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Biomedical subjects

F Contreras

Publications and source records attributed to F Contreras.

At least 55 records · Page 3Linked to original sources
PubMed1991

[Kaposi's sarcoma associated with chronic B lymphocytic leukemia. Coexistence of both diseases in skin lesions].

Kaposi's sarcoma is a rare malignancy. Its association with second primary cancers, especially of the lymphoreticular system, has been relatively frequently noted. We report a case of Kaposi's sarcoma (SK) in a 62 years-old women, affected by B-cell chronic lymphocytic leukemia (LLC B) for 22 month, that had received chemotherapy. Two skin lesions were seen on left lower limb. A biopsy revealed the coexistence of both diseases in the skin lesions. This finding is extremely rare. We review the possible etiopathogenic implications of this association and of the coexistence of both diseases in the same lesion.

Female↗
PubMed1991

Histiocytic cytophagic panniculitis: report of a case in a 12-year-old girl.

We report a 12-year-old girl with nodular skin lesions, fever, pancytopenia, coagulation defects and a fatal outcome within 4 months. Histopathology revealed proliferation of histiocytes with haemophagocytosis in skin, perivisceral fat and haemopoietic organs. The symptoms were most consistent with cytophagic histiocytic panniculitis.

Blood Coagulation Disorders↗
PubMed1991

Neonatal lupus erythematosus with multisystem organ involvement preceding cutaneous lesions.

Here we report a case of neonatal lupus erythematosus syndrome presenting with multisystem organ involvement, including anemia, thrombocytopenia, purpura, bloody diarrhea, enzymatic liver abnormalities, splenomegaly and pneumonitis. These findings preceded the cutaneous rash that was the clue for the diagnosis. The patient's mother had an undiagnosed subacute cutaneous lupus erythematosus. The various forms of onset of neonatal lupus erythematosus syndrome are emphasized.

Adult↗
PubMed1990

Screening and surgical intervention results from cataract-free-zone projects in Campinas, Brazil and Chimbote, Peru.

Two cataract-free-zone projects, one in Brazil and the other in Peru, were designed to provide surgery to all those who need and want it within a defined geographic area. In-home visual acuity screening was accepted by three-fourths of the enumerated population aged 50 years or more. Those with reduced bilateral visual acuity were referred to a community health post for ophthalmic examination. Among those diagnosed as bilaterally blind (less than or equal to 20/200), comprising 5% of the screened population, two-thirds were thought to be blind from cataract. Because of other ocular pathology and general health conditions, surgery was not indicated for 30-50%. Two-thirds of those recommended for out-patient surgery accepted. Motivational efforts to convince the refusers were uniformly unsuccessful. The average age of those accepting and those refusing surgery was in the mid-seventies. Those already aphakic were 7-8 years younger. Post-operative acuity was greater than or equal to 20/50 for only one-half of those operated. A significant number of cases had previously undetected macular degeneration and other causes of decreased vision. These projects have given increased attention to cataract blindness and the need for further operational research to develop effective methods for its control using outpatient surgery.

Aged↗
PubMed1990

Multiple self-healing indeterminate cell lesions of the skin in an adult.

We report a case of multiple cutaneous indeterminate cell proliferative lesions in an adult without any other organ involvement. All lesions regressed spontaneously over 5 years without recurrence over a 4-year period of follow-up. The electron-microscopic and immunohistochemical features of the cellular infiltrate were those of the indeterminate cells. This case supports the hypothesis that indeterminate cell proliferative disorder is a wide spectrum of conditions with variegated clinicopathologic presentation and with different biological behavior.

Cell Line↗
PubMed1990

The natural history of vasculitis. What the histology tells us about pathogenesis.

While histopathologic analysis may offer some clues as to the pathogenesis of vasculitis, observations must be interpreted with caution, as there is considerable overlap in the histologic pattern. In most cases, a predominantly neutrophilic vasculitis affecting small dermal venules suggests a relatively acute, immune complex-mediated reaction. Less commonly, this histologic pattern may be seen in non-immunologically mediated processes, such as in the presence of bacterial toxins or malignant hypertension, or in more chronic disease states, such as granuloma faciale or erythema elevatum diutinum. A predominantly lymphocytic vasculitis may represent several pathogenetic mechanisms. In lesions more than 24 to 48 hours old, a lymphocytic vasculitis may represent a resolving phase of an immune complex-mediated neutrophilic vasculitis. Alternatively, this histologic pattern may be seen de novo in conditions with a presumed cell-mediated immunologic pathogenesis. Lymphocytic vasculitis may also be seen in rickettsial infections such as Rocky Mountain spotted fever. The pathogenesis of granulomatous vasculitis remains poorly understood and is thought to be induced by a combination of circulating immune complexes and a cell-mediated immune response.

Granuloma↗
PubMed1989

[Multicentric reticulohistiocytosis: histochemical, histoenzymatic and immunocytochemical study].

Report of a case of multicentric reticulohistiocytosis with clinical, histopathologic, histochemical and immunohistochemical study. Neutral mucins and lipids were demonstrated in the cytoplasm of dermal histiocytes. The monocyte-histiocytic nature of the cells was shown by means of acid phosphatase, ATP-ase, muramidase and alpha-1-antitrypsin. Due to the immunohistochemical results, the relationship with Langerhans cells was rejected. No secretory activity of immunoglobulins was shown and the proliferation qualified as benign. The cells among the histiocytic population were typified as mature T lymphocytes.

Adult↗
PubMed1988

Histological reactions of human endometrium to the IUD.

A comparative study was made of four intrauterine contraceptive devices: the Nova-T, MLCu250 Short, MLCu375 and the Gyne T. An endometrial biopsy was performed on the 25th day of the menstrual cycle. The tissue obtained was analyzed to determine endometrial morphology patterns. After two years of IUD use, no inflammatory changes were demonstrated with MLCu375. Histological responses of the endometrium to the IUD depend on the amount of copper in the IUD.

Adult↗
PubMed1988

Malignant rhabdoid tumor of the tongue. A case report with immunohistochemical and ultrastructural findings.

An extrarenal malignant rhabdoid tumor of the tongue in a 10-day-old boy is described. The tumor produced severe respiratory distress and had an aggressive clinical course. The patient died 17 days after the initial diagnosis. The tumor was mostly composed of poorly differentiated, round, polygonal or elongated cells. Ultrastructural examination showed intracytoplasmic filamentous inclusions in many of the cells. The cytoplasm was diffusely positive to anti-vimentin antibodies with focal, scarce positivity to anti-keratin antibodies. To the best of our knowledge, this is the first reported case of malignant rhabdoid tumor of the oral cavity.

Cell Nucleus↗
PubMed1987

Mycobacterium chelonei peritonitis due to hematogenous dissemination in a continuous ambulatory peritoneal dialysis patient.

Renal failure patients have been found to have a special susceptibility to Mycobacterium infections. In patients undergoing peritoneal dialysis, Mycobacterium chelonei peritonitis, due to penetration through the peritoneal catheter lumen, has been described. In our report, we described a case of disseminated M chelonei infection that began in a Thomas hemodialysis prosthesis and finally resulted in peritonitis of hematogenous origin. The diagnostic and therapeutic peculiarities are discussed.

Adult↗