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Biomedical subjects

F Cuccurullo

Publications and source records attributed to F Cuccurullo.

At least 145 records · Page 8Linked to original sources
PubMed1980

[Cardiac metabolism in angina patients before and after aorto-coronary bypass].

The haemodynamic indices proposed by Buckberg et al. have been used to evaluate total coronary flow and its distribution to the subendocardial tissue. The following conclusions were drawn from the data obtained in humans and in experimental pathology: 1) in regional ischaemia (angina, myocardial infarction), the DPTI/TTI ratio expresses the degree of subendocardial hypoperfusion with fair approximation, although it has some theoretical limitations, 2) in total myocardial ischaemia, as occurs during ECC, the index provides an accurate picture of the subendocardium and a useful idea of the real effectiveness of the means of myocardial protection.

Angina Pectoris↗
PubMed1979

Effects of indomethacin on postural hypotension in Parkinsonism.

A study was conducted to evaluate the effect of indomethacin on orthostatic hypotension in Parkinsonism. Twelve elderly patients participated and the drug was given in two-ways--as an intravenous infusion of 50 mg over 30 minutes and by mouth 50 mg thrice daily for six days. Results were assessed by measuring the degree of hypotension on standing, response to the cold pressor test, and forearm blood flow (by strain-gauge plethysmography). Indomethacin significantly reduced the fall in blood pressure on standing (P less than 0:001) and lessened or reversed orthostatic symptoms. Furthermore, there was an enhanced response to the cold pressor test and a reduction in forearm blood flow. These findings suggest that indomethacin has a positive effect on systemic vascular resistance.

Administration, Oral↗
PubMed1979

Study of the metabolic effects of bunitrolol (Koe 1366) in angina induced by catecholamine infusion.

In ten angina patients responding with a myocardial anaerobic metabolic pattern to isoproterenol infusion, a new beta-blocking agent, bunitrolol, was effective in normalizing the myocardial lactate extraction ratio. The correlation with lipid metabolism was also interesting because beta-blocker action reduced significantly arterial non-esterified fatty acids (NEFA) level as well as myocardial NEFA extraction. The metabolic behavior suggests the effectiveness of bunitrolol in the treatment of ischemic heart disease.

Angina Pectoris↗
PubMed1977

[Changes in myocardial metabolism during atrial pacing and catecholamine stimulation in normal subjects and patients with angina].

5 patients with angina had their threshold for angina evaluated by atrial pacing and by stimulation with catecholamine (dopamine). The authors then studied the metabolic changes induced by the two types of anginogenic load (AP and D-test) applied successively, and compared them with the post-ergometry ECG changes (lowering of the ST segment by at least 2 mm) and the findings on coronary arteriography (complete obstruction of at least 75% stenosis of a major branch vessel). The metabolic measurements were controlled against those of 5 normal subjects after standard ergometry. In the patients with angina, the AP test led to a constantly negative value for %. L. By contrast, the values of D(a-v)c and % O2 which were reduced in the normals, as indirect evidence of an increased coronary flow, remained practically static. During the dopamine infusion, although the % L was reduced, it remained essentially positive, while the D(a-v)c and % O2 were consistantly lowered.

Adult↗