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Biomedical subjects

F Colombo

Publications and source records attributed to F Colombo.

At least 235 records · Page 13Linked to original sources
PubMedDate not supplied

[Changes in hormonal and biochemical parameters in gastric adenocarcinoma].

In 51 patients with gastric adenocarcinoma the fasting blood concentrations of hCG, beta hCG, alpha subunits, ADH, calcitonin, enteroglucagon, gastrin, GH, melatonin, somatostatin, estradiol, CEA and pepsinogen I in the peripheral vein were estimated by radioimmunoassay at the time of diagnosis and, in those who underwent surgery, 7 days after the operation, to determine the incidence of the modifications of the above mentioned substances' blood levels and the existence of possible markers. In presence of increases of the examined parameters greater than 50%, considering M +/- 2 SD of 10 control subjects as normal range, the tumours were examined immunohistochemically. In patients with gastric adenocarcinoma, in comparison with normal subjects, we found significant higher blood levels of hCG alpha subunits, gastrin and CEA and lower of melatonin, pepsinogen I and GH. The immunohistological results demonstrated CEA in both examined cases, alpha subunits in 2 of 6 (respectively in dysplasic areas and in surrounding non neoplastic mucosa) and enteroglucagon in 1 of 3 (dysplasic areas). Our results indicate that none of the parameters we examined, because of their non-specificity or of the low incidence of their modifications, can be considered a marker of gastric adenocarcinoma.

Adenocarcinoma↗
PubMedDate not supplied

New diagnostic and screening possibilities in the stenobliterative lesions of the deep visceral vessels.

The evolution and continuous improvement of the ultrasonic diagnostic devices allows an hemodynamic and morphological exploration of the deep abdominal vessels that until now seemed to be precluded to non invasive diagnostic techniques. For example, the angiodynography today advantageously substitutes classical urographic investigation during the initial screening of the hypertensive patients suspected of stenotic lesions of the renal arteries. In fact the ecocolordopplersonography allows not only a morphological evaluation of the parenchyma and of the renal vascular tree, but also supplies a quantitative measurement of the blood flow through the renal artery. Still more important are the possibilities offered by these devices in the study of the acute or chronic intestinal ischemia, in which until now a sure diagnosis was only possible using invasive techniques. Performing a study of the mesenteric vascularization urgently, sometimes is possible a decisive demonstration of an ischemic pathology where the clinical abdominal picture provides only uncertain diagnostic elements.

Abdomen↗
PubMedDate not supplied

[Late hemorrhage as an unusual complication of placenta increta. A clinical case].

A 26 year old patient is urgently submitted to cesarean section for acute fetal pain. After 23 days, hysterectomy has been performed because of haemorrhagic shock. The pathology revealed a placenta increta. The lack of risk factors and the long, asymptomatic period between delivery and haemorrhage make this case noteworthy.

Adult↗
PubMedDate not supplied

[Comparative evaluation of the efficacy of naproxen sodium and ibuprofen in the treatment of primary dysmenorrhea].

Efficacy of Naproxen sodium and Ibuprofen have been compared in the treatment of primary dysmenorrhoea on 67 women aged between 13 and 20 casually divided into two groups. No statistically significant difference has been noticed in the remission of symptomatology between the two groups at therapeutic dosage, although Naproxen sodium has a longer plasmatic half-life than Ibuprofen.

Adolescent↗
PubMedDate not supplied

[Blood pressure changes induced by physical exercise and tyramine infusion in hypertensive and normotensive subjects].

The aim of our investigation was to assess blood pressure (BP) and heart rate (HR) variations in 20 essential hypertensive male inpatients (WHO class I and II) and in 20 normotensive healthy volunteers submitted to three provocation tests: isometric handgrip (IHG), bicycle ergometric exercise (BEE) and tyramine infusion (TI) given as i.v. boluses with saline in a single-blind manner. According to our data, IHG induced a comparable rise of systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate in both hypertensive and normotensive subjects. BEE, compared with IHG, caused a more significant (p less than 0.01) rise in SBP and heart rate in both groups. By contrast, DBP during BEE increased significantly in hypertensive (p less than 0.01), but decreased slightly in normotensive subjects (p = n.s.). TI caused a dose dependent SBP rise in both groups studied, while DBP and HR were unaffected. BP elevation was, however, more marked in hypertensive subjects. Confirming this finding, significantly lower tyramine doses were required to produce the same SBP increase in hypertensive patients than in the normotensive volunteers. In short, an SBP rise during TI, and a DBP rise during BEE may be the markers of enhanced cardiovascular reactivity on the part of hypertensive subjects. Our study suggests that BP reactivity to stress may be different according to the laboratory stress employed and also that BEE and TI are more useful than IHG for the assessment of enhanced cardiovascular response to stress in hypertensive subjects.

Adult↗
PubMedDate not supplied

Effect of naloxone on TRH-induced PRL and TSH response in normal man.

The effect of naloxone on PRL and TSH response to TRH was studied in 8 normal men. PRL response to TRH was unaffected by the administration of naloxone. TSH response to TRH was significantly decreased by naloxone, considering the maximum absolute increment (p less than 0.01) and the areas under curves (p less than 0.05). In conclusion, the PRL response to TRH may be unaffected by endogenous opioids or naloxone and we were unable to reveal a possible opioid effect in our experimental conditions. TSH response to TRH seems to be affected by endogenous opioids, possibly due to an indirect or direct action on TRH and/or on the pituitary.

Adult↗
PubMedDate not supplied

Linear accelerator radiosurgery. A clinical experience.

A clinical experience obtained by the employ of a radiosurgical technique utilizing a standard linear accelerator and a multiple non coplanar arc irradiation modality is presented. The series consists of 155 patients treated from November 1982 until March 1988. These patients harbored intracranial lesions deemed not suitable to open craniotomy procedures.

Adolescent↗
PubMedDate not supplied

[Determination of prolactin secretion in idiopathic galactorrhea].

We have studied 15 women with idiopathic galactorrhoea and normal serum PRL basal values, regularly menstruating, with normal x-ray of the sella turcica and mammography. The patients were not suffering from other endocrine diseases nor taking medications known to cause galactorrhoea. These subjects and 5 normal women were submitted to an evaluation of the serum PRL circadian rhythm, to TRH test for PRL and TSH, metoclopramide test for PRL, and basal determination of TT3 and TT4. The results did not show any significant difference between the two groups and did not reveal any abnormality of PRL secretion in the patients. These data, resulting from a homogeneous series of patients, support the hypothesis of an increased sensitivity of breast receptors to PRL, or of the secretion of heterogeneous forms of PRL, biologically active on mammary tissue, but not detected by current RIA methods for PRL.

Adult↗
PubMedDate not supplied

Stereotactic biopsy of low-grade giant-cell astrocytoma.

Stereotactic biopsy was used to sample a hypodense lesion of the left temporo-occipital lobes in a 32-year-old female with a history of grand mal seizures. Although the intraoperative cytologic examination showed a picture suggestive of malignancy, including giant cells and atypical mitotic figures, the clinical and radiologic history militated against a malignant nature for the lesion, which was thus classified as a low-grade giant-cell astrocytoma. This case emphasizes both the utility of intraoperative cytologic examination of stereotactic biopsy specimens and the need to consider the cytologic and histologic evidence in light of the clinical and radiologic findings.

Adult↗
PubMedDate not supplied

Stereotactic radiosurgery of intracranial tumors in childhood.

The Authors have developed an original stereotactic technique by which the radiation dose erogated by a 4 MV linear accelerator is focused into the target volume with a steep dose gradient at its borders. The technique has been employed in a series of 30 patients affected by deep seated brain tumors and AVMs. The paper deals with the preliminary results obtained in a series of 10 patients in pediatric age.

Adolescent↗