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Biomedical subjects

F Confalonieri

Publications and source records attributed to F Confalonieri.

At least 55 records · Page 3Linked to original sources
PubMed1988

Primary hypothyroidism due to leukemic infiltration of the thyroid gland.

We describe a patient with acute B-lymphocyte lymphoblastic leukemia who developed laboratory changes (not detectable free thyroxine, TSH 66 microIU/ml) suggesting severe primary hypothyroidism. Histological examination at autopsy showed massive leukemic infiltration of the thyroid gland: the progressive reduction of thyroid hormone levels with concomitant increase in TSH levels observed over a three-month period from the onset of the hemopathy suggests a cause-effect relationship between leukemic infiltration of the thyroid gland and hypothyroidism.

Acute Disease↗
PubMed1986

[Changes in several immunological parameters and the presence of anti-HTLV III antibodies in drug addicts].

The immunological picture in a group of heroin addicts and in a methadone treated group was evaluated. Ninety-six per cent shows modifications of the lymphocyte pattern, independently of the type of opium derivative administered. The OKT4/OKT8 ratio considered one of the hallmarks of acquired immunodeficiency, turns out to be reduced in 64.6% of the cases. In these latter the most outstanding defect is made up by the T-helper drop (83.8% of cases), limited to 23.5% in the group with normal OKT4/OKT8 ratio. The most significant variant between the two groups is represented by the positivity of anti-HTLV III test, which switches from 47 to 74.1% in the patients with reduced ratio. Immunoglobulins turn out to be increased in 81.2% of the cases, independently of the opium derivative administered and without significant differences in relation to the OKT4/OKT8 ratio. Therefore two immunological patterns seem to coexist in the population studied, which very likely represents two evolutive moments of the same disorder with an earlier phase of hyperimmune condition from a persistent antigenic stimulation which characterizes the situation at risk. In a later phase, the impact of HTLV III infection causes the deletion of the lymphocyte helper subpopulation which elicits the immunodepressive situation.

Adolescent↗
PubMed1984

[Richter's syndrome. Presentation of a rare variant with regression of chronic lymphatic leukemia and review of the literature].

The incidence of a lymphoreticular system malignancy in patients with chronic lymphocytic leukemia (CLL), Richter's syndrome (RS), is 3.3 to 10.6%. In 89 cases in the literature, the second neoplasm was either reticulum cell sarcoma or large cell diffuse histiocytic lymphoma (DHL), and there were 61 cases of Hodgkin's disease (HD). In a few cases the lymphoma was simultaneously diagnosed, for other cases an association with preexisting CLL was reported. Appearance of lymphoma was associated with leukemia regression for only 4 patients with DHL and 3 with HD. We report one case of B-lymphocyte CLL with macroglobulinemia, treated with melphalan and prednisone, in which DHL developed and the hematologic and histologic signs of CLL and of paraproteinemia remissed. Such patients might constitute a subgroup or a variant of RS. Since the non-Hodgkin malignant lymphomas (NHML) are considered to be monoclonal neoplastic expansion of the B-cell or T-cell lymphocytes, and since in some cases it has been proved that the proliferative cell clone was the same as that of the initial lymphoproliferative disease, RS could be a dedifferentiation or a transformation of CLL, resulting in an aggressive clinical course. The inclusion in this syndrome of CLL cases associated with HD is still controversial. Many of these cases could be giant cell pleomorphic lymphomas, while, on the contrary, in typical cases this association might be merely fortuitous.

Blood Transfusion↗
PubMed1983

[Difference in the behavior of T-lymphocyte populations in heroin and methadone addicts].

An assessment of T-lymphocyte populations was performed in two groups of drug addicts by the technique of monoclonal antibodies. Group I was composed of 11 asymptomatic heroin addicts, group II being in heroin withdrawal program from at least six months. Homosexual subjects, partners of patients with AIDS and patients with liver abnormalities or with recent infectious diseases were excluded from the present study. In all the examined subjects the antibody pattern to Toxoplasma gondii, Epstein-Barr virus, Cytomegalovirus was either negative or slightly positive as after old infections. All subjects were HBsAg negative and HBsAb positive. Group I patients showed a significant inversion of OKT4/OKT8 ratio (p less than 0.01), due to a reduction in T helper lymphocytes (p less than 0.05) and an increase in T suppressors (p less than 0.05). Both groups showed a not significantly different proliferative response to Phytohemagglutinin (PHA) and Concanavalin A (Con A), although 8 out of 11 patients of group I exhibited a reduced proliferative response to PHA. Group I patients also showed a reduced proliferative response to Pokeweed mitogen (PWM). These results might suggest an involvement of B-lymphocytes in immunological changes of heroin addicts. In group II patient all the examined variables, OKT4/OKT8 ratio, absolute number as well as percentage of T-lymphocytes subpopulations and proliferative responses to the employed mitogens, resulted in the normal range. These data seem to exclude that methadone, in contrast with heroin, may induce a cell-mediated immunodepression.(ABSTRACT TRUNCATED AT 250 WORDS)

Acquired Immunodeficiency Syndrome↗
PubMed1980

[Surgical treatment of perforated duodenal ulcer. Review of 36 cases].

Results obtained in the surgical management of 36 cases of perforated duodenal ulcer treated between January 1976 and November 1979 are presented. A choice was made between three methods (suturing, excision plus pyloroplasty and truncular vagotomy, and Péan-Billroth resection and reconstruction) in the light of the duration of the disease, the extent of the duodenal alterations, and the concomitance of serious disorders. No account was taken of age, the time elapsed between perforation and treatment, or the extent of peritoneal reaction.

Duodenal Ulcer↗
PubMed1978

[A case of oral localization of Crohn's disease. Review of the literature].

A case of Crohn's disease with specific tonsillar, pharyngeal and laryngeal lesions is presented. The unusualness of this site was clear from the literature. Stress is laid on the ubiquity of lesions indicative of the systemic nature of the disease. The intestinal lesions contain a viral agent that can be transmitted to animals.

Adolescent↗