right condition at the right time. In the treatment of gout three different types of treatment are given: for the acute episode, suppression and long-term therapy. Misuse of long-term therapy for acute gout will often aggravate the condition. As regards rheumatoid arthritis, in the absence of a known aetiology, treatment is essentially empirical and palliative; the use of milder well-tolerated anti-inflammatory agents for the less severe cases, more effective and more toxic agents for the more severe cases, and slow acting long-term agents for those not responding to previous measures is discussed. Night pain and morning stiffness has its own therapy. The place of corticosteroids throughout the whole field of rheumatology is evaluated. In the treatment of systemic lupus erythematosus corticosteroids still hold first place, but the cytotoxic (immunosuppressive) agents also play a part, though an arguable one.

Adrenal Cortex Hormones↗
PubMed1976

The use of psychotropic drugs in rheumatology.

The possible role of various psychotropic drugs in the management of rheumatic diseases is considered--tranquillizers, sedatives, tricyclic antidepressants and monoamine oxidase inhibitors. The dilemma of which anti-depressant for which patient is considered. The possible association between rheumatoid disease and disorders of the brain, brain-stem and autonomic nervous system is discussed. Psychotropic drugs may effect the disease itself as well as the patient's mood. The author is opposed, however, to the idea that rheumatoid arthritis may be regarded as a psychosomatic disease.

Anti-Anxiety Agents↗
PubMed1975

A double-blind cross-over trial of Prenazone (DA 2370) and phenylbutazone in rheumatoid arthritis.

A short-term double-bind cross-over trial of prenazone 600 mg daily and phenylbutazone 300 mg daily was carried out in twenty out-patients with rheumatoid arthritis. Ten patients preferred prenazone, and eight preferred phenylbutazone. No significant difference in analgesic and antiinflammatory potency was demonstrated under the conditions of the trial, and no serious adverse effects, either clinical or laboratory, were encountered. These findings support other claims that prenazone may be a useful alternative in the treatment of rheumatoid arthritis.

Aged↗